Protein Alignment disco-r and bnc2

DIOPT Version :9

• Sequence 1: NP_001259598.1
• Gene: disco-r / 64875
• FlyBaseID: FBgn0285879
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_001314679.1
• Gene: bnc2 / 559327
• ZFINID: ZDB-GENE-030131-5784
• Length: 1268
• Species: Danio rerio
• Alignment Length: 1177
• Identity: 272/1177 - (23%)
• Similarity: 404/1177 - (34%)
• Gaps: 376/1177 - (31%)

  Fly   221 LQNQLQQKLSAAASRNNNNNNN--NNNNNSSSTGSGTGTGNSTPT---HDPNPMNPLSDLQNMQP 280
            :|.:..|.::..:|:.::....  .:||.:.|.|..:...|::|:   |..|..|.|:.|   .|
Zfish   284 IQEKEGQAVTVPSSKTDSGIRTFIESNNRTRSPGLLSHLENNSPSSIHHFENIPNSLAFL---LP 345

  Fly   281 FDFRKISSAAALGAFGGPLPLPQS--------------PTEFGQHHHHSQQQQHQHHLHRNQFFN 331
            |.:....||..||.....|.:.||              |.|      .|:.:......|..|..:
Zfish   346 FQYINPMSAPMLGLPPNGLSIEQSGLRMREPNLPNQSDPVE------ASESEVSLSPFHSGQSPS 404

  Fly   332 AMAMAYHLPPPPPPPPPDSRSPPSPPPGVGQYQHQAGSGSGSGSGSGSGSSSGAGSVDDSAGKQQ 396
            ...|........|...|:..||.||.|...|.| |..:.:....|....||.....:.....|.:
Zfish   405 RGVMGTLPNAIEPKTEPNRASPISPTPSTLQSQ-QPQTPTQQTQGQQQSSSLNNHQIHHHFEKNE 468

  Fly   397 RNSDKVSASGSCSSSQRMTRLALSSNMRSSRKTPHSPGGGGAGGNGGSVGGGGGKRQWGSMPANL 461
            :             |:.:|..:.||.|...|:
Zfish   469 Q-------------SKTITHSSFSSKMHRIRR--------------------------------- 487

  Fly   462 GTQFINPVTGKKRVQCNVCLKTFCDKGALKIHFSAVHLREMHKCTVDGCSMMFSSRRSRNRHSAN 526
                :...:.|.||.||.|.|||.|||.||||::||||:..|:||::||:|:|||.|||||||||
Zfish   488 ----MGATSRKGRVCCNSCGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSAN 548

  Fly   527 PNPKLHSPHLRRK--------------------------ISPHDGRS----AQP--HPLL---LQ 556
            |||:||.|.||..                          .||  ||.    |.|  .|::   ||
Zfish   549 PNPRLHMPMLRNNRDKDLIRSSSGTATPVISSTKSGFNLTSP--GRPPLSFATPPLEPMIQSPLQ 611

  Fly   557 APNGL--MAGLAPFGSFP-----------LLTPPPDLRHHAMGGSGAGSGAGVGALELKHGQDYL 608
            :|...  :..:.|....|           |::||..|....:..:.|.|      ..|...|..|
Zfish   612 SPLVFPSLKSVQPVQPVPPFYRTLLSPADLVSPPVSLPTSPILPTTANS------TSLTDQQQML 670

  Fly   609 QRSYLDAGRFEGQRRKLAMENEHTEDED--------------------DDEILEVGIHMAGDDDD 653
            ..|.|.....|.......:...|:..:.                    :.|:::|.      ||.
Zfish   671 AVSSLSMHVSETSPFSHRLPTNHSTQDSIILDPMPKKKPRKSSMPVKIEKEVIDVA------DDY 729

  Fly   654 DEADGDEDEDDDDPDGIVVVGDEIDSMPLDHENDNDNENENDESDERSTSAVSSLSQTKEQSSPG 718
            |    |:||||||.|
Zfish   730 D----DKDEDDDDGD-------------------------------------------------- 740

  Fly   719 KVVQSGLEECHTYAHAHAHALTHGHAHSLGHAHALAQMAANKRKRKSQNPVRCPVQSDENSGENS 783
                    .||           | |.|.....|.:.....|.....|.:...|     ..||..|
Zfish   741 --------SCH-----------H-HHHQPSSIHNVNGNCNNNNNGSSSSSHHC-----GGSGHES 780

  Fly   784 IDYDVAADLSIKKVRLPAQAAASAKESEVGESTKSIPSPPLTPYGDLRPVGLCIKTEQDHEQELD 848
            ..:|   ::|      |:||.......|..|.|.|...   ..:||||.:......:||||::.:
Zfish   781 PSHD---EMS------PSQALRGMLHPEQEECTGSHGG---RGHGDLRCIDSFTSEDQDHERDFE 833

  Fly   849 QEQ--GQERKREQEQEPEPDPVATASKSEMKLEEQETRPADKEDDNE-----EDEQVSPPVVTTL 906
            .|.  .:.:...:::..:.|...||....|..|.|.|     |||..     ::...|||
Zfish   834 NESETSESKMLYRDELMDTDINQTALGKNMDKEHQGT-----EDDQHLRKDLDEHSHSPP----- 888

  Fly   907 DLSRAAAAIKLEPLEEINYEADENRYVRIKQELM-GGDESLAEESSDKTANHNNNNNNNNNININ 970
              |:....||::  |||| :...:.:...:..|. ||..:.|..::...|.|
Zfish   889 --SQHQPVIKIK--EEIN-DPTYDMFCMGQYSLYNGGMAAAAAAAASMAALH------------- 935

  Fly   971 NSVRLESDNGLEASELEEREPEPETEIEPEHEHEHEPEPETEVEVPEVPIDKENPLKCTACGEIF 1035
            .|.......|....:...:.||.:....|:                        |..|..|.:.|
Zfish   936 ESFISSMSYGTSTPKFPSQSPEGDLCSSPD------------------------PKICYVCKKSF 976

  Fly  1036 QNHFHLKTHHQSVHLKLHHKCNIDGCNAAFPSKRSRDRHSSNLNLHRKLLSTSDDHGLLHAPVMP 1100
            ::.:.:|.|:::||||..|.|.:.||||||||:|||||||||:|||||||:...|..:|
Zfish   977 KSSYSVKLHYKNVHLKEMHVCTVSGCNAAFPSRRSRDRHSSNINLHRKLLTKELDDIVL------ 1035

  Fly  1101 ATDPLLELMSLNLNNNKSGF-------HHSAMVGSSAGGAGGVNPAAVG--SIQAEILARIC-AG 1155
              ||.|..:...|   ::.|       ||:.:.|  .||.....|.:.|  .:::::..... :.
Zfish  1036 --DPQLTTLPKQL---RAEFLSKIYADHHTGLEG--VGGFDNGPPQSRGHEGMRSQVAREYSHSN 1093

  Fly  1156 AHAHGLN---VPL---CFEALQHRFAVGHGH-----AGYPLIAGDGSPPSPRLFLNHGGGASPLL 1209
            .:.||.|   |.|   ...::|...:|...|     :...::..|....|.........||..|.
Zfish  1094 GYCHGPNDDYVVLDLSTASSVQSSGSVQSSHESDEGSDEGILLDDLEDASDTEDCTPSTGAQRLS 1158

  Fly  1210 FAGLPR----------------MPRFPQLTPHMLAASAGNTAAAAAAAAAAAAGMGG-LSPFCRR 1257
            ..|..|                :...|.::|.:||:|.||             |.|| |...|.:
Zfish  1159 MEGKNREEAGKEEREGETDERILHYDPSVSPSILASSGGN-------------GTGGILCTICHK 1210

  Fly  1258 TSSDSNS 1264
            ..|:..:
Zfish  1211 LYSNKGT 1217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
disco-r	NP_001259598.1	C2H2 Zn finger	1028..1053	CDD:275370	9/24 (38%)
		C2H2 Zn finger	1056..1083	CDD:275370	21/26 (81%)
bnc2	NP_001314679.1	C2H2 Zn finger	499..520	CDD:275368	14/20 (70%)
		C2H2 Zn finger	527..545	CDD:275368	12/17 (71%)
		PARM	<578..>723	CDD:293666	26/152 (17%)
		C2H2 Zn finger	1205..1226	CDD:275368	2/13 (15%)
		C2H2 Zn finger	1233..1251	CDD:275368

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594784
Domainoid	1	1.000	200	1.000	Domainoid score	I2982
eggNOG	1	0.900	-	-		E1_2C0EZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3735
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D59377at33208
OrthoFinder	1	1.000	-	-		FOG0002551
OrthoInspector	1	1.000	-	-		otm26341
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15021
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3798
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.980