DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BMP1 and Semp1

DIOPT Version :9

Sequence 1:NP_006120.1 Gene:BMP1 / 649 HGNCID:1067 Length:986 Species:Homo sapiens
Sequence 2:NP_609756.1 Gene:Semp1 / 34914 FlyBaseID:FBgn0028944 Length:251 Species:Drosophila melanogaster


Alignment Length:201 Identity:68/201 - (33%)
Similarity:109/201 - (54%) Gaps:15/201 - (7%)


- Green bases have known domain annotations that are detailed below.


Human   130 WPDGVIPFVIGGN-FTGSQRAVFRQAMRHWEKHTCVTFLERTDED--SYIVFTYRPCGCCS-YVG 190
            ||:..:|::|..: |..|......:|:...|:::||.|...|:.|  ..:|.|.:..||.: ::|
  Fly    53 WPNRTVPYMIEDDAFADSHYREILRAISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTVHLG 117

Human   191 RRGGGPQAIS-----IGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFL 250
            .| ...|.::     :|:.|.:.|.::|||.||:||.|:|...:||::|||..:||.|....||:
  Fly   118 YR-NKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFV 181

Human   251 KMEPQEV-ESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQAR 314
            ..:.... ....|.||::|:|||....|||. ...||||..|  |.: .:|||..:|:.||.:..
  Fly   182 NNDNSTAWHDFDEGYDYESVMHYVPRAFSRN-GQPTIVPLRE--GAE-NMGQRFYMSEKDIRKLN 242

Human   315 KLYKCP 320
            |:|:||
  Fly   243 KMYRCP 248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BMP1NP_006120.1 ZnMc_BMP1_TLD 121..320 CDD:239808 66/199 (33%)
Astacin 128..321 CDD:279708 68/201 (34%)
CUB 322..431 CDD:278839
CUB 435..544 CDD:278839
FXa_inhibition 555..587 CDD:291342
CUB 591..700 CDD:278839
FXa_inhibition 707..742 CDD:291342
CUB 747..856 CDD:278839
CUB 860..973 CDD:278839
Semp1NP_609756.1 Astacin 53..249 CDD:279708 68/201 (34%)
ZnMc_astacin_like 55..245 CDD:239807 63/194 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3714
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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