DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2D and mcts1

DIOPT Version :9

Sequence 1:	NP_477481.1	Gene:	eIF2D / 64874	FlyBaseID:	FBgn0041588	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001006880.1	Gene:	mcts1 / 448679	XenbaseID:	XB-GENE-998581	Length:	181	Species:	Xenopus tropicalis

Alignment Length:	190	Identity:	50/190 - (26%)
Similarity:	83/190 - (43%)	Gaps:	27/190 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLKPYRPKSSAA----LKGSDSKKFRQRVEAAFPHVS--VDQLVPAKAAV------TQVKILTH 53
            || |.:..|.:.:    ||.|..|..:.::...||.:.  ::|::|.|..|      ..::|||.
Frog     1 MF-KKFDEKENVSNCIQLKTSVIKGIKNQLIDQFPVIEQWLNQIMPKKDPVKIVRCHEHIEILTV 64

  Fly    54 GGVQSMVYCVDKLPLFFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPL 118
            .|..          |||....|...|||..|...|.|||:....:|.:..:.:||::|.||:...
Frog    65 NGEL----------LFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSP 119

  Fly   119 GVGLSMYGHFKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLW 178
            |..|....   ...::|:.....:.|:.||.:..|:|::... ..|:.|:.:|...|.||
Frog   120 GAKLYPAA---ADTVVAIMAEGKQHALCVGVMKMSADDIEKV-NKGIGIENIHYLNDGLW 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	19/84 (23%)
		Tma20	9..178	CDD:224927	45/180 (25%)
		PUA	61..175	CDD:294405	29/113 (26%)
		eIF2D_C	469..551	CDD:211321
mcts1	NP_001006880.1	MCT1_N	4..80	CDD:211422	19/85 (22%)
mcts1	NP_001006880.1	Tma20	23..177	CDD:224927	43/167 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910