DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2D and C11D2.7

DIOPT Version :9

Sequence 1:	NP_477481.1	Gene:	eIF2D / 64874	FlyBaseID:	FBgn0041588	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_741412.1	Gene:	C11D2.7 / 177377	WormBaseID:	WBGene00015703	Length:	185	Species:	Caenorhabditis elegans

Alignment Length:	177	Identity:	47/177 - (26%)
Similarity:	80/177 - (45%)	Gaps:	28/177 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LKGSDSKKFRQRVEAAFPHVS--VDQLVPAKAAVTQVKILTHGGVQSMVYCVDKLPL-------- 68
            ||.|..|..|:::...||::.  :::::|.|.....:|            |.|.:.|
Worm    17 LKSSVQKGIRKKLIENFPYLEPHLEEILPKKENFKVIK------------CKDHIELLADHLGVV 69

  Fly    69 -FFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVGLSMYGHFKKGQ 132
             |.:......:|||.||...|.|||:....:|.:..:.||:.:|.||:...|..|:..  ..|..
Worm    70 RFVKTRNTDYIPTLRTLHKYPFILPHQQVDKGAIKFILNGSSIMCPGLTSPGAKLTPL--VPKDS 132

  Fly   133 LMAVNLTNNKSAVGVGQLARSSDELYMCG-GHGVAIKMLHLFGDKLW 178
            ::||.....:.|:.:|.::.||:|:.... |:|  |:.||...|.||
Worm   133 VVAVMAEGKQHALAIGLMSMSSEEIQSVNKGNG--IENLHYLNDGLW 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	14/75 (19%)
		Tma20	9..178	CDD:224927	45/175 (26%)
		PUA	61..175	CDD:294405	34/123 (28%)
		eIF2D_C	469..551	CDD:211321
C11D2.7	NP_741412.1	MCT1_N	4..81	CDD:211422	14/75 (19%)
C11D2.7	NP_741412.1	Tma20	18..177	CDD:224927	44/174 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2016
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810