DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF2D and eif2d

DIOPT Version :9

Sequence 1:	NP_477481.1	Gene:	eIF2D / 64874	FlyBaseID:	FBgn0041588	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_989398.1	Gene:	eif2d / 395035	XenbaseID:	XB-GENE-947279	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	606	Identity:	199/606 - (32%)
Similarity:	309/606 - (50%)	Gaps:	66/606 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLKPYRPKSSAALKGSDSKKFRQRVEAAFPHVSVD---QLVPAKAAVTQVKILTHGGVQSMVYC 62
            ||.|.:|.||:.|:||||.:|.|..:.:|||.::.:   :|:|:|..::.||:..|.|....:|.
Frog     1 MFAKNFRVKSNTAIKGSDRRKLRADISSAFPFLTTENLSELMPSKEELSIVKVFAHKGDAVTLYV 65

  Fly    63 VDKLPLFFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVGLSMYGH 127
            .::.|:.|||: ..|.||:|.||..||:||.|||...||.|:..||||||||||....||.   .
Frog    66 HNRNPVMFELE-KNLYPTVYALWKYPDLLPAFTTWPPVLEKMAGGADLMLPGVVVPSFGLP---E 126

  Fly   128 FKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLWSH-EPSLVQQIPL- 190
            .::|.|.|:.|..|::.|.||....||.|:...|..|....:||.|||:||:: :.|.:..||:
Frog   127 IQQGSLCAITLVGNRAPVAVGVATMSSKEMLASGMKGKGFNILHTFGDQLWAYGDKSCLPNIPIP 191

  Fly   191 -VKTKALSGEDFPALGSETERRKTASPATPAPVTFATVAQTEEL---ETETAALTLESQEAPESD 251
             |....:...|..|:..|.    ::....|.       ||.|.|   |.||.....:|::..|..
Frog   192 EVSLTVVEEGDGQAVSQEV----SSEAQDPQ-------AQLENLNLMEEETTHKEEDSEKHCEGV 245

  Fly   252 EEAVEEA------------SPELILKNAFLSALKNHGKKLPLPLLTSNFYRLYVVTEATE--QID 302
            :|.::|.            :.:.:|...|..|||:..||..||||||.|.|.|:.....|  |:|
Frog   246 DEQIKETENLVPLQKSSQEAMDSLLHQCFFHALKHKVKKSDLPLLTSTFLRNYLFACCPEGQQVD 310

  Fly   303 LKKTRYKKLSNFLAEMVDQGFIVVREESKGVDKITSVDLEHPEVVNFI------TDVKASEANGA 361
            :||:.||||:.||..|..:..:.|:|.:|||:.|..:|.:||:|.:|:      .|:..|.:...
Frog   311 IKKSSYKKLTKFLQTMQQRKVLQVKELNKGVESIVEIDWKHPDVRSFVAPEPVPVDLVVSGSIDG 375

  Fly   362 ASETPLFHSELKEMYIVTDVTAAFFTKLNYKRGEGIPAGQIKKIVREYVSKHGLLHPLTK---LV 423
            ..|:|....|:..:|.::......|.:..:::|:.:....::.|:..||..:.|:....|   .:
Frog   376 GGESPYQPPEIITLYGISSKMLPLFQEAGHRKGDLLTHSDVRSIIITYVKNNELVDSNNKNFVNI 440

  Fly   424 RP--DDTLIELYGNRE---VSLSEMCSLITSKMEHSYQMCSGKDTSGKP---------LIQMSLA 474
            .|  .|.|:|.....:   :...::......||:||:|:    ...|:|         .|.:|:.
Frog   441 NPVLCDCLLEKSEQNDFFSLKWDDLLLRCLEKMQHSHQV----TFPGRPPIIRKGNIDPIDISVV 501

  Fly   475 TRSGNKKVTLVSNIEAYGIILAEFIKLCKQGAAASTSVVKLPHQKHE-QLQIQGNQVRFVHTLLT 538
            .|:.|||||::.|:|.||:..:....:.:|...||::...:|..|.. |:|||||||..|..||.
Frog   502 QRASNKKVTMIKNLELYGLDPSSVGSMLQQRVQASSTCTAIPGSKDRVQVQIQGNQVSQVGKLLL 566

  Fly   539 ETYKVPPKCILGLELAKDGKK 559
            |.:|:|.|.|.||:|||.|||
Frog   567 EEFKIPRKYISGLDLAKSGKK 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	26/75 (35%)
		Tma20	9..178	CDD:224927	70/171 (41%)
		PUA	61..175	CDD:294405	49/113 (43%)
		eIF2D_C	469..551	CDD:211321	33/82 (40%)
eif2d	NP_989398.1	Pre-PUA	2..90	CDD:375366	33/88 (38%)
		Tma20	7..177	CDD:224927	71/173 (41%)
		eIF2D_C	495..579	CDD:211321	33/83 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4207
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H38244
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3103
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247905at33208
OrthoFinder	1	1.000	-	-		FOG0005549
OrthoInspector	1	1.000	-	-		oto102572
Panther	1	1.100	-	-	LDO	PTHR12217
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4504
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160