Protein Alignment eIF2D and Eif2d

DIOPT Version :10

• Sequence 1: NP_477481.1
• Gene: eIF2D / 64874
• FlyBaseID: FBgn0041588
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: NP_001017489.1
• Gene: Eif2d / 498225
• RGDID: 1561765
• Length: 570
• Species: Rattus norvegicus
• Alignment Length: 611
• Identity: 202/611 - (33%)
• Similarity: 297/611 - (48%)
• Gaps: 93/611 - (15%)

  Fly     1 MFLKPYRPKSSAALKGSDSKKFRQRVEAAFPHVSVDQ---LVPAKAAVTQVKILTHGGVQSMVYC 62
            ||.|.:|.||:.|:||||.:|.|..|..|||.:..||   |:|.|..:..||:..|.|....||.
  Rat     1 MFAKAFRVKSNTAIKGSDRRKLRADVTVAFPTLGTDQVSELIPGKEELNVVKLYAHKGDAVTVYT 65

  Fly    63 VDKLPLFFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVGLSMYGH 127
            ....|:.|||: ..|.||:||||..||:||.|.|...||.||..||||||||||....||.   .
  Rat    66 SGGNPILFELE-KNLYPTVYTLWSHPDLLPAFITWPLVLEKLVGGADLMLPGVVVPPTGLP---Q 126

  Fly   128 FKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLWSHEPSLVQQIPLVK 192
            .::|.|.|:.|..|::.|.||..|.|:.::...|..|..|.:||.:.|.||.
  Rat   127 VQQGDLCAIALVGNRAPVAVGVAAMSTAQMLASGLKGKGISVLHTYQDHLWR------------- 178

  Fly   193 TKALSGEDFPALGSETERRKTASPATPAPVTFATVAQTEELETET--------AALTLESQEA-- 247
                ||:            |::.||      .|.:..|:..|.:.        .:|:||.:|.
  Rat   179 ----SGD------------KSSPPA------IAPLDPTDSCEEKADLGLHGNLRSLSLEGEEENG 221

  Fly   248 ----PES--------------DEEAVEEASPELILKNAFLSALKNHGKKLPLPLLTSNFY--RLY 292
                ||:              |.:.::|...|| |:..||.|||:..||..||||||...  .::
  Rat   222 QVPNPEASDDPNSRALSQDSVDGKPLQEQMDEL-LEQCFLHALKSRVKKADLPLLTSTLLGSHMF 285

  Fly   293 VVTEATEQIDLKKTRYKKLSNFLAEMVDQGFIVVREESKGVDKITSVDLEHPEVVNFIT---DVK 354
            ......:|:|:||:.|||||.||..|..:..:.|:|.||||:.|.:||..||.:.:||.   .:.
  Rat   286 SCCPEGQQLDIKKSSYKKLSKFLQHMQQEQIVQVKELSKGVESIVAVDWRHPRITSFIVPEPSLA 350

  Fly   355 ASEANGAASETPLFHSELKEMYIVTDVTAAFFTKLNYKRGEGIPAGQIKKIVREYVSKHGLLHPL 419
            :......:.|.|....::|.:|.|.......|.:..:|:|..:...::::|:.:|..::.|:...
  Rat   351 SQTVQEGSREKPYLPPDIKSLYCVPANMTQLFLESGHKKGSTLEGSEVRRIITDYAKRNNLVDAD 415

  Fly   420 TK-LVRPD----DTLIELYGNREVSLSEMCSLIT---SKMEHSYQMC-SGKD---TSGK--PLIQ 470
            .: ||:.|    |.::|......|......||:|   ..::.:||:. .|::   ..||  | |.
  Rat   416 NRNLVKLDPILCDCILEKNEQHLVMKLPWDSLLTRCLKNLQPAYQVTFPGQEPIIKKGKLCP-ID 479

  Fly   471 MSLATRSGNKKVTLVSNIEAYGIILAEFIKLCKQGAAASTSVVKLPHQKHE-QLQIQGNQVRFVH 534
            ::|..::.|||||:|.|:|.||:.......:.:|...|||.|...|..|.. |:|:||||:..:.
  Rat   480 ITLVLKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKDSLQVQVQGNQIHHLG 544

  Fly   535 TLLTETYKVPPKCILGLELA-KDGKK 559
            .||.|.|::|.|.|.|||.| |.|||
  Rat   545 QLLLEEYRLPGKYIQGLEKAPKPGKK 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	Pre-PUA	2..88	CDD:436077	38/88 (43%)
		PUA_eIF2d-like	90..174	CDD:409298	35/83 (42%)
		eIF2D_C	469..551	CDD:211321	32/82 (39%)
Eif2d	NP_001017489.1	eIF2D_N	6..81	CDD:211423	30/75 (40%)
		PUA_eIF2d-like	92..173	CDD:409298	35/83 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	178..200		8/56 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..243		4/27 (15%)
		eIF2D_C	477..561	CDD:211321	33/84 (39%)