DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and CG15253

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_609758.1	Gene:	CG15253 / 34916	FlyBaseID:	FBgn0028948	Length:	253	Species:	Drosophila melanogaster

Alignment Length:	217	Identity:	79/217 - (36%)
Similarity:	107/217 - (49%)	Gaps:	13/217 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   114 GRSRS-RRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLE-RTDEDSYI 176
            |.||: .|..|.|    ||:.:|.:.|........|.....|::..|..:|:||.| .||:..|:
  Fly    44 GSSRNIWRNETYR----WPNRIIYYHINSYIDEEHRNHIVSAIQKIESISCLTFKEATTDQKYYV 104

Human   177 VFTYRPCGCCSYVGRRGG----GPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIV 237
            ..|....||.||:|....    ..|...||..|.:...:|||..|.:||:|:.:..|||.:|.||
  Fly   105 NVTSEEGGCFSYIGYLNRVQQLNLQNNEIGVGCFRLYTIVHEFLHALGFFHQQSAADRDDYVQIV 169

Human   238 RENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQR 302
            .|||..|.|:||.|...:.|...||.||:.|:|||....||:. ...||:...|  |.:..||||
  Fly   170 EENITEGMEFNFDKYTEETVNDFGEKYDYGSVMHYGPYAFSKN-GERTILALEE--GKEDVIGQR 231

Human   303 TRLSKGDIAQARKLYKCPACGE 324
            ..||:.||.:...:||||...|
  Fly   232 LELSETDIRKLNAIYKCPTVKE 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	72/203 (35%)
		Astacin	128..321	CDD:279708	71/197 (36%)
		CUB	322..431	CDD:278839	1/3 (33%)
		CUB	435..544	CDD:278839
		FXa_inhibition	555..587	CDD:291342
		CUB	591..700	CDD:278839
		FXa_inhibition	707..742	CDD:291342
		CUB	747..856	CDD:278839
		CUB	860..973	CDD:278839
CG15253	NP_609758.1	Astacin	55..250	CDD:279708	72/201 (36%)
CG15253	NP_609758.1	ZnMc_astacin_like	59..246	CDD:239807	66/189 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810