DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chico and Irs3

DIOPT Version :9

Sequence 1:	NP_001188772.1	Gene:	chico / 64880	FlyBaseID:	FBgn0024248	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_114463.1	Gene:	Irs3 / 84021	RGDID:	69317	Length:	494	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	116/467 - (24%)
Similarity:	197/467 - (42%)	Gaps:	92/467 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LSGYLKKLKTMKKKFFVLYEETSTSAARLEYYDTEKKFL----QRAEPKRVIYLKNCFNINRRLD 71
            |.|:|:|.|:.:::||||    .....|||.|::|||||    :...|:|.:.|:....|::|.|
  Rat    35 LCGHLRKQKSQRRRFFVL----RADPPRLECYESEKKFLASGCRPPRPRRTVSLEGACTISKRAD 95

  Fly    72 TKHRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQRNIANSNGTA-------------HSPYD 123
            .:.|.:||:.:.|...|:...:|.:.:.|...||.::...|.:..||             .:|:.
  Rat    96 ARQRHLIVIYTSDSSLGVAAASEAEQQTWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQ 160

  Fly   124 HVWQVVIQKKGISEKVGI-TGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEIL---LTTIRRC 184
            .||.|.::.||:....|: :|:|..||.|.:|:.: ..|....:.:.|.....:|   |.::|||
  Rat   161 DVWPVTLRSKGLGRAPGLSSGSYRLCLGSGALSLL-RKPGSKGSRDSRATPPPVLRLSLLSVRRC 224

  Fly   185 GHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAM--------SAKTESNTNLIN 241
            |||  ...|::||||.:.:|.|:||::..:|.:|.::|.|:|:||        |.|.|:
  Rat   225 GHA--DSFFFLELGRSAPIGPGELWLQAPDAVVAQSIHETVLAAMKRLGSSAASGKAEA------ 281

  Fly   242 VYQNRPDLSHEPMRKRSSSANEASKPINVNVIQNSQNSLELRSCS----SPHNYGFGRERCDSLP 302
                  .|...|   :.:||..|..|..:..:     :|..::.|    :..:|....||..|.|
  Rat   282 ------PLGDSP---KGASAVPAPAPYEIPAL-----ALAAQARSPGERAKQDYVNPLERMGSAP 332

  Fly   303 TRNG--------TLSESSNQTYFGSN---------HGLRSNTISGIRPHSTNKHSNSPTFTMPL- 349
            :..|        .:...::..:.|..         .||...|...:.|....:...|..: ||:
  Rat   333 SYRGPDLGGDYIAMGMRNDYVHMGGKAAEYMWMAPPGLPPPTPPRVDPRKEPEDCESTEY-MPMN 396

  Fly   350 -------------RCSESEESSISVDESDDNGSFSHYRLNTRSSETAIPEENIDDFASAELFSKV 401
                         |..|...||......|..........:::.||.:.....|.|:.||.|.|..
  Rat   397 RFLPGPLYYEFKAREPEHGHSSAQCSIRDRWRPMVAQPRSSQGSELSGDYMYIPDYPSARLGSLD 461

  Fly   402 TEQNVSDENYIP 413
            :..|..|.:.:|
  Rat   462 SCLNYVDLDLVP 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	33/104 (32%)
		PH	25..104	CDD:278594	26/82 (32%)
		PTB_IRS	122..235	CDD:269915	40/124 (32%)
Irs3	NP_114463.1	PH_IRS	32..132	CDD:269959	33/100 (33%)
		PH	33..131	CDD:278594	33/99 (33%)
		PTB_IRS	159..273	CDD:269915	38/116 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345792
Domainoid	1	1.000	94	1.000	Domainoid score	I7284
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm45414
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10614
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.800