Protein Alignment PCDH20 and pcdh20

DIOPT Version :10

• Sequence 1: NP_073754.2
• Gene: PCDH20 / 64881
• HGNCID: 14257
• Length: 951
• Species: Homo sapiens
• Sequence 2: NP_001093700.1
• Gene: pcdh20 / 100101710
• XenbaseID: XB-GENE-484153
• Length: 894
• Species: Xenopus tropicalis
• Alignment Length: 910
• Identity: 645/910 - (70%)
• Similarity: 759/910 - (83%)
• Gaps: 35/910 - (3%)

Human    45 HLFLFFLFV---GPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLP 106
            ||...:|..   |....|.|.||||||||:|.||||.||.|||:.:||:|
 Frog    17 HLLFLWLLAHVRGSLFSLASNSRATELLYTLQEGLPKGVHIGSIGDDLQL--------------- 66

Human   107 ERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSS 171
               ....:|||||||||:|||.:||.|:|.:|||.||::|:||||||..              |.
 Frog    67 ---DVFADPPLSFSLASKGLSEKYVNLNNSTGELCTSSEELDREALCPH--------------SL 114

Human   172 PSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVD 236
            .:..|:||||:::|||||||.:||||||.|||||||.|||.||.:.||||||||||:.|||||.|
 Frog   115 VAQECVLLLDIIILPQEYFRLIKVKIAIIDINDNAPHFPVPQIYISVPENAPVNTRIVIEHPAYD 179

Human   237 PDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLL 301
            ||.|.||||||||:||||:|||||||||:||||||||:||.|||||:.:|.:.|||||||||||:
 Frog   180 PDGGTNGVQTYRLVDYHGVFTLDVEENESGERTPYLIIMGPLDRETKAEYETTIIAEDGGSPPLV 244

Human   302 GSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQA 366
            |||||:|.|||:|||||.|..||||.|:|||:|:||.:..|.|:|:|||.||.|||::|::||||
 Frog   245 GSATLSILISDVNDNCPQFNASQINATLYGNSTIGTQVVTVHAMDRDLGPNALITYAFSERVPQA 309

Human   367 SKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYI 431
            .|:.|||||..|:|||..:|.||.::.||||||||||||||||||..:||.|:.|||||::||||
 Frog   310 VKEYFHLDELKGIIKLSKRIDGSTVQQHKLTILANGPGCIPAVITVFISINKITFRPPELIPRYI 374

Human   432 ANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTKPMD 496
            |||.:||:||||||||::|:|||||:||:.||:|||||:|:||||||.:||||||||||||..:|
 Frog   375 ANEENGVIYLKELEPVHSPLAFFTIKDPDEKYQVNCYLEGQGPFRLSAFKPYNNEYLLETTDALD 439

Human   497 YELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATD 561
            |||:|.|.:||||.:.:|..||:::|||:||:|||:|:|.:..:|:||||||.|||||.||||||
 Frog   440 YELKQSYNIAVVALSRDGHQVKKLLKVQILDENDNSPVFTESTVEITIEENNEPNAFLAKLYATD 504

Human   562 ADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVA 626
            |||.|.|||||||||||||||:||||||||:|||.||||||||||:||:|.|.|.|.|||||||.
 Frog   505 ADSNESGQVSYFLGPDAPSYFTLDSVTGILSVSTILDREEKEKYRFTVKARDAGFPSRESVATVH 569

Human   627 LTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGK 691
            :||||||||:||||:|||||||||||||:||||||||||||:|:|||:|||:.|.|||||||.||
 Frog   570 ITVLDKNDNNPRFISKDFSFFVPENFPGFGEIGVISVTDADSGQNGWIALSIGNGSDIFVIDNGK 634

Human   692 GMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLP 756
            |:|||||||||||||||||||||||||:|.|||||||||||||:|||||:|||||||||||||||
 Frog   635 GLLRAKVSLDREQQSSYTLWVEAVDGGDPTLSSTAKITILLLDVNDNPPMVLFPQSNMSYLLVLP 699

Human   757 STLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLL 821
            ||||||||||||||||||||||||||||||||||:||||||||.||||||||||:..|.||:|||
 Frog   700 STLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPKPESFRIDPITGNITLEEALMINDCGLYRLL 764

Human   822 VKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSC 886
            ||||||||||||.|||||||||||||:||||||:||:|||:||||||||||::||:.:::||.||
 Frog   765 VKVSDHGYPEPLFSTVMVNLFVNDTVTNESYIETLLKKEPDINIEEKEPQIAMEPSQKEMESDSC 829

Human   887 MPTLVALSVISLGSITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI 951
            .||||.||:|.|||:.|||.||:|||||||:...|.:||.||||||..|||.||.|::|::||||
 Frog   830 TPTLVTLSIICLGSVILVTLMGMYICLRKGKNDHRINENAEVQIPLNRKIDFHMLEKRPIEISNI 894

Human   952  951
             Frog   895  894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCDH20	NP_073754.2	Cadherin_2	70..>153	CDD:462413	40/82 (49%)
		Cadherin_repeat	218..316	CDD:206637	77/97 (79%)
		Cadherin_repeat	324..416	CDD:206637	57/91 (63%)
		Cadherin_repeat	438..531	CDD:206637	62/92 (67%)
		Cadherin_repeat	540..635	CDD:206637	77/94 (82%)
		Cadherin_repeat	644..738	CDD:206637	81/93 (87%)
		Cadherin_repeat	754..845	CDD:206637	82/90 (91%)
pcdh20	NP_001093700.1	Cadherin_2	45..127	CDD:462413	48/113 (42%)
		Cadherin_repeat	156..259	CDD:206637	79/102 (77%)
		Cadherin_repeat	267..359	CDD:206637	57/91 (63%)
		Cadherin_repeat	381..474	CDD:206637	62/92 (67%)
		Cadherin_repeat	484..578	CDD:206637	77/93 (83%)
		Cadherin_repeat	587..681	CDD:206637	81/93 (87%)
		Cadherin_repeat	697..788	CDD:206637	82/90 (91%)