DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chico and irs2a

DIOPT Version :9

Sequence 1:	NP_001188772.1	Gene:	chico / 64880	FlyBaseID:	FBgn0024248	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_021322439.1	Gene:	irs2a / 393285	ZFINID:	ZDB-GENE-040426-975	Length:	1086	Species:	Danio rerio

Alignment Length:	1038	Identity:	250/1038 - (24%)
Similarity:	401/1038 - (38%)	Gaps:	305/1038 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SISDDGMALSGYLKKLKTMKKKFFVLYEETSTSAARLEYYDTEKKFLQRAEPKRVIYLKNCFNIN 67
            :|..:.:...|||||.|...:::|||.:.:....|||||::.|||:..::.|||||:|.:|.:||
Zfish    17 NIHSNNIRKHGYLKKQKHGHRRYFVLKDTSDGLPARLEYHENEKKWKNKSAPKRVIFLDSCLSIN 81

  Fly    68 RRLDTKHRFVIVLSSRDGGFGIVLENENDLRKW-------LDKLLVLQRNIANSNGT-------- 117
            :|.|.|||::|.|.::|..|.:..|||.:...|       |.|..|....::||..:
Zfish    82 KRADAKHRYLIALYTKDEYFAVAAENEQEQESWYGDLADLLSKGKVCDSTVSNSASSLVGFDEGN 146

  Fly   118 ------AHSPYDHVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEI 176
                  .::.|..||||.::.||:.:...|||.:..||||::::||.:..|        |||:.:
Zfish   147 YGMITPVNAAYKEVWQVNLKAKGLGQSRNITGVFRLCLTSRTISFVKLNSE--------VASVTL 203

  Fly   177 LLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTNLIN 241
            .|..||||||:  ...|::|:||.:..|.|:|||:.|::.:|.|:|.|||.||.|..|
Zfish   204 QLMNIRRCGHS--DSFFFIEVGRSASTGPGELWMQADDSVVAQNIHETILEAMKAMKE------- 259

  Fly   242 VYQNRPDLSHEPMRKRSSSANEASKPI------NVNVIQNSQNSLELRS------CSSPHNYGFG 294
                   ||.  .|.||.|.:..|.||      |:|.:..||..|..||      .:||.. .|.
Zfish   260 -------LSE--FRPRSKSQSSGSNPISVPTRRNLNNLPPSQTGLVRRSRTDSTAATSPVT-KFS 314

  Fly   295 RERCDSLPTRNGTL--------SESSNQTYFGSNHGLRSNTIS-GIR---PHSTNKHSNSPTFTM 347
            ..|..:.....||:        ||:.:....|.:|..||||:| |.|   |...| ||.|.:.||
Zfish   315 SCRIRTASEGEGTMIRPVSVSVSENGSPMTVGRHHMSRSNTVSVGCRTSEPSLLN-HSRSMSMTM 378

  Fly   348 ----PLRCSESEESSISVDESDDNGSFS---HYRLNTRSSETAIPEE----NIDDFASAELFSKV 401
                |...|....||||:     |||.|   |...:...|.:..|.:    ..:|::|:....:.
Zfish   379 YHSPPSVVSPLSLSSISM-----NGSISNKAHRPSSCSGSVSGSPNDFGFLTCEDYSSSPGDVRY 438

  Fly   402 TEQNVSD--ENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEHASEKLAKD-FDLDSDNQC 463
            ...|.||  .:.....|:..|..:|.....|...        ||.::   |.::| .|:::..:
Zfish   439 NLANRSDTPSSLSSTPPLRETSELHSYMVMDRPS--------NFSQN---KTSRDMLDVETYRK- 491

  Fly   464 CRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVEDNKHEFT 528
                |.||:                    ..|.:..|:|..|.:.:....|.|..    |.|.
Zfish   492 ----RTYSL--------------------TTPRQQMAHSQLSSASLDEYMLMRAA----NSHS-- 526

  Fly   529 ANRSQSSITKEGTSYGSSANRQKKSTSAPLLSLKNQINSDRMSDLMEIDFSQATNLEKQKFI--- 590
                           |.|.|......|.|             .|..:|:.....|:....::
Zfish   527 ---------------GRSTNSASPKLSYP-------------EDYGDIEIGSNCNVGDDGYMPMT 563

  Fly   591 --------KNN----------EIPKYIENVFPKA-PRTDSSSLTLHATSQKDI--------FNGT 628
                    ||:          ..||.|.|  |:: |::..|..|.::.|...:        ::|:
Zfish   564 PGMAPQSAKNDHYMPMSPMSVSAPKQIIN--PRSHPQSPGSGCTANSPSSGSLEDSGYMKMWSGS 626

  Fly   629 KLNNTAITSEDG------YLEMKPVGNGYTPSSNCLPMKVEKLKLSDYQTAP-----PLTATAAP 682
            |.   ::.|.||      |:.|.||....:|                  |.|     |...|..|
Zfish   627 KF---SLESSDGKAANGEYVNMSPVDTSISP------------------TPPEYFMGPCEPTQRP 670

  Fly   683 VHDLNKISTYNISAEKWREQPSRSEEKKSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKV 747
                  ..|.:|...| ::.|.|.::       |...|.| |.|...|.:::.|.|...:....|
Zfish   671 ------SPTQSIRFNK-QQVPKRVDD-------NQYVFMS-PQNQNQTEEANSVSSLPPLYRPDV 720

  Fly   748 CAQSSDKLN--NHLA-------DKIVENN------------NLDIGG---HEEKKLVHSISSEDY 788
            .||.| |:|  |.|:       .::.|:.            |:|...   :..:.:|...:....
Zfish   721 MAQRS-KVNRPNRLSLDALRMLPRMTEHPLPCEPKSPGEYINIDFAAATQYSSQSMVTVENQASL 784

  Fly   789 TQIKDKS--NDFTKFNEAGYKILQIKSDSSLISSKLYQKGIHKDNLERSQRLTESVNTIPDNATA 851
            :.::..|  :|:...|::.:            ||||.:.....|.      |.|.....||:.|.
Zfish   785 SSLRQGSPLSDYMNLNQSSH------------SSKLCEMSSPLDG------LPELAECPPDDGTC 831

  Fly   852 -----------TAVSSSSLTKFNINSAKPAAAADSRSTGTDPSTPQNILQIKDLNFPSRSSSR 903
                       :.....:.|:.:.||   .:..:.:|....|::     :::.||..::..|:
Zfish   832 FLNEQRNLPCPSVSGKGNYTEMSFNS---GSLENQKSASVSPTS-----RVQRLNLGNQGVSK 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	42/111 (38%)
		PH	25..104	CDD:278594	34/85 (40%)
		PTB_IRS	122..235	CDD:269915	46/112 (41%)
irs2a	XP_021322439.1	PH_IRS	24..126	CDD:269959	41/101 (41%)
irs2a	XP_021322439.1	PTB_IRS	157..260	CDD:269915	47/126 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586778
Domainoid	1	1.000	94	1.000	Domainoid score	I7398
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm24799
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	O	PTHR10614
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4611
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.730