Protein Alignment eIF2D and eif2d

DIOPT Version :9

• Sequence 1: NP_477481.1
• Gene: eIF2D / 64874
• FlyBaseID: FBgn0041588
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: NP_957456.1
• Gene: eif2d / 394137
• ZFINID: ZDB-GENE-040426-1226
• Length: 590
• Species: Danio rerio
• Alignment Length: 603
• Identity: 218/603 - (36%)
• Similarity: 313/603 - (51%)
• Gaps: 58/603 - (9%)

  Fly     1 MFLKPYRPKSSAALKGSDSKKFRQRVEAAFPHVSVD---QLVPAKAAVTQVKILTHGGVQSMVYC 62
            ||.|.:|.||:..:||||.:|.|..:.||||.:||:   :|||.|..:..|||..|.|....:|.
Zfish     1 MFAKAFRVKSNTVIKGSDRRKLRADISAAFPSLSVEELNELVPNKEELNIVKIYAHKGDAVTLYV 65

  Fly    63 VDKLPLFFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVGLSMYGH 127
            :.|.|:||:|: .||.||:||||..|::||.|||...||.||:.||||||||||....||.   .
Zfish    66 LHKNPIFFQLE-KQLFPTVYTLWRCPNMLPAFTTWPPVLQKLSGGADLMLPGVVLSTSGLP---E 126

  Fly   128 FKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLW-----SHEPSLVQQ 187
            ..:|:..||.|..|::.|.||..|.||.|:...|..|..:.:||.:.|:||     :|.|    .
Zfish   127 VNRGECCAVTLVMNRAPVAVGTAAMSSAEMRNSGMKGKGVNVLHTYMDQLWAFGDKTHPP----V 187

  Fly   188 IPLVKTKA-LSGEDFPALGSETERRKTASPATPAPVTFATVAQT-EELE-TETAALTLESQE--- 246
            ||:..:.. :.||:   .|.|.|..:.....:...|...|..|: :||: .|...|..||.|
Zfish   188 IPVTNSPTQVEGEE---EGEECEEEEEEVKDSSENVAVETSCQSLQELKLAENEVLKEESVEDKE 249

  Fly   247 -----APESDEEAVEEASPELILKNAFLSALKNHGKKLPLPLLTSNFYRLYVVT--EATEQIDLK 304
                 ..|.|..:.:|...||:|: .||.|||...||..||||||.|.|.::|:  ...:|:|:|
Zfish   250 GENIDGEEGDSRSPQEQMDELLLQ-CFLHALKTKVKKSELPLLTSTFLRNHMVSCCPRGKQLDIK 313

  Fly   305 KTRYKKLSNFLAEMV-DQGFIVVREESKGVDKITSVDLEHPEVVNF------ITDVKASEANGAA 362
            |:.|||||.||..|. |.....|:|.||||:.|..||..:||:.:|      ..:.:..|.:||.
Zfish   314 KSSYKKLSKFLQIMQRDHSLPQVKELSKGVESIVDVDWRNPELCSFKIPEDCALEKEFEEGDGAC 378

  Fly   363 SETPLFHSELKEMYIVTDVTAAFFTKLNYKRGEGIPAGQIKKIVREYVSKHGLLHPLTK---LVR 424
             |......|:..:|.||......|...:.|:|..:.|.:::..:.|||.|:.|::.:.|   ::.
Zfish   379 -EVEYQPPEITPLYGVTARLEPLFQDAHKKKGTSLKATEVRNTITEYVKKNELVNEINKNYVIIN 442

  Fly   425 PD--DTLIELYGNREVSLSEMCSLITSKMEHSYQMCSGKDTSGKP---------LIQMSLATRSG 478
            |.  |.|:|....:||.:.:...|| |:.....|.|......|:|         .|.:|:|:|..
Zfish   443 PTLCDCLLEKSEYQEVEMLKWDDLI-SRTLIRMQACHEVLFPGQPPVVKKGQMEPIDISVASRGS 506

  Fly   479 NKKVTLVSNIEAYGIILAEFIKLCKQGAAASTSVVKLPHQKHEQL-QIQGNQVRFVHTLLTETYK 542
            |||||::.|:||:|:..|...:..:....||..:...|..|:..| |||||||:.|..||.:.|:
Zfish   507 NKKVTVIKNLEAFGLDPATVAEALQHQVQASCVLHDCPGAKNRVLVQIQGNQVQHVGKLLLDRYQ 571

  Fly   543 VPPKCILGLELA-KDGKK 559
            :|.|.:.||:.| |.|||
Zfish   572 IPRKYVQGLDKAPKPGKK 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	32/75 (43%)
		Tma20	9..178	CDD:224927	76/171 (44%)
		PUA	61..175	CDD:294405	52/113 (46%)
		eIF2D_C	469..551	CDD:211321	32/82 (39%)
eif2d	NP_957456.1	eIF2D_N	6..81	CDD:211423	32/75 (43%)
		Tma20	19..179	CDD:224927	72/163 (44%)
		PUA	64..170	CDD:294405	50/109 (46%)
		eIF2D_C	496..580	CDD:211321	32/83 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587092
Domainoid	1	1.000	103	1.000	Domainoid score	I6751
eggNOG	1	0.900	-	-		E1_COG2016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38244
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2889
OMA	1	1.010	-	-		QHG55541
OrthoDB	1	1.010	-	-		D247905at33208
OrthoFinder	1	1.000	-	-		FOG0005549
OrthoInspector	1	1.000	-	-		oto38676
orthoMCL	1	0.900	-	-		OOG6_102936
Panther	1	1.100	-	-	LDO	PTHR12217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3687
SonicParanoid	1	1.000	-	-		X4504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800