DRSC/TRiP Functional Genomics Resources

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Protein Alignment disco-r and BNC2

DIOPT Version :9

Sequence 1:NP_001259598.1 Gene:disco-r / 64875 FlyBaseID:FBgn0285879 Length:1311 Species:Drosophila melanogaster
Sequence 2:NP_060107.3 Gene:BNC2 / 54796 HGNCID:30988 Length:1099 Species:Homo sapiens


Alignment Length:1137 Identity:240/1137 - (21%)
Similarity:352/1137 - (30%) Gaps:503/1137 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 LQNQLQQKLSAAASRNNNNNNN--NNNNNSSSTGSGTGTGNSTPT---HDPNPMNPLSDLQNMQP 280
            :|.:..|.::..:|:.:::...  .:||.:.|........||.|:   |..|..|.|:.|   .|
Human   263 IQEKEGQAVAVPSSKTDSDIRTFIESNNRTRSPSLLAHLENSNPSSIHHFENIPNSLAFL---LP 324

  Fly   281 FDFRKISSAAALGAFGGPLPLPQSPTEFGQHHHHSQQQQHQHHLHRNQFFNAMAMAYHLPPPPPP 345
            |.:....||..||.....|.|.|......:....:|.:.::                        
Human   325 FQYINPVSAPLLGLPPNGLLLEQPGLRLREPSLSTQNEYNE------------------------ 365

  Fly   346 PPPDSRSPPSPPPGVGQYQHQAGSGSGSGSGSGSGSSSGAGSVDDSAGKQQRNSDKVSASGSCSS 410
               .|.|..||.|    |::                       |.:..:        :|..|.::
Human   366 ---SSESEVSPTP----YKN-----------------------DQTPNR--------NALTSITN 392

  Fly   411 SQRMTRLALSSNMRSS------RKTPHSPGGGGAGGNGGSVGGGGGKRQWGSMPANLGTQFINPV 469
            .:..|..|..|.:::|      .||.|.......          ...|:.||            .
Human   393 VEPKTEPACVSPIQNSAPVSDLTKTEHPKSSFRI----------HRMRRMGS------------A 435

  Fly   470 TGKKRVQCNVCLKTFCDKGALKIHFSAVHLREMHKCTVDGCSMMFSSRRSRNRHSANPNPKLHSP 534
            :.|.||.||.|.|||.|||.||||::||||:..|:||::||:|:|||.||||||||||||:||.|
Human   436 SRKGRVFCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRLHMP 500

  Fly   535 HLRRK-----ISPHDGRSAQPHPLLLQAPNGL---MAGLAPFGSFPLLTPPPD-LRHHAMGGSGA 590
            .||..     |....|.:.   |::....:.|   ..|..|.|   ..|||.| :..:.:.....
Human   501 MLRNNRDKDLIRATSGAAT---PVIASTKSNLALTSPGRPPMG---FTTPPLDPVLQNPLPSQLV 559

  Fly   591 GSGAGVGALELKHGQDY--LQRSYLDAGRFEGQRRKL--------------------------AM 627
            .||       ||..|..  ..||.|..|........|                          .|
Human   560 FSG-------LKTVQPVPPFYRSLLTPGEMVSPPTSLPTSPIIPTSGTIEQHPPPPSEPVVPAVM 617

  Fly   628 ENEHTEDED----------------DDEILEVGIHMAGDDDDDEADGDEDEDDDDPDGIVVVGDE 676
            ...|....|                :.||:            |.||..:|||||..||..||.| 
Human   618 MATHEPSADLAPKKKPRKSSMPVKIEKEII------------DTADEFDDEDDDPNDGGAVVND- 669

  Fly   677 IDSMPLDHENDNDNENENDESDERSTSAVSSLSQTKEQSSPGKVVQSGLEECHTYAHAHAHALTH 741
                 :.|:|.                     ..::|:.|||..|                    
Human   670 -----MSHDNH---------------------CHSQEEMSPGMSV-------------------- 688

  Fly   742 GHAHSLGHAHALAQMAANKRKRKSQNPVRCPVQSDENSGENSIDYDVAADLSIKKVRLPAQAAAS 806
                               :.....|..||                    :|..::|     .|.
Human   689 -------------------KDFSKHNRTRC--------------------ISRTEIR-----RAD 709

  Fly   807 AKESEVGESTKSIPSPPLTPYGDLRPVGLCIKTEQDHEQELDQEQGQERKREQEQEPEPDPVATA 871
            :..||                                                :||||.|....:
Human   710 SMTSE------------------------------------------------DQEPERDYENES 726

  Fly   872 SKSEMKLEEQETRPADKEDDNEEDEQVSPPVVTTLDLSRAAAAIKLEPLEEINYEADENRYVRIK 936
            ..||.||.| |:...|:...:|..|:|               .:..|..:|.:.|......:::|
Human   727 ESSEPKLGE-ESMEGDEHIHSEVSEKV---------------LMNSERPDENHSEPSHQDVIKVK 775

  Fly   937 QELM----------------GGDESLA--EESSDKTANHNNNNNNNNNININNSVRLESDNGLEA 983
            :|..                ||..|:|  .||...:.|:.:                        
Human   776 EEFTDPTYDMFYMSQYGLYNGGGASMAALHESFTSSLNYGS------------------------ 816

  Fly   984 SELEEREPEPETEIEPEHEHEHEPEPETEVEVPEVPIDKENPLKCTACGEIFQNHFHLKTHHQSV 1048
                     |: :..||.:....|:|:.                |..|.:.|::.:.:|.|:::|
Human   817 ---------PQ-KFSPEGDLCSSPDPKI----------------CYVCKKSFKSSYSVKLHYRNV 855

  Fly  1049 HLKLHHKCNIDGCNAAFPSKRSRDRHSSNLNLHRKLLSTS-DDHGL------------------L 1094
            |||..|.|.:.||||||||:|||||||:|:|||||||:.. ||.||                  :
Human   856 HLKEMHVCTVAGCNAAFPSRRSRDRHSANINLHRKLLTKELDDMGLDSSQPSLSKDLRDEFLVKI 920

  Fly  1095 HAPVMP--------ATDP--------------------LLELMSLNLNNNKSGFHHSAMVGSSAG 1131
            :....|        |:.|                    :|:|.:.:...:.|..|.|.  .|.||
Human   921 YGAQHPMGLDVREDASSPAGTEDSHLNGYGRGMAEDYMVLDLSTTSSLQSSSSIHSSR--ESDAG 983

  Fly  1132 GAGGV-------------------NPAAVGSIQAE----------------ILARICAGAHA--- 1158
            ...|:                   .||..||:.||                |:..||...::   
Human   984 SDEGILLDDIDGASDSGESAHKAEAPALPGSLGAEVSGSLMFSSLSGSNGGIMCNICHKMYSNKG 1048

  Fly  1159 --------------HGLNVPLC---FEALQHR 1173
                          |...||.|   |.:::.|
Human  1049 TLRVHYKTVHLREMHKCKVPGCNMMFSSVRSR 1080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
disco-rNP_001259598.1 C2H2 Zn finger 1028..1053 CDD:275370 9/24 (38%)
C2H2 Zn finger 1056..1083 CDD:275370 20/26 (77%)
BNC2NP_060107.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..66
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..385 8/89 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..423 7/25 (28%)
C2H2 Zn finger 443..464 CDD:275368 14/20 (70%)
C2H2 Zn finger 471..489 CDD:275368 12/17 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 622..641 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..742 39/233 (17%)
C2H2 Zn finger 835..856 CDD:275368 5/20 (25%)
C2H2 Zn finger 863..881 CDD:275368 13/17 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 929..948 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1008 7/41 (17%)
C2H2 Zn finger 1037..1058 CDD:275368 2/20 (10%)
C2H2 Zn finger 1065..1083 CDD:275368 5/16 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1079..1099 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158832
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2C0EZ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7987
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D59377at33208
OrthoFinder 1 1.000 - - FOG0002551
OrthoInspector 1 1.000 - - mtm8668
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15021
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3798
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.880

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