DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disco-r and bnc2

DIOPT Version :9

Sequence 1:	NP_001259598.1	Gene:	disco-r / 64875	FlyBaseID:	FBgn0285879	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	XP_002935715.2	Gene:	bnc2 / 100494907	XenbaseID:	XB-GENE-953157	Length:	1022	Species:	Xenopus tropicalis

Alignment Length:	995	Identity:	207/995 - (20%)
Similarity:	334/995 - (33%)	Gaps:	377/995 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 LQNQLQQKLSAAASRNNNNNNN--NNNNNSSSTGSGTGTGNSTPT---HDPNPMNPLSDLQNMQP 280
            :|.:..|.::..:|:.:::...  .|||.:.|..:.:...||.|:   |..|..|.|:.|   .|
Frog   185 IQEKEGQAVAVPSSKADSDIRTFIENNNRTRSPSALSHLENSNPSSIHHFENMPNSLAFL---LP 246

  Fly   281 FDFRKISSAAALGAFGGPLPLP------QSPTEFGQH--HHHSQQQQHQHHLHRNQ---FFNAMA 334
            |.:....||..||.....|.|.      :.|:...|:  ...|:.:.......||:   ..||::
Frog   247 FQYINPVSAPMLGLPPNGLMLEHPGLRLREPSNSNQNECEESSESEVSPMPYSRNEQPSNRNALS 311

  Fly   335 MAYHLPPPPPPPPPDSRSPPSPPPGVGQYQHQAGSGSGSGSGSGSGSSSGAGSVDDSAGKQQRNS 399
            ...::.|...|.........:|...:.:.:|                              .:.|
Frog   312 SITNVEPKTEPTNASPTQCSTPVSEINKSEH------------------------------TKTS 346

  Fly   400 DKVSASGSCSSSQRMTRLALSSNMRSSRKTPHSPGGGGAGGNGGSVGGGGGKRQWGSMPANLGTQ 464
            .|:         .||.|:..||.
Frog   347 FKI---------HRMRRMGSSSR------------------------------------------ 360

  Fly   465 FINPVTGKKRVQCNVCLKTFCDKGALKIHFSAVHLREMHKCTVDGCSMMFSSRRSRNRHSANPNP 529
                   |.||.||.|.|||.|||.||||::||||:..|:||::||:|:|||.||||||||||||
Frog   361 -------KGRVFCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNP 418

  Fly   530 KLHSPHLRRK-----ISPHDGRSAQPHPLLLQAPNGL---MAGLAPFGSFPLLTPPPD------L 580
            :||.|.||..     |....|.:.   |::....:.|   ..|..|.|   ..|||.|      |
Frog   419 RLHMPMLRNNRDKDLIRATSGAAT---PVIASTKSSLTLTSPGRPPLG---FSTPPLDPILQNTL 477

  Fly   581 RHHAMGGSGAGSGAGVGALELKHGQDYLQRSYLDAGRFE----------------GQRRKLAM-E 628
            .:|.:          ..||:.........||.|::|...                |..:.|.: .
Frog   478 SNHLV----------FPALKTVQPVPPFYRSLLNSGDMVSPPTSLPTSPIMPSSLGVEQPLPLPP 532

  Fly   629 NEHTEDEDDDEILEVGIHMAGDDDDDEADGDEDEDDDDPDGIVVVGDEIDSMPLDHENDNDNENE 693
            :.....|....::.|.||   |.:.|:|...:......|   |.:..|:    :|..::.|.|.|
Frog   533 SLPLPSELSGSMIGVTIH---DSNADQAPKKKPRKSSMP---VKIEKEV----IDTADEFDEEEE 587

  Fly   694 NDESDERSTSAVSSLSQTKEQSSPGKVVQSGLEECHTYAHAHAHALTHGHAHSLGHAHALAQMAA 758
            .:.....||:.:...|.:::..|||..|.|
Frog   588 ENIDHGPSTNDMGHDSHSQDDMSPGLSVNS----------------------------------- 617

  Fly   759 NKRKRKSQNPVRCPVQSDENSGENSIDYDVAADLSIKKVRLPAQAAASAKESEVGESTKSIPSPP 823
                            ..:|||...|.            |...:|.:...|
Frog   618 ----------------FSKNSGSRCIR------------RTDTRANSVTSE-------------- 640

  Fly   824 LTPYGDLRPVGLCIKTEQDHEQELDQEQGQERKREQEQEPEPDPVATASKSEMKLEEQETRPADK 888
                            :|:|:::.:.|......:..::..|.|        .:.|.::.:..:..
Frog   641 ----------------DQEHDRDFENESVSSEPKYCDEPMEDD--------HLPLHKEHSVRSMM 681

  Fly   889 EDDNEEDEQVSPPVVTTLDLSRAAAAIKL-----EPLEEINYEADENRYVRIKQELMGGDESLAE 948
            ::|...:..:.         ....|.||:     :|..::.|.:....|
Frog   682 DNDKSYENHID---------CHQQAVIKVKEEFTDPAYDMFYMSHYGLY---------------- 721

  Fly   949 ESSDKTANHNNNNNNNNNININNSVRLESDNGLEASELEEREPEPETEIEPEHEHEHEPEPETEV 1013
                       |.|:.:...::.|:         ||.|....|   .:..||.:....|:|:.
Frog   722 -----------NGNSASMAALHESL---------ASSLNYGSP---PKFSPEGDLCSSPDPKI-- 761

  Fly  1014 EVPEVPIDKENPLKCTACGEIFQNHFHLKTHHQSVHLKLHHKCNIDGCNAAFPSKRSRDRHSSNL 1078
                          |..|.:.|::.:.:|.|:::||||..|.|.:.||||||||:|||||||:|:
Frog   762 --------------CYVCKKSFKSSYSVKLHYKNVHLKEMHVCTVAGCNAAFPSRRSRDRHSANI 812

  Fly  1079 NLHRKLLSTSDDHGLLHAPVMPATDPLLELMSLNLNNNKSGFHHSAMVGSSAGGAGGVNPAAVGS 1143
            |||||||:.                   ||..:.|::::.                        :
Frog   813 NLHRKLLTK-------------------ELDEMGLDSSQP------------------------T 834

  Fly  1144 IQAEILARICAGAHAHGLNV 1163
            ::.|.||:|..|.|..||:|
Frog   835 LRDEFLAKIYGGQHPLGLDV 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disco-r	NP_001259598.1	C2H2 Zn finger	1028..1053	CDD:275370	9/24 (38%)
disco-r	NP_001259598.1	C2H2 Zn finger	1056..1083	CDD:275370	20/26 (77%)
bnc2	XP_002935715.2	C2H2 Zn finger	366..387	CDD:275368	14/20 (70%)
		C2H2 Zn finger	394..412	CDD:275368	12/17 (71%)
		C2H2 Zn finger	762..783	CDD:275368	5/20 (25%)
		C2H2 Zn finger	790..808	CDD:275368	13/17 (76%)
		C2H2 Zn finger	960..981	CDD:275368
		C2H2 Zn finger	988..1006	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D59377at33208
OrthoFinder	1	1.000	-	-		FOG0002551
OrthoInspector	1	1.000	-	-		mtm9561
Panther	1	1.100	-	-	O	PTHR15021
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3798
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.140