Protein Alignment cpx and CPLX1

DIOPT Version :9

• Sequence 1: NP_001262248.1
• Gene: cpx / 64877
• FlyBaseID: FBgn0041605
• Length: 157
• Species: Drosophila melanogaster
• Sequence 2: NP_006642.1
• Gene: CPLX1 / 10815
• HGNCID: 2309
• Length: 134
• Species: Homo sapiens
• Alignment Length: 134
• Identity: 56/134 - (41%)
• Similarity: 72/134 - (53%)
• Gaps: 15/134 - (11%)

  Fly     4 FIAKQMVGNQLSAVKGAVGGDGGDDGDDKEKAEEEERERQEAIKEAEDRRKEKHRKMEEEREKMR 68
            |:.||.:|.....:...:|||...|.|    |.::|.|||||:::||:.||.|:.|||.|||.:|
Human     3 FVMKQALGGATKDMGKMLGGDEEKDPD----AAKKEEERQEALRQAEEERKAKYAKMEAEREAVR 63

  Fly    69 QDIRDKYNIKKKEE-IVEAAPQEEPN---PLMRKKKT-PEELAAEAEQEELDDFTSKSLLPLSSA 128
            |.|||||.|||||| ..||....|.|   .|.|.||. |.....|.|:|:      :|:|.....
Human    64 QGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEED------ESILDTVIK 122

  Fly   129 VEPG 132
            ..||
Human   123 YLPG 126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cpx	NP_001262248.1	Synaphin	2..124	CDD:283491	53/124 (43%)
CPLX1	NP_006642.1	Synaphin	1..133	CDD:310434	56/134 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..60		25/60 (42%)
		Interaction with the SNARE complex. /evidence=ECO:0000250	48..70		14/21 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..113		15/38 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155031
Domainoid	1	1.000	83	1.000	Domainoid score	I8364
eggNOG	1	0.900	-	-		E1_2CF74
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	83	1.000	Inparanoid score	I5190
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42252
orthoMCL	1	0.900	-	-		OOG6_108742
Panther	1	1.100	-	-	O	PTHR16705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4999
SonicParanoid	1	1.000	-	-		X2910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780