Protein Alignment chico and irs2

DIOPT Version :9

• Sequence 1: NP_001188772.1
• Gene: chico / 64880
• FlyBaseID: FBgn0024248
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: XP_031755459.1
• Gene: irs2 / 394823
• XenbaseID: XB-GENE-6455904
• Length: 809
• Species: Xenopus tropicalis
• Alignment Length: 1049
• Identity: 222/1049 - (21%)
• Similarity: 370/1049 - (35%)
• Gaps: 371/1049 - (35%)

  Fly    13 GYLKKLKTMKKKFFVLYEETSTSAARLEYYDTEKKFLQRAE----PKRVIYLKNCFNINRRLDTK 73
            |||:|.|:|:|::|||....:...||||||:.|||| :.||    |:.|:.|:..|.:|:|.|.|
 Frog     8 GYLRKQKSMRKRYFVLRCPGTRGPARLEYYENEKKF-RVAEGSGGPRGVLNLEEAFGVNKRSDAK 71

  Fly    74 HRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQRNIANSNGTAHSP---------YDHVWQVV 129
            .|.::|:.:||||.|:..:.|.:..:|...:|.:|   |.:...:.||         :..||||.
 Frog    72 KRHLLVIYTRDGGLGVSADGEEEQDEWYQAILEVQ---AQARALSSSPDAPAWPGPAFREVWQVS 133

  Fly   130 IQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEILLTTIRRCGHASPQCIFY 194
            ::.:|:.:...::|.|..||..::|..:.:..|.        .|:.:.|..:|||||:..  .|:
 Frog   134 VRPRGLGQTRNLSGIYRLCLAERTLGLLRLRSEN--------PSVTLQLMNVRRCGHSDN--YFF 188

  Fly   195 VELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTNLINVYQNRPDLSHEPMRKRSS 259
            ||:||.:|.|.|:|||:.:::.:|.|||.|||.||.:.:|.                  .|.|:.
 Frog   189 VEVGRSAVTGPGELWMQVEDSVVAQNMHETILEAMKSLSEE------------------FRPRTK 235

  Fly   260 SANEASKPINVNVIQNSQNSLELRSCSSPHNYGFGRERCDSLPTRNGTLSESSNQTYFGSNHGLR 324
            |.:.:|.||:|...::..|.      ..|...|..|......|..|..:.
 Frog   236 SQSLSSTPISVPSRRHHPNP------PPPSQVGISRRSRAETPIENSPVP--------------- 279

  Fly   325 SNTISGIRPHSTNKHSNSPTFTMPLRCSESEESSISVDESDDNGSFSHYRLNTRSSETAIPEENI 389
                   :|||.:|..:          .:|.|     :|.::.|:    |:.|..|.......:.
 Frog   280 -------KPHSLSKDYS----------VQSPE-----EEEEEKGA----RVETNESSADYGSASS 318

  Fly   390 DDFASAELFSKVTEQNV--------SDENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEH 446
            |::.|:   ..|.|..|        .:.|||.|       |::.:....|   |..|.:.|.|..
 Frog   319 DEYGSS---PGVLEAPVFLPPSPGPRETNYISM-------ALYGRRSLVM---EPISTNANVPAE 370

  Fly   447 ASEKLAKDFDLDSDNQCCRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPR 511
            ...:|
 Frog   371 EGSRL------------------------------------------------------------ 375

  Fly   512 CDLQRVVLVEDNKHEFTANRSQSSITKEGTSYGSSANRQKKSTSA--PLLSLKNQINSDRMSDLM 574
                                   ::.:|..:|.....|:.:..:.  |:|.     .|:|..|.|
 Frog   376 -----------------------TLFQEEDNYAMMGQREPRQETGYMPMLP-----GSNRSQDYM 412

  Fly   575 EIDFSQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTAITSED 639
                                         |..|                    |.::..|.....
 Frog   413 -----------------------------PMTP--------------------TSISPPAPVEMA 428

  Fly   640 GYLEMKPVGNGYTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKISTYNISAEKWREQPS 704
            ||:.|.|:|       :|.| ::|:|      :.||....:|...|.:.....|:    |    |
 Frog   429 GYVMMSPLG-------SCSP-EIERL------SWPPSQEVSAGSSDSHASDYMNM----W----S 471

  Fly   705 RSEEKKSNSPLNDNTFSSK------PTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHLADK- 762
            .|....|..|..:...||.      |.:..|..:|:.:..  |......|:.|||.|....|.|
 Frog   472 LSRSASSTPPPQEAFLSSPGGPCRVPASYRSLPRSYKMEP--QPSARASCSSSSDSLEEVNAGKN 534

  Fly   763 -------IVENNNLDIGGH-----------------EEKKLV---------HSISSEDYTQIKDK 794
                   |...|...:.|:                 .:||..         .|:|.|:..... .
 Frog   535 RRPLSISIDSWNTGTLSGNYRRPPSPGEYVSIHFRAPQKKTSGKEAIDAPRESVSMEEQPSAM-P 598

  Fly   795 SNDFTKFNEAGYKILQ--IKSDSSLISSKLYQKGIHKDN-----------LER--SQRLTESVN- 843
            :.|:|:.:...::.||  :|::.        ::|.:.:|           ||:  |::.:.:|:
 Frog   599 NGDYTEMDFVPHRTLQPHVKTNE--------ERGTNGENAFKPVGKLLPALEKTSSEKDSWAVDK 655

  Fly   844 ----TIPDNATATAVSSSSLTKFNINSAKPAA------AADSRSTG------------TDPSTPQ 886
                |....||...:.|.......:.:.||:|      :..|..||            .||||.:
 Frog   656 ALWPTTLREATGIPIESDLGRPEKVLAPKPSAEEPELKSLVSAVTGCSLNMGQDPPMRLDPSTRK 720

  Fly   887 NILQIKDLNFPSR-SSSRIS--QPELHYASLDLPH--CSGQNPAKYLKRGSRESPPVSA--CPED 944
            .... :.:..|:. :.:|.:  :|.|:|..|||..  ..|..||..:.:|....|.:.:  .|.:
 Frog   721 RHCS-ESVRPPAPCNGTRAAALEPGLNYIDLDLSKDAAGGVPPAVLVGQGGAPPPKIGSLGAPPN 784

  Fly   945 GNTYAKIDF 953
            .||||.|||
 Frog   785 INTYASIDF 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	41/102 (40%)
		PH	25..104	CDD:278594	32/82 (39%)
		PTB_IRS	122..235	CDD:269915	38/112 (34%)
irs2	XP_031755459.1	PH_IRS	2..110	CDD:269959	42/105 (40%)
		PTB_IRS	126..229	CDD:269915	38/112 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7707
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm48488
Panther	1	1.100	-	-	O	PTHR10614
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4611
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.130