DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disco-r and SETD1A

DIOPT Version :9

Sequence 1:	NP_001259598.1	Gene:	disco-r / 64875	FlyBaseID:	FBgn0285879	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_055527.1	Gene:	SETD1A / 9739	HGNCID:	29010	Length:	1707	Species:	Homo sapiens

Alignment Length:	1482	Identity:	275/1482 - (18%)
Similarity:	438/1482 - (29%)	Gaps:	545/1482 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 HPRAAAASEVHRLAAGGSVSPPPPPSTSSSLLYHLPANTNAATAATVATVSASYRHPLQGHERQQ 85
            |..|::||.....|...:.:.....|.|||.|....:::::::::...:..|:|
Human   313 HFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANY----------- 366

  Fly    86 NQHHHPYQHQHHHHYHQHHPHLPTGGGNVHLSRESSPASMVMTPSRRSSPP-----LPPLPLTTH 145
                 |..::..:.|.:|..:.|.     ..:||..|.:.....:....||     |||     .
Human   367 -----PAYYESWNRYQRHTSYPPR-----RATREEPPGAPFAENTAERFPPSYTSYLPP-----E 416

  Fly   146 PIHPHSHSHSHP---HPHPHPLPLALPLRHPLALNANAGGHQSPSRSSGSVQQTSSHAQSSAQS- 206
            |..|....:..|   .|.|.|         |.......||..||.|..   .:||....|.|:|
Human   417 PSRPTDQDYRPPASEAPPPEP---------PEPGGGGGGGGPSPEREE---VRTSPRPASPARSG 469

  Fly   207 --------MSVHFSQLAHAQLH-----LQNQLQQKLSAAASRNNNNNNNNN-----NNNSSSTGS 253
                    .||.|:|  |:.|.     |..:.:.|.|..||.......|::     .:..|...|
Human   470 SPAPETTNESVPFAQ--HSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPS 532

  Fly   254 GTGTGNSTPTHDP--------------------------NPMNPLSDLQNMQPFDFRKISSAAAL 292
            |:|.|..||...|                          |..:|.|...:|:..|..:
Human   533 GSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDR------- 590

  Fly   293 GAFGGPLPLPQSPTE-------------------FGQHHHHSQQQQHQHHLHRNQFFNAMAMAYH 338
              .|.|.|.|..|.:                   .|...|..                    ||.
Human   591 --GGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQP--------------------AYL 633

  Fly   339 LPP-PPPPPPPDSRSPPSPPPGVGQYQHQAGSGSGSGSGSGSGSSSGAGSVDDSAGKQQRNSDKV 402
            ||| |..||||:...||.|||.:..:.:..                   .:.|..|.|.
Human   634 LPPRPDGPPPPEYPPPPPPPPHIYDFVNSL-------------------ELMDRLGAQW------ 673

  Fly   403 SASGSCSS----SQRMTRLALSSNMRSSRKTPHSPGG--GGAGGNG------------------- 442
              .|...|    :|.:|||   ..:|..:....:..|  |||.|..
Human   674 --GGMPMSFQMQTQMLTRL---HQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALY 733

  Fly   443 --GSVGGGGGKRQWGSMPANLGTQFI--NPVTGKK-----RVQCNVCL-KTFCDKGA-------L 490
              |..|.|...|:...:|..:..:.:  :.|:|::     |.:..:.. ||....|.       |
Human   734 AQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAML 798

  Fly   491 KIHFSAVHLREMHKCTVDGCSM-MFSSRRSRNRHSANP---------------NPKLHSPHLRRK 539
            .....::..|::::..|:..:. .|..........|.|               ..||..|.|.
Human   799 VQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLL-- 861

  Fly   540 ISPHDGRSAQPHPLLLQAPNGLMAGLAPFG------------SFPL------------------- 573
                        .|:..|.:|...|:..|.            ||.:
Human   862 ------------SLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRP 914

  Fly   574 LTPPPDLRHHAMGGSGAGSGAGVGALELKHGQDYLQRSYLDAGRFEGQRRK-LAMENEHTE---- 633
            .||..:..........||.....|....|..:        :.|:.:|:.|| .|:::|..|
Human   915 STPAEEDEDDPEQEKEAGEPGRPGTKPPKRDE--------ERGKTQGKHRKSFALDSEGEEASQE 971

  Fly   634 -----DEDDDEILEVGIHMAGDDDDDE---------------ADGDEDEDDDDPDGIVVVGDEID 678
                 ||:|||          :|::||               :|| |||:.|......:..|.
Human   972 SSSEKDEEDDE----------EDEEDEDREEAVDTTKKETEVSDG-EDEESDSSSKCSLYADS-- 1023

  Fly   679 SMPLDHENDNDNENENDESDERSTSAVSSLSQTKEQSSPGKVVQSGLEECHTYAHAHAHALTHGH 743
                |.|||:.:::|:..|...|:|:.||.|.:...||.....:...||
Human  1024 ----DGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEE---------------- 1068

  Fly   744 AHSLGHAHALAQMAANKRKRKSQNPVRCPVQSDENSGENSIDYDVAADLSIKKVRLPAQAAASAK 808
                  ....|..:|:...|:...|...||       |..:...||..   ....||.|.|:.|:
Human  1069 ------ERPAALPSASPPPREVPVPTPAPV-------EVPVPERVAGS---PVTPLPEQEASPAR 1117

  Fly   809 ESEVGESTKSIPSPPLTPYGDLRPVGLCIKTEQDHEQ-----ELDQEQGQERKR------EQEQE 862
            .:  |.:.:|.||.||.|  ...|.|......:..|:     .|.....:.||.      |....
Human  1118 PA--GPTEESPPSAPLRP--PEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPA 1178

  Fly   863 PEPDPV--------ATASKSEMK--------------------------------------LEEQ 881
            |||.|.        ..||:...:                                      .||:
Human  1179 PEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEE 1243

  Fly   882 ETRPA---------------------------DKEDDNEEDEQVSP-PVVTTLDLS-RAAAAIK- 916
            |..|.                           |.|.....||...| |:::.:.|. ..|.|:|
Human  1244 EAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKP 1308

  Fly   917 ---------------------------LEPLEEINYEADENRYVRIKQELMGGDESLAEESSDKT 954
                                       ||..|.:..||:|.:..:::|:...|:|...||..::.
Human  1309 TPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEE 1373

  Fly   955 ANHNNNNNNNNNININNSVRLESDNGLEASELEEREPEPETEIEPEHEHEHEPEPETE-----VE 1014
            ...::::::::.   ..::|..|   |.:.....|.|.|.   .|.....:||..|.|     .:
Human  1374 EESSDSSSSSDG---EGALRRRS---LRSHARRRRPPPPP---PPPPPRAYEPRSEFEQMTILYD 1429

  Fly  1015 VPEVPIDKENP--LKCT-------ACGEIFQNHFHLKTHHQSVHLKL------------HHKCNI 1058
            :....:|.|:.  |:.|       ..|..:.|..|. .||...:|..            .|:...
Human  1430 IWNSGLDSEDMSYLRLTYERLLQQTSGADWLNDTHW-VHHTITNLTTPKRKRRPQDGPREHQTGS 1493

  Fly  1059 DGCNAAFP-SKRSRDRH-----------------------SSNLNLHRKLLSTSDDHGLLHAPVM 1099
            ......:| ||:.:|::                       |...:..|:|||......::.:
Human  1494 ARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRRLLSAIGTSAIMDS--- 1555

  Fly  1100 PATDPLLELMSLNLNNNKSGFHHSAMVGSSAGGAGGVNPAAVGSIQAEILAR 1151
                .||:|..|.....|..|..|.:   ...|...:.|.|...:..|.:.:
Human  1556 ----DLLKLNQLKFRKKKLRFGRSRI---HEWGLFAMEPIAADEMVIEYVGQ 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disco-r	NP_001259598.1	C2H2 Zn finger	1028..1053	CDD:275370	7/43 (16%)
disco-r	NP_001259598.1	C2H2 Zn finger	1056..1083	CDD:275370	5/50 (10%)
SETD1A	NP_055527.1	RRM_Set1A	92..186	CDD:240992
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..363		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..486		30/128 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..655		37/177 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..854		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..1251		83/420 (20%)
		DNA_pol3_delta2	<1070..>1130	CDD:331068	18/71 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1264..1293		6/28 (21%)
		HCFC1-binding motif (HBM)	1299..1303		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1307..1417		19/118 (16%)
		Interaction with CFP1	1415..1450		8/34 (24%)
		N-SET	1425..1562	CDD:314603	23/144 (16%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269\|PubMed:17998332	1450..1537		12/87 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1472..1499		2/26 (8%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	1492..1497		0/4 (0%)
		SET	1568..1691	CDD:214614	7/36 (19%)
		PostSET	1691..1707	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000