DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BMP1 and Corin

DIOPT Version :9

Sequence 1:NP_006120.1 Gene:BMP1 / 649 HGNCID:1067 Length:986 Species:Homo sapiens
Sequence 2:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster


Alignment Length:453 Identity:86/453 - (18%)
Similarity:139/453 - (30%) Gaps:161/453 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   398 GSKLPEPIVSTDSRLWVEFRSSSNWVG-----KGFFAVYEAICGG-------DVKKDY---GHIQ 447
            |..|||.:   :.:|:.:|.||.:.||     :...|.....|.|       .:.::|   ||:.
  Fly   871 GLSLPEYL---NCKLFKDFPSSEDCVG
LDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLD 932

Human   448 SPNYPDDYR-----PSKV------CIWRIQVSEGFHVGLTFQSFE------IERHDSCAYDYLEV 495
            ..:..|:.:     |.::      ||....:.:|. :...:...|      .||:.......|||
  Fly   933 CMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGI-IDCPYGQDERNCLRLSERNGDVGTGVLEV 996

Human   496 -RDGHSE-------------SSTLIGRYCGYEKPDDIK--------------STSSRLWLKFVSD 532
             |.|..:             |.:.:....||...:...              :.|:.:|..:...
  Fly   997 YRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKR 1061

Human   533 GSINKAGFAVNFFKEVD-----------ECSRPNRGGCEQRCLNTLGSYKCSCDPG---YELA-- 581
            .|.....|| |..|..|           ||.|..||. .:.....:|..:.|  ||   :..|  
  Fly  1062 KSTLMQEFA-NCKKTEDYPMADLTCS
NYECGRVKRGR-HKPSRRIIGGTQAS--PGNWPFLAAIL 1122

Human   582 --PDKRRCEAACGGFLTKLNGSITS------------PGWPKE----------YPPNKNCIWQLV 622
              |:|   ...|.|.|......:|:            ..|..:          |...|..:..::
  Fly  1123 GGPEK---IFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVI 1184

Human   623 APTQYRISLQFDFFETEGNDVCKYDFV-----------------EVRSGLTADSKLH-GKFC--- 666
            ...||.:::..|      ||:..:...                 .||:       || |..|   
  Fly  1185 PHPQYNMAIAHD------NDIALFQLATRVAFHEHLLPVCLPPPSVRN-------LHPGTLCTVI 1236

Human   667 ----GSEKPEVITSQY--NNMRVEFKS--------DNTVSKKGFKAHFFSD--KDECSKDNGG 713
                ..:|....|.:|  |.::|...:        ||....:|.....|.|  ||.|..|:||
  Fly  1237 GWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGG 1299

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BMP1NP_006120.1 ZnMc_BMP1_TLD 121..320 CDD:239808
Astacin 128..321 CDD:279708
CUB 322..431 CDD:278839 11/37 (30%)
CUB 435..544 CDD:278839 26/163 (16%)
FXa_inhibition 555..587 CDD:291342 9/38 (24%)
CUB 591..700 CDD:278839 26/165 (16%)
FXa_inhibition 707..742 CDD:291342 4/7 (57%)
CUB 747..856 CDD:278839
CUB 860..973 CDD:278839
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 8/25 (32%)
LDLa 911..942 CDD:238060 5/30 (17%)
LDLa 945..979 CDD:238060 5/34 (15%)
SR 980..>1034 CDD:214555 10/53 (19%)
SRCR 992..1086 CDD:278931 16/94 (17%)
Tryp_SPc 1103..1343 CDD:214473 41/215 (19%)
Tryp_SPc 1104..1346 CDD:238113 41/214 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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