Protein Alignment Adgf-A2 and ADA

DIOPT Version :10

• Sequence 1: NP_525020.2
• Gene: Adgf-A2 / 64879
• FlyBaseID: FBgn0043025
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_000013.2
• Gene: ADA / 100
• HGNCID: 186
• Length: 363
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 59/299 - (19%)
• Similarity: 105/299 - (35%)
• Gaps: 98/299 - (32%)

  Fly   286 DGVHYVELRSSLPNMY-----------DLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYA 339
            :||.|||:|.| |::.           ..:|:    |...|.:..|....:...:|| |:|
Human    93 EGVVYVEVRYS-PHLLANSKVEPIPWNQAEGD----LTPDEVVALVGQGLQEGERDF-GVK---- 147

  Fly   340 PSRNLNDSRMDEYLENARLL---KLHFPNF---------------FAGFDLNTFGDECNLP---L 383
                            ||.:   ..|.||:               ....||  .||| .:|   |
Human   148 ----------------ARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDL--AGDE-TIPGSSL 193

  Fly   384 LENVTQLLR--IGKNIDFYFHAGESRCPDSSRPDANLLEAL-LLQSKRIGNAVNLPFHPEIMKVM 445
            |....|..:  :...|....||||....:..:      ||: :|:::|:|:..:......:...:
Human   194 LPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVK------EAVDILKTERLGHGYHTLEDQALYNRL 252

  Fly   446 KRLSIAVEICPLSNHYLQYFNDFRQH--------PAAYLIAAGFPIV----IGSDYPCFWNSAPL 498
            ::.::..||||.|::....:....:|        .|.|.:....|::    :.:||.........
Human   253 RQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGF 317

  Fly   499 TDDFYVAFVGVISGWGDLRLLKQFALNSFLFSSLSETEK 537
            |::.:                |:..:|:...|.|.|.||
Human   318 TEEEF----------------KRLNINAAKSSFLPEDEK 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A2	NP_525020.2	A_deaminase_N	59..152	CDD:462481
		ADGF	135..548	CDD:238646	59/299 (20%)
ADA	NP_000013.2	A_deaminase	10..350	CDD:425964	59/299 (20%)
		Required for binding to DDP4. /evidence=ECO:0000269|PubMed:15016824	126..143		2/16 (13%)