DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-A2 and Ada

DIOPT Version :9

Sequence 1:	NP_525020.2	Gene:	Adgf-A2 / 64879	FlyBaseID:	FBgn0043025	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001258981.1	Gene:	Ada / 11486	MGIID:	87916	Length:	352	Species:	Mus musculus

Alignment Length:	294	Identity:	57/294 - (19%)
Similarity:	106/294 - (36%)	Gaps:	88/294 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 DGVHYVELRSSLPNMY---DLDGNNFTILE---TAEALVSVSNIFKNSFKDFIGIK-------LI 337
            :||.|||:|.| |::.   .:|...:...|   |.:.:|.:.|......:...|||       :.
Mouse    93 EGVVYVEVRYS-PHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMR 156

  Fly   338 YAPSRNLN----------------DSRMDEYLENARLLKLHFPNFFAGFDLNTFGDECNLPLLEN 386
            :.||.:|.                |...||.:|.:.|    ||.....::    |
Mouse   157 HQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSL----FPGHVEAYE----G---------- 203

  Fly   387 VTQLLRIGKNIDFYFHAGESRCPDSSRPDANLLEAL-LLQSKRIGNAVNLPFHPEIMKVMKRLSI 450
                 .:...|....||||...|:..|      ||: :|:::|:|:..:......:...:.:.::
Mouse   204 -----AVKNGIHRTVHAGEVGSPEVVR------EAVDILKTERVGHGYHTIEDEALYNRLLKENM 257

  Fly   451 AVEICPLSNHYLQYFND--------FRQHPAAYLIAAGFPIV----IGSDYPCFWNSAPLTDDFY 503
            ..|:||.|::....::.        |:...|.|.:....|::    :.:||.........|::.:
Mouse   258 HFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEF 322

  Fly   504 VAFVGVISGWGDLRLLKQFALNSFLFSSLSETEK 537
                            |:..:|:...|.|.|.||
Mouse   323 ----------------KRLNINAAKSSFLPEEEK 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A2	NP_525020.2	A_deaminase_N	52..152	CDD:285627
		adm_rel	83..556	CDD:273620	57/294 (19%)
		ADGF	135..548	CDD:238646	57/294 (19%)
Ada	NP_001258981.1	ADA	8..336	CDD:238645	53/288 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810