DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disco-r and Bnc2

DIOPT Version :9

Sequence 1:	NP_001259598.1	Gene:	disco-r / 64875	FlyBaseID:	FBgn0285879	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_001100136.1	Gene:	Bnc2 / 298189	RGDID:	1310694	Length:	1106	Species:	Rattus norvegicus

Alignment Length:	931	Identity:	210/931 - (22%)
Similarity:	310/931 - (33%)	Gaps:	350/931 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 LQNQLQQKLSAAASRNNNNNNN--NNNNNSSSTGSGTGTGNSTPT---HDPNPMNPLSDLQNMQP 280
            :|.:..|.::..:|:.:::...  .:||.:.|........||.|:   |..|..|.|:.|   .|
  Rat   270 IQEKEGQAVAVPSSKTDSDIRTFIESNNRTRSPSLLAHLENSNPSSIHHFENIPNSLAFL---LP 331

  Fly   281 FDFRKISSAAALGAFGGPLPLPQSPTEFGQHHHHSQQQQHQHHLHRNQFFNAMAMAYHLPPPPPP 345
            |.:....||..||.....|.|.|......:....:|.:           :|..:.:...|.|...
  Rat   332 FQYINPVSAPLLGLPPNGLLLEQPGLRLREPSISTQNE-----------YNESSESEVSPTPYKS 385

  Fly   346 PPPDSRS---------PPSPPPGVGQYQHQAGSGSGSGSGSGSGSSSGAGSVDD-SAGKQQRNSD 400
            ....:|:         |.:.|..|...|:.|                   .|.| |..:..::|.
  Rat   386 DQTPNRNALTSITNVEPKTEPACVSPIQNSA-------------------PVSDLSKPEHPKSSF 431

  Fly   401 KVSASGSCSSSQRMTRLALSSNMRSSRKTPHSPGGGGAGGNGGSVGGGGGKRQWGSMPANLGTQF 465
            ::         .||.|:..:|.
  Rat   432 RI---------HRMRRMGSASR------------------------------------------- 444

  Fly   466 INPVTGKKRVQCNVCLKTFCDKGALKIHFSAVHLREMHKCTVDGCSMMFSSRRSRNRHSANPNPK 530
                  |.||.||.|.|||.|||.||||::||||:..|:||::||:|:|||.||||||||||||:
  Rat   445 ------KGRVFCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPR 503

  Fly   531 LHSPHLRRK-----ISPHDGRSAQPHPLLLQAPNGL---MAGLAPFGSFPLLTPPPD-LRHHAMG 586
            ||.|.||..     |....|.:.   |::....:.|   ..|..|.|   ..|||.| :..:.:.
  Rat   504 LHMPMLRNNRDKDLIRATSGAAT---PVIASTKSNLTLTSPGRPPMG---FTTPPLDPVLQNPLP 562

  Fly   587 GSGAGSGAGVGALELKHGQDY--LQRSYLDAGRFEGQRRKLAME---------NEHTEDEDDDEI 640
            .....||       ||..|..  ..||.|..|........|...         .:|.....:..:
  Rat   563 SQLVFSG-------LKTVQPVPPFYRSLLTPGEMVSPPTSLPTSPIIPTSGTIEQHPPPPSEPIV 620

  Fly   641 --LEVGIHMAGDD-------------------DDDEADGDEDEDDDDPDGIVVVGDEIDSMPLDH 684
              :.:|.|..|.|                   ..|.||..:|||||..||..||.|      :.|
  Rat   621 PAVMMGTHEPGADLAPKKKPRKSSMPVKIEKEIIDTADEFDDEDDDPNDGGTVVND------MSH 679

  Fly   685 ENDNDNENENDESDERSTSAVSSLSQTKEQSSPGKVVQSGLEECHTYAHAHAHALTHGHAHSLGH 749
            .|.                     ..::::.|||..|:...:              |.....:..
  Rat   680 GNH---------------------CHSQDEMSPGMSVKDFSK--------------HNRTRCISR 709

  Fly   750 AHALAQMAANKRKRKSQNPVRCPVQSDENSGENSIDYDVAADLSIKKVRLPAQAAASAKESEVGE 814
            ...   ..|:....:.|.|.|    ..||..|:|                         |.::||
  Rat   710 TEI---RRADSMTSEDQEPER----DYENESESS-------------------------EPKLGE 742

  Fly   815 STKSIPSPPLTPYGDLRPVGLCIKTEQDHEQELDQE-QGQERKREQEQEPEPDPVATASKSEMKL 878
            .:                   .::.|..|.:..|:. ...||..|...||....|       :|:
  Rat   743 ES-------------------MVEDEHIHSEVSDKVLMNSERADENHSEPSHQDV-------IKV 781

  Fly   879 EEQETRPADKEDDNEEDEQVSPPVVTTLDLSRAAAAIKLEPLEEINYEADENRYVRIKQELMGGD 943
            :|:.|                                  :|..::.|.:....|       .||.
  Rat   782 KEEFT----------------------------------DPTYDMFYMSQYGLY-------NGGG 805

  Fly   944 ESLAEESSDKTANHNNNNNNNNNININNSVRLESDNGLEASELEEREPEPETEIEPEHEHEHEPE 1008
            .|:|       |.|::                      ..|.|....|:   :..||.:....|:
  Rat   806 ASMA-------ALHDS----------------------FTSSLNYGSPQ---KFSPEGDLCSSPD 838

  Fly  1009 PETEVEVPEVPIDKENPLKCTACGEIFQNHFHLKTHHQSVHLKLHHKCNIDGCNAAFPSKRSRDR 1073
            |:.                |..|.:.|::.:.:|.|:::||||..|.|.:.||||||||:|||||
  Rat   839 PKI----------------CYVCKKSFKSSYSVKLHYRNVHLKEMHVCTVAGCNAAFPSRRSRDR 887

  Fly  1074 HSSNLNLHRKLLSTS-DDHGL 1093
            ||:|:|||||||:.. ||.||
  Rat   888 HSANINLHRKLLTKELDDMGL 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disco-r	NP_001259598.1	C2H2 Zn finger	1028..1053	CDD:275370	9/24 (38%)
disco-r	NP_001259598.1	C2H2 Zn finger	1056..1083	CDD:275370	20/26 (77%)
Bnc2	NP_001100136.1	C2H2 Zn finger	450..471	CDD:275368	14/20 (70%)
		C2H2 Zn finger	478..496	CDD:275368	12/17 (71%)
		C2H2 Zn finger	842..863	CDD:275368	5/20 (25%)
		C2H2 Zn finger	870..888	CDD:275368	13/17 (76%)
		C2H2 Zn finger	1044..1065	CDD:275368
		C2H2 Zn finger	1072..1090	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C0EZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D59377at33208
OrthoFinder	1	1.000	-	-		FOG0002551
OrthoInspector	1	1.000	-	-		mtm9145
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15021
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940