DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-A2 and ADA2

DIOPT Version :9

Sequence 1:	NP_525020.2	Gene:	Adgf-A2 / 64879	FlyBaseID:	FBgn0043025	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001269154.1	Gene:	ADA2 / 51816	HGNCID:	1839	Length:	511	Species:	Homo sapiens

Alignment Length:	521	Identity:	167/521 - (32%)
Similarity:	281/521 - (53%)	Gaps:	43/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LCVMVLVLICSAPLGENMSNLTSEERHARLRQIYIEKERRQRLGSRMGLSPLEEEANDRLMAIR- 117
            ||.::|.:..|. .|   |.|:.:|..|.|    :.||:..|||.|:.|:..||.||:|||.::
Human    12 LCFLLLAVAMSF-FG---SALSIDETRAHL----LLKEKMMRLGGRLVLNTKEELANERLMTLKI 68

  Fly   118 -QVDEEFYNLWRNYHSQPPPF----LKHLNIIDTNLYAALKSMPKGGLLHVHDSGMLRMEILI-D 176
             ::.|....|     ..||..    .||| |..:.::..|:.||||..||:||.|::.|:.|: :
Human    69 AEMKEAMRTL-----IFPPSMHFFQAKHL-IERSQVFNILRMMPKGAALHLHDIGIVTMDWLVRN 127

  Fly   177 LIYRDNLWVCVNLEQDFEDFRFSRYFPHIPPAEDYQCN-WMLMSNF-FQLESRLEFENRLRKTLT 239
            :.||.:..:|.. .:....|||:    |..|....:|: |:|:.:: .::::..||::.|.:..|
Human   128 VTYRPHCHICFT-PRGIMQFRFA----HPTPRPSEKCSKWILLEDYRKRVQNVTEFDDSLLRNFT 187

  Fly   240 V---RPEGYKSSSELARHLRRHQRI---IHGLITFRPIWSEFIFTMLSDFYADGVHYVELRSSLP 298
            :   .||...::..:.  ..:.:.|   |.|||.:.|::.:::|..:.:||.|.|.|:|:|:.|.
Human   188 LVTQHPEVIYTNQNVV--WSKFETIFFTISGLIHYAPVFRDYVFRSMQEFYEDNVLYMEIRARLL 250

  Fly   299 NMYDLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYAPSRNLNDSRMDEYLENARLLKLHF 363
            .:|:|.|.:.....:.:....|:..|..:..:|||||:||:..|:.:.:.:.|.:..|..|::.|
Human   251 PVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKDVAVIAESIRMAMGLRIKF 315

  Fly   364 PNFFAGFDLNTFGDECNLPLLENVTQLLRI----GKNIDFYFHAGESRCPDSSRPDANLLEALLL 424
            |...|||||  .|.|.....|.:..:.|.|    |..:.::|||||:....:| .|.|:|:||:|
Human   316 PTVVAGFDL--VGHEDTGHSLHDYKEALMIPAKDGVKLPYFFHAGETDWQGTS-IDRNILDALML 377

  Fly   425 QSKRIGNAVNLPFHPEIMKVMKRLSIAVEICPLSNHYLQYFNDFRQHPAAYLIAAGFPIVIGSDY 489
            .:.|||:...|..||.:.....:..|.:|:||:||..|:..:|.|.||.|.|:|.|.|:||.||.
Human   378 NTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVATLMATGHPMVISSDD 442

  Fly   490 PCFWNSAPLTDDFYVAFVGVISGWGDLRLLKQFALNSFLFSSLSETEKNMAVSKWQCSWNRWVRN 554
            |..:.:..|:.|||..|:|:.....|||.|||.|:||..:|:|.|:|||..:..|:..|::::.:
Human   443 PAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTLLESEKNTFMEIWKKRWDKFIAD 507

  Fly   555 L 555
            :
Human   508 V 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A2	NP_525020.2	A_deaminase_N	52..152	CDD:285627	32/103 (31%)
		adm_rel	83..556	CDD:273620	158/492 (32%)
		ADGF	135..548	CDD:238646	139/429 (32%)
ADA2	NP_001269154.1	A_deaminase_N	12..102	CDD:285627	32/103 (31%)
		adm_rel	30..509	CDD:273620	160/499 (32%)
		Dimerization	30..100		25/79 (32%)
		ADGF	82..501	CDD:238646	139/429 (32%)
		PRB domain	127..185		14/62 (23%)
		Substrate binding	204..211		0/6 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159067
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.820