DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chico and Irs1

DIOPT Version :9

Sequence 1:	NP_001188772.1	Gene:	chico / 64880	FlyBaseID:	FBgn0024248	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_034700.2	Gene:	Irs1 / 16367	MGIID:	99454	Length:	1231	Species:	Mus musculus

Alignment Length:	1088	Identity:	254/1088 - (23%)
Similarity:	416/1088 - (38%)	Gaps:	295/1088 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASISD-DGMA---LSGYLKKLKTMKKKFFVLYEETSTSA-ARLEYYDTEKKFLQRAE-PKRVIY 59
            |||..| ||.:   ..|||:|.|:|.|:||||...:.... ||||||:.|||:..::. |||.|.
Mouse     1 MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIP 65

  Fly    60 LKNCFNINRRLDTKHRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQR--------------- 109
            |::|||||:|.|:|::.::.|.:||..|.|..::|.:...|...||.|..
Mouse    66 LESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGG 130

  Fly   110 NIANSNGTAHS----PYD--------HVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPE 162
            :.:.|:|...:    .||        .||||:::.||:.:...:.|.|..|||||:::||.:..|
Mouse   131 SCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSE 195

  Fly   163 KTPNGEDRVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILS 227
                    .|::.:.|..||||||:  :..|::|:||.:|.|.|:.||:.|::.:|.|||.|||.
Mouse   196 --------AAAVVLQLMNIRRCGHS--ENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILE 250

  Fly   228 AMSAKTESNTNLINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQN-------SQNSLELRS- 284
            ||.|.::         :.||       |.:|.|::..|.||:|.:.::       ||..|..||
Mouse   251 AMRAMSD---------EFRP-------RSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSR 299

  Fly   285 -----CSSPHNY-----GFGRERCDSLPTRNGTLSE-----------SSNQTYFGSNHGLRSNTI 328
                 .:||.:.     |..|.|..|  ...||:|.           |:|:|:...:.|
Mouse   300 TESITATSPASMVGGKPGSFRVRASS--DGEGTMSRPASVDGSPVSPSTNRTHAHRHRG------ 356

  Fly   329 SGIRPHSTNKHSNSPTFTMP-LRCSESEESSISVDES--DDNGSFSHYRLNTRSSETAIPEENID 390
             ..|.|....||.|  ..|| .|||.|..|.:|:..|  ..:||.|......|||.:.....:..
Mouse   357 -SSRLHPPLNHSRS--IPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDG 418

  Fly   391 DFASAELFSKVTEQNVSDENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEHASEKLAKDF 455
            .|.|::.:..                 :|.|.     ::..:.:...||....|....|:|:
Mouse   419 GFISSDEYGS-----------------SPCDF-----RSSFRSVTPDSLGHTPPARGEEELS--- 458

  Fly   456 DLDSDNQCCRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNR-VRAYSVGSKSKIP------RCD 513
                 |..|       :|.|...........::...|.|.:| :...::|:...:|      ..|
Mouse   459 -----NYIC-------MGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAAD 511

  Fly   514 LQRVVLVEDNKHEFTANRSQSSITKEGTSYGSSANRQKKSTSAPLLSLKNQINSDRMSDLMEIDF 578
            |.              ||.:......|||  .:.:.||..:.:.:.|:      :..:::|...:
Mouse   512 LD--------------NRFRKRTHSAGTS--PTISHQKTPSQSSVASI------EEYTEMMPAAY 554

  Fly   579 SQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTAITSEDGYLE 643
            .....       ....:|.|..:.|..........|.:|...::...:....:|  :.::|||:.
Mouse   555 PPGGG-------SGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTSN--LHTDDGYMP 610

  Fly   644 MKPVGNGYTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKISTYNISAEKWREQPSRSEE 708
            |.|         ...|:...:....||....| .:.:||...:|.|          |..|.|.:.
Mouse   611 MSP---------GVAPVPSNRKGNGDYMPMSP-KSVSAPQQIINPI----------RRHPQRVDP 655

  Fly   709 K--KSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHLADKIVENNNLDI 771
            .  ...||              |.|.|.|:...:........|.|.........:        .:
Mouse   656 NGYMMMSP--------------SGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTN--------GV 698

  Fly   772 GGHEEKKLVHS---ISSEDYTQIKDKSNDFTKFNEAGYKILQIKSDSSLIS-SKLY---QKGIHK 829
            |||....|.|:   :.|.. .::...:.|:...:..|        ||:..| |:.|   :...||
Mouse   699 GGHHTHALPHAKPPVESGG-GKLLPCTGDYMNMSPVG--------DSNTSSPSECYYGPEDPQHK 754

  Fly   830 D-----NLERSQRLTESVNTIPDNA----------------TATAVSSSSLTKFNINSAKPAAAA 873
            .     :|.||.:.|:......:.|                ||||..|||.|           ::
Mouse   755 PVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSST-----------SS 808

  Fly   874 DSRSTGTDPSTPQ--------NILQ---IKDLNFPSRSSSRISQPELHYASLDLPHCSGQNPAKY 927
            ||...|...:.|:        ::||   .:.::..::::||:::|.  ..||..|..|.....:.
Mouse   809 DSLGGGYCGARPESSLTHPHHHVLQPHLPRKVDTAAQTNSRLARPT--RLSLGDPKASTLPRVRE 871

  Fly   928 LKRGSRES--PPVSACPEDGNTYAKIDFDQSD--------SSSSSSNI 965
            .::..:.|  ||.   |:....|..|:|....        :|.||.::
Mouse   872 QQQQQQSSLHPPE---PKSPGEYVNIEFGSGQPGYLAGPATSRSSPSV 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	45/124 (36%)
		PH	25..104	CDD:278594	33/80 (41%)
		PTB_IRS	122..235	CDD:269915	46/120 (38%)
Irs1	NP_034700.2	Mediates interaction with PHIP. /evidence=ECO:0000250	3..133		47/129 (36%)
		PH_IRS	11..118	CDD:269959	43/106 (41%)
		PH	17..110	CDD:278594	40/92 (43%)
		PTB_IRS	155..258	CDD:269915	44/121 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..425		49/194 (25%)
		YXXM motif 1	460..463		1/9 (11%)
		YXXM motif 2	546..549		0/2 (0%)
		YXXM motif 3	608..611		1/2 (50%)
		YXXM motif 4	628..631		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..720		15/91 (16%)
		YXXM motif 5	658..661		0/2 (0%)
		YXXM motif 6	727..730		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..985		33/167 (20%)
		GRB2-binding. /evidence=ECO:0000250	891..893		1/1 (100%)
		YXXM motif 7	935..938
		YXXM motif 8	983..986
		YXXM motif 9	1006..1009
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1176..1231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842362
Domainoid	1	1.000	94	1.000	Domainoid score	I7442
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm43342
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	O	PTHR10614
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4611
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820