DRSC/TRiP Functional Genomics Resources

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Protein Alignment chico and IRS1

DIOPT Version :9

Sequence 1:NP_001188772.1 Gene:chico / 64880 FlyBaseID:FBgn0024248 Length:968 Species:Drosophila melanogaster
Sequence 2:NP_005535.1 Gene:IRS1 / 3667 HGNCID:6125 Length:1242 Species:Homo sapiens


Alignment Length:1082 Identity:246/1082 - (22%)
Similarity:401/1082 - (37%) Gaps:330/1082 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 GYLKKLKTMKKKFFVLYEETSTSA-ARLEYYDTEKKFLQRAE-PKRVIYLKNCFNINRRLDTKHR 75
            |||:|.|:|.|:||||...:.... ||||||:.|||:..::. |||.|.|::|||||:|.|:|::
Human    17 GYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNK 81

  Fly    76 FVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQR-------------------NIANSNGTAHSP 121
            .::.|.:||..|.|..::|.:...|...||.|..                   :.:.|:|...:.
Human    82 HLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAG 146

  Fly   122 YD-------------HVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVAS 173
            .|             .||||:::.||:.:...:.|.|..|||||:::||.:..|        .|:
Human   147 EDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSE--------AAA 203

  Fly   174 IEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTN 238
            :.:.|..||||||:  :..|::|:||.:|.|.|:.||:.|::.:|.|||.|||.||.|.::    
Human   204 VVLQLMNIRRCGHS--ENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSD---- 262

  Fly   239 LINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQN-------SQNSLELRS------CSSPHN 290
                 :.||       |.:|.|::..|.||:|.:.::       ||..|..||      .:||.:
Human   263 -----EFRP-------RSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPAS 315

  Fly   291 Y-----GFGRERCDSLPTRNGTLSE-----------SSNQTYFGSNHGLRSNTISGIRPHSTNKH 339
            .     |..|.|..|  ...||:|.           |:|:|:...:.|       ..|.|....|
Human   316 MVGGKPGSFRVRASS--DGEGTMSRPASVDGSPVSPSTNRTHAHRHRG-------SARLHPPLNH 371

  Fly   340 SNSPTFTMPL-RCSESEESSISVDES--DDNGSFSHYRLNTRSSETAIPEENIDDFASAELFSKV 401
            |.|  ..||. |||.|..|.:|:..|  ..:||.|......|||.:.....:...|.|::.:.. 
Human   372 SRS--IPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGS- 433

  Fly   402 TEQNVSDENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEHASEKLAKDFDLDSDNQCCRP 466
                            :|.|.     ::..:.:...||....|....|:|:        |..|  
Human   434 ----------------SPCDF-----RSSFRSVTPDSLGHTPPARGEEELS--------NYIC-- 467

  Fly   467 IRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVEDNKHEFTANR 531
                              :|     |:.|:                     .|...|.|...:..
Human   468 ------------------MG-----GKGPS---------------------TLTAPNGHYILSRG 488

  Fly   532 SQSSITKEGTSYGSSA--------------NRQKKST----SAPLLSLKNQINSDRMSDLMEIDF 578
            ........||..|:|.              ||.:|.|    ::|.::.:...:...::.:.|  :
Human   489 GNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEE--Y 551

  Fly   579 SQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTAITSEDGYLE 643
            ::..............:|.:..:.|..........|.:|...::.  ...:.:::.:.::|||:.
Human   552 TEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRG--GHHRPDSSTLHTDDGYMP 614

  Fly   644 MK----PVGNGYTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKISTYNISAEKWREQPS 704
            |.    ||.:|...|.:.:||..:              :.:||...:|.|          |..|.
Human   615 MSPGVAPVPSGRKGSGDYMPMSPK--------------SVSAPQQIINPI----------RRHPQ 655

  Fly   705 RSEEK----KSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHLADKIVE 765
            |.:..    .|.|..........|::  |:|.|:.|.|....                  .|:..
Human   656 RVDPNGYMMMSPSGGCSPDIGGGPSS--SSSSSNAVPSGTSY------------------GKLWT 700

  Fly   766 NNNLDIGGHEEKKLVHSISSEDYT--QIKDKSNDFTKFNEAGYKILQIKSDSSLISSKLY--QKG 826
            |.   :|||....|.|.....:.:  ::...:.|:...:..|      .|::|..|...|  :..
Human   701 NG---VGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVG------DSNTSSPSDCYYGPEDP 756

  Fly   827 IHKD-----NLERSQRLTESVNTIPDNA----------------TATAVSSSSLTKFNINSAKPA 870
            .||.     :|.||.:.|:......:.|                .|||..|||.|          
Human   757 QHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSST---------- 811

  Fly   871 AAADSRSTG-----TDPSTPQNILQIKDLNFP------SRSSSRISQPELHYASLDLPHCSGQNP 924
             ::||...|     .:||.|....|:...:.|      ::::||:::|    ..|.|    |...
Human   812 -SSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARP----TRLSL----GDPK 867

  Fly   925 AKYLKRGSRES--------PPVSACPEDGNTYAKIDF--DQS 956
            |..|.|...:.        ||.   |:....|..|:|  |||
Human   868 ASTLPRAREQQQQQQPLLHPPE---PKSPGEYVNIEFGSDQS 906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chicoNP_001188772.1 PH_IRS 7..112 CDD:269959 43/119 (36%)
PH 25..104 CDD:278594 33/80 (41%)
PTB_IRS 122..235 CDD:269915 45/125 (36%)
IRS1NP_005535.1 Mediates interaction with PHIP. /evidence=ECO:0000250 3..137 43/119 (36%)
PH_IRS 11..118 CDD:269959 43/100 (43%)
PTB_IRS 160..263 CDD:269915 44/121 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..430 49/194 (25%)
YXXM motif 1 465..468 1/22 (5%)
YXXM motif 2 551..554 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 592..616 3/25 (12%)
YXXM motif 3 612..615 1/2 (50%)
YXXM motif 4 632..635 0/2 (0%)
YXXM motif 5 662..665 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..693 7/26 (27%)
YXXM motif 6 732..735 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 771..900 30/150 (20%)
GRB2-binding. /evidence=ECO:0000250 896..898 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..937
YXXM motif 7 941..944
YXXM motif 8 989..992
YXXM motif 9 1012..1015
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1057..1146
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1190..1242
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152293
Domainoid 1 1.000 94 1.000 Domainoid score I7478
eggNOG 1 0.900 - - E1_28N3R
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7969
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001178
OrthoInspector 1 1.000 - - otm41286
orthoMCL 1 0.900 - - OOG6_105771
Panther 1 1.100 - - O PTHR10614
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4611
SonicParanoid 1 1.000 - - X1499
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.770

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