DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disco-r and Bnc2

DIOPT Version :9

Sequence 1:	NP_001259598.1	Gene:	disco-r / 64875	FlyBaseID:	FBgn0285879	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	XP_017175693.1	Gene:	Bnc2 / 242509	MGIID:	2443805	Length:	1156	Species:	Mus musculus

Alignment Length:	1037	Identity:	217/1037 - (20%)
Similarity:	325/1037 - (31%)	Gaps:	442/1037 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 LQNQLQQKLSAAASRNNNNNNN--NNNNNSSSTGSGTGTGNSTPT---HDPNPMNPLSDLQNMQP 280
            :|.:..|.::..:|:.:::...  .:||.:.|........||.|:   |..|..|.|:.|   .|
Mouse   298 IQEKEGQAVAVPSSKTDSDIRTFIESNNRTRSPSLLAHLENSNPSSIHHFENIPNSLAFL---LP 359

  Fly   281 FDFRKISSAAALGAFGGPLPLPQSPTEFGQHHHHSQQQQHQHHLHRNQFFNAMAMAYHLPPPPPP 345
            |.:....||..||.....|.|.|......:....:|.:           :|..:.:...|.|...
Mouse   360 FQYINPVSAPLLGLPPNGLLLEQPGLRLREPSISTQNE-----------YNESSESEVSPTPYKS 413

  Fly   346 PPPDSRS---------PPSPPPGVGQYQHQAGSGSGSGSGSGSGSSSGAGSVDDSAGKQQRNSDK 401
            ....:|:         |.:.|..|...|:.|                   .|.|
Mouse   414 DQTPNRNALTSITNVEPKTEPACVSPIQNSA-------------------PVSD----------- 448

  Fly   402 VSASGSCSSSQRMTRLALSSNMRSSRKTPHSPGGGGAGGNGGSVGGGGGKRQWGSMPANLGTQFI 466
            :|.:....||.|:.|:                                  |:.||
Mouse   449 LSKTEHPKSSFRIHRM----------------------------------RRMGS---------- 469

  Fly   467 NPVTGKKRVQCNVCLKTFCDKGALKIHFSAVHLREMHKCTVDGCSMMFSSRRSRNRHSANPNPKL 531
              .:.|.||.||.|.|||.|||.||||::||||:..|:||::||:|:|||.||||||||||||:|
Mouse   470 --ASRKGRVFCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRL 532

  Fly   532 HSPHLRRK-----ISPHDGRSAQPHPLLLQAPNGL---MAGLAPFGSFPLLTPPPD-LRHHAMGG 587
            |.|.||..     |....|.:.   |::....:.|   ..|..|.|   ..|||.| :..:.:..
Mouse   533 HMPMLRNNRDKDLIRATSGAAT---PVIASTKSNLTLTSPGRPPMG---FTTPPLDPVLQNPLPS 591

  Fly   588 SGAGSGAGVGALELKHGQDY--LQRSYLDAGRFEGQRRKLAME---------NEHTEDEDDDEI- 640
            ....||       ||..|..  ..||.|..|........|...         .:|.....:..:
Mouse   592 QLVFSG-------LKTVQPVPPFYRSLLTPGEMVSPPTSLPTSPIIPTSGTIEQHPPPPSEPIVP 649

  Fly   641 -LEVGIHMAGDD-------------------DDDEADGDEDEDDDDPDGIVVVGDEIDSMPLDHE 685
             :.:|.|....|                   ..|.||..:|||||..||..||.|      :.|:
Mouse   650 AVMMGTHEPSADLAPKKKPRKSSMPVKIEKEIIDTADEFDDEDDDPNDGGTVVND------MSHD 708

  Fly   686 NDNDNENENDESDERSTSAVSSLSQTKEQSSPGKVVQSGLEECHTYAHAHAHALTHGHAHSLGHA 750
            |.                     ..::::.|||..|
Mouse   709 NH---------------------CHSQDEMSPGMSV----------------------------- 723

  Fly   751 HALAQMAANKRKRKSQNPVRCPVQSDENSGENSIDYDVAADLSIKKVRLPAQAAASAKESEVGES 815
                      :.....|..||                    :|..::|     .|.:..||
Mouse   724 ----------KDFSKHNRTRC--------------------ISRTEIR-----RADSMTSE---- 749

  Fly   816 TKSIPSPPLTPYGDLRPVGLCIKTEQDHEQELDQEQGQERKREQEQEPEPDPVATASKSEMKLEE 880
                                                        :||||.|....:..||.||.|
Mouse   750 --------------------------------------------DQEPERDYENESESSEPKLGE 770

  Fly   881 QETRPADKEDDNEEDEQVSPPVVTTLDLSRAAAAIKLEPLEEINYEADENRYVRIKQELM----- 940
            :     ..|.|.....:||..|:           :..|..:|.:.|......:::|:|..
Mouse   771 E-----SMEGDEHLHSEVSEKVL-----------MNSERPDENHSEPSHQDVIKVKEEFTDPTYD 819

  Fly   941 -----------GGDESLA--EESSDKTANHNNNNNNNNNININNSVRLESDNGLEASELEEREPE 992
                       ||..|:|  .||...:.|:.:
Mouse   820 MFYMSQYGLYNGGGASMAALHESFTSSLNYGS--------------------------------- 851

  Fly   993 PETEIEPEHEHEHEPEPETEVEVPEVPIDKENPLKCTACGEIFQNHFHLKTHHQSVHLKLHHKCN 1057
            |: :..||.:....|:|:.                |..|.:.|::.:.:|.|:::||||..|.|.
Mouse   852 PQ-KFSPEGDLCSSPDPKI----------------CYVCKKSFKSSYSVKLHYRNVHLKEMHVCT 899

  Fly  1058 IDGCNAAFPSKRSRD----------------------RHSSNLNLHRKLLSTSDDHGLLHAPVMP 1100
            :.||||||||:||||                      |||:|:|||||||:.
Mouse   900 VAGCNAAFPSRRSRDRNRNLRMERTIGPGHRDSLHCRRHSANINLHRKLLTK------------- 951

  Fly  1101 ATDPLLELMSLNLNNNKSGFHHSAMVGSSAGGAGGVNPAAVGSIQAEILARICAGAHAHGLN 1162
                  ||..::|::::                    |:....::.|.|.:|....|..||:
Mouse   952 ------ELDDMSLDSSQ--------------------PSLSKDLRDEFLMKIYGAQHPLGLD 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disco-r	NP_001259598.1	C2H2 Zn finger	1028..1053	CDD:275370	9/24 (38%)
disco-r	NP_001259598.1	C2H2 Zn finger	1056..1083	CDD:275370	20/48 (42%)
Bnc2	XP_017175693.1	C2H2 Zn finger	478..499	CDD:275368	14/20 (70%)
		C2H2 Zn finger	506..524	CDD:275368	12/17 (71%)
		C2H2 Zn finger	1094..1115	CDD:275368
		C2H2 Zn finger	1122..1140	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C0EZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7987
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002551
OrthoInspector	1	1.000	-	-		mtm8901
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15021
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3798
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.870