DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chico and Irs2

DIOPT Version :9

Sequence 1:	NP_001188772.1	Gene:	chico / 64880	FlyBaseID:	FBgn0024248	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_001074681.1	Gene:	Irs2 / 384783	MGIID:	109334	Length:	1321	Species:	Mus musculus

Alignment Length:	1177	Identity:	267/1177 - (22%)
Similarity:	421/1177 - (35%)	Gaps:	385/1177 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASISDDGMALS-------------GYLKKLKTMKKKFFVLY------EETSTSAA------RLEY 41
            ||...||..|:             |||:|.|...|:||||.      :|.|.:..      ||||
Mouse    11 ASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEASAAGGSPPQPPRLEY 75

  Fly    42 YDTEKKFLQRA-EPKRVIYLKNCFNINRRLDTKHRFVIVLSSRDGGFGIVLENENDLRKW---LD 102
            |::|||:..:| .|||||.|..|.|||:|.|.||:::|.|.::|..|.:..|||.:...|   |.
Mouse    76 YESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALT 140

  Fly   103 KLLVLQRNIANSNGT-------------------------------AHSPYDHVWQVVIQKKGIS 136
            .|:...|:....:||                               |.:.|..||||.::.||:.
Mouse   141 DLVSEGRSGEGGSGTTGGSCSASLPGVLGGSAGAAGCDDNYGLVTPATAVYREVWQVNLKPKGLG 205

  Fly   137 EKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEILLTTIRRCGHASPQCIFYVELGRQS 201
            :...:||.|..||:::::.||.:..|:        .|:.:.|..||||||:  ...|::|:||.:
Mouse   206 QSKNLTGVYRLCLSARTIGFVKLNCEQ--------PSVTLQLMNIRRCGHS--DSFFFIEVGRSA 260

  Fly   202 VLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTNLINVYQNRPDLSHEPMRKRSSSANEASK 266
            |.|.|:|||:.|::.:|.|:|.|||.||.|..|       :::.|      |..|..||.:.|:.
Mouse   261 VTGPGELWMQADDSVVAQNIHETILEAMKALKE-------LFEFR------PRSKSQSSGSSATH 312

  Fly   267 PINVNVIQNSQNSLELRSCSSPHNYGF-GRERCDSLPT----------RNGTLSESSNQTYFGSN 320
            ||:|...:...:.:.|    .|...|. .|.|.|||..          |..|.||.......|:.
Mouse   313 PISVPGARRHHHLVNL----PPSQTGLVRRSRTDSLAATPPAAKCTSCRVRTASEGDGGAAGGAG 373

  Fly   321 HG---------------------LRSNTIS---GIRPHSTN--------KHSNSPTFTMPLRCS- 352
            ..                     .||:|:|   |.||....        :||.|  .:||:..|
Mouse   374 TAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGGALQHSRS--MSMPVAHSP 436

  Fly   353 --ESEESSISVDESDDNGSF-----SHYRL-------------NTRSSETAIPEE----NIDDFA 393
              .:...|:|......:||:     ||..|             :..:|.:..|.:    ::|::.
Mouse   437 PAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQGQRPSSGSASASGSPSDPGFMSLDEYG 501

  Fly   394 SAELFSKVTEQNVSDENYIPMNPVNPTDAIHEKEKADMQRLEDASLH-FNFPEHASEKLAKDFDL 457
            |                       :|.|            |...|.| .|.||..:|
Mouse   502 S-----------------------SPGD------------LRAFSSHRSNTPESIAE-------- 523

  Fly   458 DSDNQCCRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVED 522
                  ..|.|..|.|....::..::.|.|..    .|.| |....|::      ||.|
Mouse   524 ------TPPARDGSGGELYGYMSMDRPLSHCG----RPYR-RVSGDGAQ------DLDR------ 565

  Fly   523 NKHEFTANRSQSSITKEGTSYGSSANRQKKSTSAPLLSLKNQINSDRMSDLMEIDFSQATNLEKQ 587
                        .:.|...|..:.| ||::.......||...       .||...||.::.....
Mouse   566 ------------GLRKRTYSLTTPA-RQRQVPQPSSASLDEY-------TLMRATFSGSSGRLCP 610

  Fly   588 KFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGT-KLNNTAITSEDGYLEMKP---VG 648
            .|..::  ||...|.:|:              ...||..|: |.:::.:.::|||:.|.|   :.
Mouse   611 SFPASS--PKVAYNPYPE--------------DYGDIEIGSHKSSSSNLGADDGYMPMTPGAALR 659

  Fly   649 NG------------YTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKISTYNISAEKWR- 700
            :|            .:|:|...|.::.:.:|:   .|.|.:..|.|........|:.::...::
Mouse   660 SGGPNSCKSDDYMPMSPTSVSAPKQILQPRLA---AALPPSGAAVPAPPSGVGRTFPVNGGGYKA 721

  Fly   701 EQPSRSEEKKS-------NSPL-----------NDNTFSSKPTNVESTSKSHDVHSANQIDCEKV 747
            ..|:.|..:.|       .|.|           |.:..:..|:...:.....|..:|.:...|.:
Mouse   722 SSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALRGGSEGL 786

  Fly   748 ------------------CAQSSDK----LNNHLADKIVENNNLDI-------------GGHEEK 777
                              |:.|.|.    |.:....:|:|...|:.             |.|.:.
Mouse   787 KGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGTFGAAGGSHTQP 851

  Fly   778 KLVHSI--SSEDYTQIKDKSNDF----------TKFNEAGYKILQIKSDSSL-ISSKLYQKGIHK 829
            .  ||.  ||...:.|..:...|          |:.:..|.:.|....:..| ...|...:.|:.
Mouse   852 H--HSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYPLPTEPKSPGEYINI 914

  Fly   830 DNLERSQRLTESVNTIPDNATATAVSSSSLTKFNINSAKPAAAADSRSTGTDPSTPQNILQIKDL 894
            |..|...||:.....:    .|:|.|||||    ::::.||::..|.:.||.
Mouse   915 DFGEAGTRLSPPAPPL----LASAASSSSL----LSASSPASSLGSGTPGTS------------- 958

  Fly   895 NFPSRSSSRISQPELHYASLDLPHCSGQNPAKYLKRGSRESPPVSA-----CPEDGNTYAKIDFD 954
                 |.||...|...|.:||.  .|.::|    |..:|....|.:     .||..:.|..:...
Mouse   959 -----SDSRQRSPLSDYMNLDF--SSPKSP----KPSTRSGDTVGSMDGLLSPEASSPYPPLPPR 1012

  Fly   955 QSDSSSS 961
            .|.|.||
Mouse  1013 PSTSPSS 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	49/133 (37%)
		PH	25..104	CDD:278594	38/94 (40%)
		PTB_IRS	122..235	CDD:269915	43/112 (38%)
Irs2	NP_001074681.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		5/20 (25%)
		PH_IRS	31..143	CDD:269959	44/111 (40%)
		PH	31..143	CDD:278594	44/111 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..73		2/21 (10%)
		PTB_IRS	191..294	CDD:269915	44/119 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..536		58/291 (20%)
		YXXM motif 1	536..539		0/2 (0%)
		YXXM motif 2	594..597		0/9 (0%)
		YXXM motif 3	649..652		1/2 (50%)
		YXXM motif 4	671..674		0/2 (0%)
		YXXM motif 5	734..737		0/2 (0%)
		YXXM motif 6	814..817		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..871		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	888..1091		40/164 (24%)
		YXXM motif 7	1061..1064
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1110..1198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1251..1275
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842359
Domainoid	1	1.000	94	1.000	Domainoid score	I7442
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm43342
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	O	PTHR10614
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4611
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.820