Protein Alignment chico and IRS4

DIOPT Version :9

• Sequence 1: NP_001188772.1
• Gene: chico / 64880
• FlyBaseID: FBgn0024248
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: XP_011529363.1
• Gene: IRS4 / 8471
• HGNCID: 6128
• Length: 1300
• Species: Homo sapiens
• Alignment Length: 1269
• Identity: 263/1269 - (20%)
• Similarity: 435/1269 - (34%)
• Gaps: 418/1269 - (32%)

  Fly    13 GYLKKLKTMKKKFFVLYEETSTSAARLEYYDTEKKFLQRAE--------------------PKRV 57
            |||:|.|...:::|||..||:.:.||||||:..:||.....                    |:||
Human    83 GYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRV 147

  Fly    58 IYLKNCFNINRRLDTKHRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQRNIANSN----GT- 117
            |.|..||::::|.|.::|.:|.|.::|..|.:|.|||::...|   .|:|.|.|..|.    ||
Human   148 ITLYQCFSVSQRADARYRHLIALFTQDEYFAMVAENESEQESW---YLLLSRLILESKRRRCGTL 209

  Fly   118 ----------------AHSP-YDHVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTP 165
                            |..| |..||||:::.:|:..:..::|.:..|||.:.:.||.:..|
Human   210 GAQPDGEPAALAAAAAAEPPFYKDVWQVIVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTE--- 271

  Fly   166 NGEDRVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMS 230
                 |||:.:.|.:||||||:  :..|::|:||.:|:|.|:|||:.|:..:|.|||...|..|.
Human   272 -----VASVVVQLLSIRRCGHS--EQYFFLEVGRSTVIGPGELWMQVDDCVVAQNMHELFLEKMR 329

  Fly   231 A-------------KTESNTNLINVYQNRPDLSHEPMR-----KRS------------SSANE-- 263
            |             ......:|:.:...|..|...|:.     :||            ...:|
Human   330 ALCADEYRARCRSYSISIGAHLLTLLSARRHLGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEML 394

  Fly   264 -------ASKPINVNVIQNSQNSLEL-------RSCSSPHNYGFGRERCDSLPTR---------- 304
                   .|:|    |..:.:..|.|       |:.|.|.:  |.|....| |.|
Human   395 FTRRFVTPSEP----VAHSRRGRLHLPRGRRSRRAVSVPAS--FFRRLAPS-PARPRHPAEAPNN 452

  Fly   305 ------------NGTLSESSN----------------QTYFGSNHGLRSNTISGIRPHSTNKHSN 341
                        :|...|..|                ...:||.:|..|....|.....::.||:
Human   453 GARLSSEVSGSGSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSS 517

  Fly   342 SPTFTMPLRCSESEESSISVDESDDNGSFSHYRLNTRSSETAIPE-------------------- 386
            ...     :||...:.|.....|:..||..: :.:.....||...
Human   518 GGN-----QCSGEGQGSRGGQGSNGQGSGGN-QCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGP 576

  Fly   387 ----------------------------ENIDDFASAELFSKVTEQNVSDENYIPMNPVNP---- 419
                                        |..........|.|:|:   |.:..:|..|..|
Human   577 GDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQ---SKQQQMPPPPPPPPPPP 638

  Fly   420 --------------------TDAIHEKEKADMQRLEDASLHFNFPEHASE--KLAKDFDLDSDNQ 462
                                .|....||..:.:.::||.:    ||.|:.  ..|:.||.|.|:.
Human   639 PAGGTGGKGKSGGRFRLYFCVDRGATKECKEAKEVKDAEI----PEGAARGPHRARAFDEDEDDP 699

  Fly   463 C--CRPIRAYSIGNKVEHLKF--------NKRLGHLNDTGQNPN-------RVRAYSVGSKSKIP 510
            .  .||..|..:.:..:::..        .||  |.....::..       ||......|..|.|
Human   700 YVPMRPGVATPLVSSSDYMPMAPQNVSASKKR--HSRSPFEDSRGYMMMFPRVSPPPAPSPPKAP 762

  Fly   511 RCDLQRVVLVEDNKHEFTANRSQSSITKEGTSYG----SSANRQKKSTSAPLLSLKNQINSDRMS 571
            ..:.:     :|:|.    |.|:|.........|    :..|.|..|:|....|..:..|..|.|
Human   763 DTNKE-----DDSKD----NDSESDYMFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSS 818

  Fly   572 DLMEIDFSQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTAIT 636
            .|.:.|.|:...:...||:......:...|..||    |::|.                     .
Human   819 PLGQNDNSEYVPMLPGKFLGRGLDKEVSYNWDPK----DAASK---------------------P 858

  Fly   637 SEDGYLEMKPVGNGYTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKIS----TYNISAE 697
            |.:|... || |:|.:||           |.||::  ||......|    |::|    .|.|..:
Human   859 SGEGSFS-KP-GDGGSPS-----------KPSDHE--PPKNKAKRP----NRLSFITKGYKIKPK 904

  Fly   698 KWREQPSRSE-EKKSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLN----- 756
            .  ::|:..: |..|:|...:..|:.:.:|..:.| :..:..:..|..|...:..|:.:|
Human   905 P--QKPTHEQREADSSSDYVNMDFTKRESNTPAPS-TQGLPDSWGIIAEPRQSAFSNYVNVEFGV 966

  Fly   757 ------NHLAD---KIVENNNLDIGG------------------HEEKKLVHSISSEDYTQIKDK 794
                  |.|:|   .|...|.|.:..                  .||...:..|.:...|.....
Human   967 PFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVIFNSAMTPAMAL 1031

  Fly   795 SNDFTKFNEAGYKILQIK------SDSSLISSKLYQ-----KGIHKDNLERSQRLTES------- 841
            ::...:::....:|..:.      .|.||..|:..:     :.:.::..||.:..:.|
Human  1032 ADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQSFFAAA 1096

  Fly   842 ---VNTIPDN--------ATATAVSSSSLTKFNINSAKPAAAADSRSTGTDPSTPQNILQIKDLN 895
               |:..|.:        ::|.||:|::.....::....||:|.:.:.|...:...       ..
Human  1097 RAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASALAAAPGIGAAAAA-------AG 1154

  Fly   896 FPSRSSSRISQPELHYASLDLPH-----CSGQNPAKY-----LKRGSR------------ESPP- 937
            |.| :|:|..||..:.|..:...     ..|.||..:     |.||..            |.||
Human  1155 FDS-ASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGDNQAGGAAAAAAAPEPPPR 1218

  Fly   938 ---VSACPE------DGNTYAKIDFDQSDSSSSS 962
               |...||      |.:|:.::||.:.|:...|
Human  1219 SRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDS 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	40/118 (34%)
		PH	25..104	CDD:278594	32/98 (33%)
		PTB_IRS	122..235	CDD:269915	41/125 (33%)
IRS4	XP_011529363.1	PH_IRS	79..202	CDD:269959	41/121 (34%)
		PTB_IRS	231..334	CDD:269915	41/112 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152292
Domainoid	1	1.000	94	1.000	Domainoid score	I7478
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41286
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10614
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.890