Protein Alignment eIF2D and EIF2D

DIOPT Version :9

• Sequence 1: NP_477481.1
• Gene: eIF2D / 64874
• FlyBaseID: FBgn0041588
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: NP_008824.2
• Gene: EIF2D / 1939
• HGNCID: 6583
• Length: 584
• Species: Homo sapiens
• Alignment Length: 618
• Identity: 221/618 - (35%)
• Similarity: 305/618 - (49%)
• Gaps: 94/618 - (15%)

  Fly     1 MFLKPYRPKSSAALKGSDSKKFRQRVEAAFPHVSVDQ---LVPAKAAVTQVKILTHGGVQSMVYC 62
            ||.|.:|.||:.|:||||.:|.|..|..|||.:..||   |||.|..:..||:..|.|....||.
Human     1 MFAKAFRVKSNTAIKGSDRRKLRADVTTAFPTLGTDQVSELVPGKEELNIVKLYAHKGDAVTVYV 65

  Fly    63 VDKLPLFFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVGLSMYGH 127
            ....|:.|||: ..|.||:||||..||:||.|||...||.||..||||||||:|....||.   .
Human    66 SGGNPILFELE-KNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVMPPAGLP---Q 126

  Fly   128 FKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLW-----SHEPSLVQQ 187
            .:||.|.|::|..|::.|.:|..|.|:.|:...|..|....:||.:.|.||     |..||:.
Human   127 VQKGDLCAISLVGNRAPVAIGVAAMSTAEMLTSGLKGRGFSVLHTYQDHLWRSGNKSSPPSIA-- 189

  Fly   188 IPLVKTKALSGEDFPALGSETERRKTASPATPAPVTFATVAQTEELETETAALTLESQ------- 245
             ||    ||...|.    ||.:               .:|.....|:.:...:|||.:
Human   190 -PL----ALDSADL----SEEK---------------GSVQMDSTLQGDMRHMTLEGEEENGEVH 230

  Fly   246 ---------EAPE-----------SDEEAVEEASPELILKNAFLSALKNHGKKLPLPLLTSNFYR 290
                     ||||           :|.:.::|...|| |:..||.|||...||..||||||.|..
Human   231 QAREDKSLSEAPEDTSTRGLNQDSTDSKTLQEQMDEL-LQQCFLHALKCRVKKADLPLLTSTFLG 294

  Fly   291 LYVVTEATE--QIDLKKTRYKKLSNFLAEMVDQGFIVVREESKGVDKITSVDLEHPEVVNFI--- 350
            .::.:...|  |:|:||:.|||||.||.:|..:..|.|:|.||||:.|.:||.:||.:.:|:
Human   295 SHMFSCCPEGRQLDIKKSSYKKLSKFLQQMQQEQIIQVKELSKGVESIVAVDWKHPRITSFVIPE 359

  Fly   351 ---TDVKASEANGAASETPLFHSELKEMYIVTDVTAAFFTKLNYKRGEGIPAGQIKKIVREYVSK 412
               |.....|   .:.|.|....::|.:|.|.......|.:..:|:|..:...:::.||..|..|
Human   360 PSPTSQTIQE---GSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSFLEGSEVRTIVINYAKK 421

  Fly   413 HGLLHPLTK-LVRPD----DTLIELYGNREVSLSEMCSLIT---SKMEHSYQM-CSGKDTSGK-- 466
            :.|:....| |||.|    |.::|......|......||:|   .|::.:||: ..|::...|
Human   422 NDLVDADNKNLVRLDPILCDCILEKNEQHTVMKLPWDSLLTRCLEKLQPAYQVTLPGQEPIVKKG 486

  Fly   467 ---PLIQMSLATRSGNKKVTLVSNIEAYGIILAEFIKLCKQGAAASTSVVKLPHQKHE-QLQIQG 527
               | |.::||.|:.|||||:|.|:||||:.......:.:|...|||:|...|..|.. |:||||
Human   487 RICP-IDITLAQRASNKKVTVVRNLEAYGLDPYSVAAILQQRCQASTTVNPAPGAKDSLQVQIQG 550

  Fly   528 NQVRFVHTLLTETYKVPPKCILGLELA-KDGKK 559
            |||..:..||.|.|::|.|.|.|||.| |.|||
Human   551 NQVHHLGWLLLEEYQLPRKHIQGLEKALKPGKK 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	31/75 (41%)
		Tma20	9..178	CDD:224927	74/171 (43%)
		PUA	61..175	CDD:294405	49/113 (43%)
		eIF2D_C	469..551	CDD:211321	37/82 (45%)
EIF2D	NP_008824.2	Pre-PUA	2..90	CDD:407697	39/88 (44%)
		PUA_eIF2d-like	92..173	CDD:409298	35/83 (42%)
		PUA domain	93..173		35/82 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	223..257		4/33 (12%)
		eIF2D_C	490..574	CDD:211321	38/84 (45%)
		SUI1 domain	491..564		33/72 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152610
Domainoid	1	1.000	154	1.000	Domainoid score	I4271
eggNOG	1	0.900	-	-		E1_COG2016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38244
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2937
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55541
OrthoDB	1	1.010	-	-		D247905at33208
OrthoFinder	1	1.000	-	-		FOG0005549
OrthoInspector	1	1.000	-	-		oto88705
orthoMCL	1	0.900	-	-		OOG6_102936
Panther	1	1.100	-	-	LDO	PTHR12217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3687
SonicParanoid	1	1.000	-	-		X4504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800