DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2D and Mcts2

DIOPT Version :9

Sequence 1:	NP_477481.1	Gene:	eIF2D / 64874	FlyBaseID:	FBgn0041588	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_079819.1	Gene:	Mcts2 / 66405	MGIID:	1913655	Length:	181	Species:	Mus musculus

Alignment Length:	184	Identity:	49/184 - (26%)
Similarity:	82/184 - (44%)	Gaps:	15/184 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLKPYRPKSSAA----LKGSDSKKFRQRVEAAFPHVS--VDQLVPAKAAVTQVKILTHGGVQSM 59
            || |.:..|.|.:    ||.|..|..:.::...||.:.  ::|::|.|..|..|:...|    ..
Mouse     1 MF-KKFDEKESVSNCIQLKTSVIKGIKSQLTEQFPGIEPWLNQIMPKKDPVKIVRCHEH----ME 60

  Fly    60 VYCVDKLPLFFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVGLSM 124
            :..|:...|||....|...|||..|...|.|||:....:|.:..:.:||::|.||:...|..|..
Mouse    61 ILTVNGELLFFRQRKGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYT 125

  Fly   125 YGHFKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLW 178
            ..   ...::||.....:.|:.||.:..::.::... ..|:.|:.:|...|.||
Mouse   126 AA---VDTIVAVMAEGKEHALCVGVMKMAAADIEKI-NKGIGIENIHYLNDGLW 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	19/78 (24%)
		Tma20	9..178	CDD:224927	44/174 (25%)
		PUA	61..175	CDD:294405	29/113 (26%)
		eIF2D_C	469..551	CDD:211321
Mcts2	NP_079819.1	MCT1_N	4..80	CDD:211422	19/79 (24%)
Mcts2	NP_079819.1	PUA_MCTS-1-like	80..175	CDD:409297	25/98 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2016
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810