Protein Alignment Adgf-A2 and Ampd3

DIOPT Version :10

• Sequence 1: NP_525020.2
• Gene: Adgf-A2 / 64879
• FlyBaseID: FBgn0043025
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_001359370.1
• Gene: Ampd3 / 11717
• MGIID: 1096344
• Length: 775
• Species: Mus musculus
• Alignment Length: 547
• Identity: 110/547 - (20%)
• Similarity: 187/547 - (34%)
• Gaps: 163/547 - (29%)

  Fly    58 VLVLICSAPLGENMSNLTSEERHARLRQIYIEKERRQRLGSRMGLSPLEEEANDRLMAIRQVDEE 122
            :|.||...|        |....|.||..:..:....:.|........|:...:.....:|:||..
Mouse   269 ILALITDGP--------TKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTH 325

  Fly   123 FY--------NLWRNYHSQPPPFLKHLNIIDTNLYAALKSMPKGGLLHVHDSGMLRMEILIDLIY 179
            .:        :|.|        |:||....:.:...|.|...|..|..|.||  |.|: ..||..
Mouse   326 IHAAACMNQKHLLR--------FIKHTYQTEPDRTVAEKLGRKITLRQVFDS--LHMD-PYDLTV 379

  Fly   180 RDNLWVCVNLEQDFEDF-RF-SRYFPHIPPAEDYQCNWMLMSNFF--------------QLE-SR 227
             |:|.|... .|.|..| :| |:|.|  ..|.:.:..::...|:.              :|| |:
Mouse   380 -DSLDVHAG-RQTFHRFDKFNSKYNP--VGASELRDLYLKTENYLGGEYFARMVKEVARELEDSK 440

  Fly   228 LEFENRLRKTLTVRPEGYKSSSELARHLRRHQRIIHGLITFRPIWSEFIFTMLSDFYADGVHYVE 292
            .::.   ...|::.....|..|.|||...:|:                       .|:..:.::
Mouse   441 YQYS---EPRLSIYGRSPKEWSSLARWFIQHK-----------------------VYSPNMRWI- 478

  Fly   293 LRSSLPNMYDLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYAPSRNLNDSRMDEYLENAR 357
              ..:|.:||       |..:.:.|.:...:.:|.|..      ::..:.|..|.|
Mouse   479 --IQVPRIYD-------IFRSKKLLPNFGKMLENIFLP------LFKATINPQDHR--------- 519

  Fly   358 LLKLH-FPNFFAGFDL---------NTFGDE-----------------------CNLPLLENVTQ 389
              :|| |..:..|||.         :.|.|:                       .|:.:|.|
Mouse   520 --ELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDLWTSEQNPPYSYYLYYMYANIMVLNN--- 579

  Fly   390 LLRIGKNID-FYF--HAGESRCPDSSRPDANLLEALLLQSKRIGNAVNLPFHPEIMKVMKRLSIA 451
             ||..:.:. |.|  |.||:       .....|.:..|.:..|.:.:.|...|.:..:.....|.
Mouse   580 -LRRERGLSTFLFRPHCGEA-------GSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIP 636

  Fly   452 VEICPLSNHYLQYFNDFRQHPAAYLIAAGFPIVIGSDYPC--FWNSAPLTDDFYVAFVGVISGWG 514
            :.:.||||:.|  |.::.::|....:..|..:.:.:|.|.  .:....|.:::.:|    ...|
Mouse   637 IAMSPLSNNSL--FLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIA----AQVW- 694

  Fly   515 DLRL----LKQFALNSFLFSSLSETEK 537
              :|    |.:.|.||.|.|.||..||
Mouse   695 --KLSTCDLCEIARNSVLQSGLSHQEK 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A2	NP_525020.2	A_deaminase_N	59..152	CDD:462481	18/100 (18%)
		ADGF	135..548	CDD:238646	95/462 (21%)
Ampd3	NP_001359370.1	AMP_deaminase	137..767	CDD:437158	110/547 (20%)