Protein Alignment chico and irs2

DIOPT Version :10

• Sequence 1: NP_723540.1
• Gene: chico / 64880
• FlyBaseID: FBgn0024248
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: XP_002933054.3
• Gene: irs2 / 100498409
• XenbaseID: XB-GENE-6455904
• Length: 1007
• Species: Xenopus tropicalis
• Alignment Length: 323
• Identity: 57/323 - (17%)
• Similarity: 109/323 - (33%)
• Gaps: 106/323 - (32%)

  Fly   131 DCWKRVNEAELA-----RKVRDMRESRTAPSVTQNLDRKVSGADKKVVLTSLQ-SFPRGMECI-- 187
            :||:..| .:.|     |.:::......|....:||.|             || :|.|..|.|
 Frog    87 NCWEPEN-TDYAIYLCKRTMQNKARLELADYEAENLAR-------------LQRAFARKWEFIFM 137

  Fly   188 ---DPLKLGIIDNKTLRLITESSE-------------------SLSKAEKVDNALR-EKLVY--- 226
               ..:|:....:||.|.|.:|.|                   .:.|..::.|..: :|.||
 Frog   138 QAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVT 202

  Fly   227 -TSDHFDPKLFISRIHQETSAADLESGALALKSDLKGRNLQRKQLVKDNF---DCFVSCKTTIDD 287
             .|....|...:|:..::|:..|:......|.:.:....|:..::.:...   :.:|.....|..
 Frog   203 EESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITP 267

  Fly   288 IESKLKRIEDDPDGSGTTHLFNCMKSVTSRANRAFEPLFERQAQAEKIRSVQGMLQRFRTLFNLP 352
            .|.....|.||      ..|::...|              ::...::::         |..|:..
 Frog   268 AEPSNPWISDD------VALWDIEMS--------------KEPSQQRVK---------RWGFSFD 303

  Fly   353 SIIRSSISKGE---------------YDLAVREYKKAKSIALPSHVNLLKRVLEEVEKVMQEF 400
            .|::..:.:.:               :.|||::.||..          |:.|.:.||::.|||
 Frog   304 EILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQP----------LQDVAKRVEEIWQEF 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_723540.1	PH_IRS	7..112	CDD:269959
		PTB_IRS	122..235	CDD:269915	29/138 (21%)
irs2	XP_002933054.3	PH_IRS	29..134	CDD:269959	13/60 (22%)
		PTB_IRS	179..282	CDD:269915	18/108 (17%)