DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chico and si:ch211-284e13.4

DIOPT Version :9

Sequence 1:	NP_001188772.1	Gene:	chico / 64880	FlyBaseID:	FBgn0024248	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_021327314.1	Gene:	si:ch211-284e13.4 / 566919	ZFINID:	ZDB-GENE-060526-161	Length:	1181	Species:	Danio rerio

Alignment Length:	1152	Identity:	254/1152 - (22%)
Similarity:	410/1152 - (35%)	Gaps:	360/1152 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASISDDGMALSGYLKKLKTMKKKFFVLYEETSTSAARLEYYDTEKKFLQRAE-PKRVIYLKNCF 64
            |...|.:.:..||||:|.|:|.::||||...:....||||||:.||||..::. ||:.:.|.:||
Zfish     7 MEQQSYEDVRKSGYLRKQKSMHRRFFVLRAASEQGPARLEYYENEKKFRSKSPVPKKAVNLDSCF 71

  Fly    65 NINRRLDTKHRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQ-----RNIANSNGTAHSP--- 121
            |||:|.|:|::.:|||.:|...|.|..:.|....:|...:|.||     .:...|.|....|
Zfish    72 NINKRADSKNKHMIVLYTRGESFAIAADTEEVQNEWYQAMLDLQCKCKTPDECGSGGDCGLPSPG 136

  Fly   122 --YDHVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEILLTTIRRC 184
              :..||||.:..||:.:...:.|.|..|||.|::.||.:..:        ||::.:.|..:|||
Zfish   137 PAFKEVWQVKVWPKGLGQARNLIGIYRLCLTDKTVNFVKLNSD--------VAAVVLQLMNVRRC 193

  Fly   185 GHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTNLINVYQNRPDL 249
            ||:  :..|::|:||.::.|.|:.||:.:::.:|.|||.|:|.||.|.:|.
Zfish   194 GHS--ENFFFIEVGRSAMTGPGEFWMQVEDSVVAQNMHETLLEAMKALSEE-------------- 242

  Fly   250 SHEPMRKRSSS--------ANEASKPINVNVIQNSQN--------SLELRSCSSP--HN------ 290
                .|:||.|        ...||.||:|...::..|        |...|: .:|  ||
Zfish   243 ----FRQRSKSQTVGVSCGGGTASNPISVPSRRHHPNLPPSQVGFSRRART-ETPGVHNTNTSPT 302

  Fly   291 --YGFGRERCDSLPTR----NGTLSESSNQTYFGSNHGLRSNTISGIRPHSTNKHSNSPT---FT 346
              :||.|.|..|:..|    .|..:..|...   |.:|...:|...:||    |.:.:||   .|
Zfish   303 PRHGFSRSRTASIGARTEDGGGRATALSTSP---SLNGSSCSTTPTLRP----KPTRAPTPAKIT 360

  Fly   347 MPL---RCSESEESSISVDESDDNGS--------------FSHYRLNTRSSETAIPEE--NIDDF 392
            :.|   ..:.:...:.|:..|..:||              .::.|:..|.|.:..|.:  :.|::
Zfish   361 LSLARYTPNPAPSPAPSLSSSSGHGSECGLGGATFGAVPICTYARIPQRVSMSGSPSDYGSSDEY 425

  Fly   393 AS---------AELFSKVTEQNVSDENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEHAS 448
            .|         |.|.:.:.|...|   ||.|   ...:..|::                  .|..
Zfish   426 GSSPGEHSLLAAGLPAALVEGGAS---YILM---GHREGSHKR------------------VHGR 466

  Fly   449 EKLAKDFDLDSDNQCCRPIRAYSIGNKVEHLKFNKR--LGHLNDTGQNPNR-------VRAYSVG 504
            ..|.:    .|..:|           :||....:||  |...:..|..|.|       ...|:|.
Zfish   467 RVLRR----SSSREC-----------EVERRLLSKRASLPPTSTQGLVPRRREEEEEDEEEYAVM 516

  Fly   505 SKSKIPRCDLQRVVLVEDNKHEFTANRSQSSITKEGTSYGSSANRQKKSTSAPLLSLKNQINSDR 569
            |:|.              ::..||:.|.............:||::...:...|   ..:.|:|..
Zfish   517 SRSA--------------SRESFTSRRGSGGSATTSLVQENSADKGVSTKGGP---EDSSIDSGY 564

  Fly   570 MSDLMEIDFSQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTA 634
            ||.|..:                            .||   .:||:|..:....:..|
Zfish   565 MSMLPGV----------------------------TAP---PASLSLAVSGSDAVPKG------- 591

  Fly   635 ITSEDGYLEMK-------------PVGNGY---TPSSNCLP-------------MKVEKLKLSDY 670
               .|.|:.|.             |:..||   :|:|:|.|             ..:|....|||
Zfish   592 ---GDEYMAMTPNNSVSPPQHIRLPISEGYMMMSPNSSCSPDLHGMSGCIWGSRGSMESRAGSDY 653

  Fly   671 QTAPPLTATAA----PVH----DLNKISTYNISAEKWREQPSRSEEKKSNSPLNDNTFSSKPTNV 727
            ....|::|.:|    |.|    .|.....|:     :...|...:....::...||.........
Zfish   654 MNMSPISARSACSTPPSHPEQQPLQPKMVYS-----YFSLPRSYKHATLSARFEDNLERVCMGRG 713

  Fly   728 ESTSKSHDVHSA--------------NQIDCEKVCAQSSDKLNNHLADKIVENNNLDIGG----- 773
            |:..|:.  |||              .|:........||...:..|.|:.:   :|.:||
Zfish   714 EAAGKTG--HSAYDCGGDTPVGSGGGGQLSLSSSSFSSSSASSESLEDRSL---SLSVGGVGRAA 773

  Fly   774 -------------------HEEKKLVHSISSEDYTQI-KDKSN----DFTKFN---EAGYKILQI 811
                               |.::.....:..:.:.|. ||||:    |.:|.|   .....:|..
Zfish   774 RLSTGHRVRGAHPKITSQHHHQQSCGRGVPKQGHLQTRKDKSSSYFVDMSKANTLPRVRETLLPT 838

  Fly   812 KSDS-SLISSKLYQ--KGIHKDN----------------LERSQRLTESVNTIPDNATATAVSSS 857
            .|.| ....|.:||  :|.||..                ..|.|........:|.:.:|...:|.
Zfish   839 ASQSPGEYVSIVYQGERGGHKGRTAVESGNSRTQGHQRAFHRPQPCQGGSANLPRSFSAPLATSI 903

  Fly   858 SLTKFNINSAKPAAAADSRSTGTDPSTPQNILQIKDLNFPS-RSSSRISQPELHYASLDLPHCSG 921
            ||:...:|          ...|:.||:...:...|    |: :....||:..|....:|:
Zfish   904 SLSSEYVN----------MDLGSSPSSLTPLSSFK----PAPKVRDEISRVPLVEQEVDM----- 949

  Fly   922 QNPAKYLKRGSRESPPVSACPED-----GNTYAKIDFDQSDSSSSSS 963
                     |.|:|......|:|     ...|.::.|.....|:|.|
Zfish   950 ---------GLRKSKVTGLTPKDVAAAPFTDYTEMKFGLGGDSTSKS 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	43/110 (39%)
		PH	25..104	CDD:278594	33/79 (42%)
		PTB_IRS	122..235	CDD:269915	39/112 (35%)
si:ch211-284e13.4	XP_021327314.1	PH_IRS	13..115	CDD:269959	41/101 (41%)
si:ch211-284e13.4	XP_021327314.1	PTB_IRS	139..242	CDD:269915	39/112 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586782
Domainoid	1	1.000	94	1.000	Domainoid score	I7398
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm24799
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10614
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.890