Protein Alignment Adgf-A2 and AMPD3

DIOPT Version :10

• Sequence 1: NP_525020.2
• Gene: Adgf-A2 / 64879
• FlyBaseID: FBgn0043025
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_000471.1
• Gene: AMPD3 / 272
• HGNCID: 470
• Length: 776
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 109/541 - (20%)
• Similarity: 187/541 - (34%)
• Gaps: 151/541 - (27%)

  Fly    58 VLVLICSAPLGENMSNLTSEERHARLRQIYIEKERRQRLGSRMGLSPLEEEANDRLMAIRQVDEE 122
            :|.||...|        |....|.||..:..:....:.|........|:...:.....:|:||..
Human   270 ILALITDGP--------TKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTH 326

  Fly   123 FY--------NLWRNYHSQPPPFLKHLNIIDTNLYAALKSMPKGGLLHVHDSGMLRMEILIDLIY 179
            .:        :|.|        |:||....:.:...|.|...|..|..|.|.  |.|: ..||..
Human   327 IHAAACMNQKHLLR--------FIKHTYQTEPDRTVAEKRGRKITLRQVFDG--LHMD-PYDLTV 380

  Fly   180 RDNLWVCVNLEQDFEDF-RFSRYFPHIPPAEDYQCNWMLMSNFFQLESRL--EFENRLRKTLTVR 241
             |:|.|... .|.|..| :|:..:..:..:|       |...:.:.|:.|  |:..|:.|
Human   381 -DSLDVHAG-RQTFHRFDKFNSKYNPVGASE-------LRDLYLKTENYLGGEYFARMVK----- 431

  Fly   242 PEGYKSSSELARHLRRHQ------RI-IHGLITFRPIWSEFIFTMLS-DFYADGVHYVELRSSLP 298
                    |:||.|...:      |: |:|.....  |....:..:. ..|:..:.::   ..:|
Human   432 --------EVARELEESKYQYSEPRLSIYGRSPEE--WPNLAYWFIQHKVYSPNMRWI---IQVP 483

  Fly   299 NMYDLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYAPSRNLNDSRMDEYLENARLLKLH- 362
            .:||       |..:.:.|.:...:.:|.|..      ::..:.|..|.|           :||
Human   484 RIYD-------IFRSKKLLPNFGKMLENIFLP------LFKATINPQDHR-----------ELHL 524

  Fly   363 FPNFFAGFDL---------NTFGDE-----------------------CNLPLLENVTQLLRIGK 395
            |..:..|||.         :.|.|:                       .|:.:|.|    ||..:
Human   525 FLKYVTGFDSVDDESKHSDHMFSDKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNN----LRRER 585

  Fly   396 NID-FYF--HAGESRCPDSSRPDANLLEALLLQSKRIGNAVNLPFHPEIMKVMKRLSIAVEICPL 457
            .:. |.|  |.||:       .....|.:..|.:..|.:.:.|...|.:..:.....|.:.:.||
Human   586 GLSTFLFRPHCGEA-------GSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPL 643

  Fly   458 SNHYLQYFNDFRQHPAAYLIAAGFPIVIGSDYPC--FWNSAPLTDDFYVAFVGVISGWGDLRL-- 518
            ||:.|  |.::.::|....:..|..:.:.:|.|.  .:....|.:::.:|    ...|   :|
Human   644 SNNSL--FLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIA----AQVW---KLST 699

  Fly   519 --LKQFALNSFLFSSLSETEK 537
              |.:.|.||.|.|.||..||
Human   700 CDLCEIARNSVLQSGLSHQEK 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A2	NP_525020.2	A_deaminase_N	59..152	CDD:462481	18/100 (18%)
		ADGF	135..548	CDD:238646	94/456 (21%)
AMPD3	NP_000471.1	AMP_deaminase	137..768	CDD:437158	109/541 (20%)