DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and Neto

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_001285211.1	Gene:	Neto / 32303	FlyBaseID:	FBgn0265416	Length:	822	Species:	Drosophila melanogaster

Alignment Length:	336	Identity:	98/336 - (29%)
Similarity:	148/336 - (44%)	Gaps:	63/336 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   437 GDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ-SFEIERHDSCAYDYLEVRDGHS 500
            ||..|:  .:.||.||:.|..:..|...|...:|..:.|.|: ||.||..:.|.:|:||:|||..
  Fly   145 GDPTKN--ELYSPEYPNLYPKNINCTRVITAPKGQIIRLDFRNSFNIEAKEGCKFDFLEIRDGQY 207

Human   501 ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLN 565
            ..|||||::||.:.|.:|.|....|||.|.||.:|...||:..:  |..:.||.
  Fly   208 GFSTLIGKFCGTDFPPEITSKERYLWLHFHSDETIEYTGFSAVY--EYLDRSRD----------- 259

Human   566 TLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEY--PPNKN-----CIWQLVA 623
                     .|..:|     .|....|||    .|.|.|...|.|.  ..|:|     |||::..
  Fly   260 ---------APSTDL-----NCTIDKGGF----EGFINSTDVPAEIWEQVNRNKIALDCIWRIQV 306

Human   624 PTQYRISLQF-DFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKS 687
            ...::|.|:| ||..::.|| |:.:|:::....|........|||| ..|.||::.|.:.:.|.:
  Fly   307 KENWKIFLKFLDFKLSKPND-CQTNFLDIFPEQTVMPLRVKNFCGS-AGESITAESNILHLRFYA 369

Human   688 DNTVSKKGFKAHFFSDKDE---CSKDNGGCQQ-DCVNTFGSYECQCRSGFVLHDNKHDCK----E 744
            |.|.....|...|.:.::.   |::|...|:. .|:    |.:.:|       :|..:||    |
  Fly   370 DQTAINSTFGILFTAFRERGAACTEDEYDCEDATCI----SKDLKC-------NNLDNCKFRWDE 423

Human   745 AGCDHKVTSTS 755
            .||..:....|
  Fly   424 EGCTSEAAGQS 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808
		Astacin	128..321	CDD:279708
		CUB	322..431	CDD:278839
		CUB	435..544	CDD:278839	43/107 (40%)
		FXa_inhibition	555..587	CDD:291342	2/31 (6%)
		CUB	591..700	CDD:278839	35/116 (30%)
		FXa_inhibition	707..742	CDD:291342	7/35 (20%)
		CUB	747..856	CDD:278839	2/9 (22%)
		CUB	860..973	CDD:278839
Neto	NP_001285211.1	CUB	151..252	CDD:238001	40/102 (39%)
		CUB	<298..384	CDD:238001	26/87 (30%)
		LDLa	392..426	CDD:238060	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910