DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and CG15255

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_001285958.1	Gene:	CG15255 / 34913	FlyBaseID:	FBgn0028950	Length:	261	Species:	Drosophila melanogaster

Alignment Length:	320	Identity:	93/320 - (29%)
Similarity:	141/320 - (44%)	Gaps:	79/320 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     9 LLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFL-GDIALDEEDLRAFQVQQAV 72
            |||.::|  ..|:||                |....||.:|..|: ||:.|.||..|..:
  Fly    10 LLLQVVL--NSGKPL----------------PAGVYDPEEAGGFVEGDMMLTEEQQRNLE----- 51

Human    73 DLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPF 137
                                                    :|..::|....:..:| ||..|:.:
  Fly    52 ----------------------------------------QGAPKARNGLINTEKR-WPGNVVVY 75

Human   138 VIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDED-SYIVFTYRPCGCCSYVGRRGGGPQAIS- 200
            .|..:|..:.:...:..:...|.|||:.|.|.|||| :|:..|.:..||.:.||.: |.||.::
  Fly    76 RISDDFDTAHKKAIQTGIDTLELHTCLRFREATDEDKAYLTVTAKSGGCYTAVGYQ-GAPQEMNL 139

Human   201 ----IGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLG 261
                :|:.|.:.|.::||..|.:||:|:.:...||..::::.|||.||:|:||.|.....|....
  Fly   140 EIYPLGEGCFRPGTILHEFMHALGFYHQQSSSIRDDFINVIYENIVPGKEFNFQKYADTVVTDFE 204

Human   262 ETYDFDSIMHYARNTFS-RGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCP 320
            ..||:||.:||....|| .|  .||||| .:.:.|   ||||..||..||.:...:||||
  Fly   205 VGYDYDSCLHYRPGAFSING--EDTIVP-LDSSAV---IGQRVGLSSKDIDKINIMYKCP 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	71/205 (35%)
		Astacin	128..321	CDD:279708	73/200 (37%)
		CUB	322..431	CDD:278839
		CUB	435..544	CDD:278839
		FXa_inhibition	555..587	CDD:291342
		CUB	591..700	CDD:278839
		FXa_inhibition	707..742	CDD:291342
		CUB	747..856	CDD:278839
		CUB	860..973	CDD:278839
CG15255	NP_001285958.1	Astacin	66..258	CDD:279708	71/199 (36%)
CG15255	NP_001285958.1	ZnMc_astacin_like	70..255	CDD:239807	66/191 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810