Protein Alignment eIF2D and eif-2D

DIOPT Version :9

• Sequence 1: NP_477481.1
• Gene: eIF2D / 64874
• FlyBaseID: FBgn0041588
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: NP_495114.3
• Gene: eif-2D / 173964
• WormBaseID: WBGene00016113
• Length: 549
• Species: Caenorhabditis elegans
• Alignment Length: 596
• Identity: 171/596 - (28%)
• Similarity: 289/596 - (48%)
• Gaps: 84/596 - (14%)

  Fly     1 MFLKPYRPKSSAALKGSDSKKFRQRVEAAFPHVSVDQLVPAKAAVTQVKILTHGGVQSMVYCVDK 65
            ||.||:..|.:...:.|||:|...|::   ..|:.:..:..|..|.|||:.|..|.|..||.:||
 Worm     1 MFKKPFTVKKNTNQRNSDSRKLFNRLK---EEVNGESNIDKKGQVAQVKLTTFEGTQMNVYTIDK 62

  Fly    66 LPLFFEL-DGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVGLSMYGHFK 129
            :|:.||. :.|.:.||:|.:|......|....||.|...|.||||||||||:...:  ..:..|:
 Worm    63 VPMLFEFSENGNIYPTVYYMWNNQKTFPVLICHEPVFSYLENGADLMLPGVIRSSI--FPFPTFR 125

  Fly   130 KGQLMAV-------NLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLWSHEPSLVQQ 187
            ||..:|:       ...:..||||...:  ||:|:.:||..|..:::||:|.|:||...|   :.
 Worm   126 KGAPVAIAFYSSETETVSGPSAVGCSMM--SSEEMVVCGFKGKGVQVLHVFRDQLWDFGP---KG 185

  Fly   188 IPLVKTKALSGEDFPALGSETERRKTASPATPAPVTFATVAQTEE-LETETAALTLESQEAPESD 251
            :|    .:.|.||:..:|.|:|..:...             :|:| .|.:....||..:   |..
 Worm   186 VP----PSCSLEDWNKIGVESEESEEDE-------------ETDERKELDACQSTLPKE---EEK 230

  Fly   252 EEAVEEASPELILKNAFLSALKNHGKKLPLPLLTSNFYRLYVVTEATE--QIDLKKTRYKKLSNF 314
            :|.::|...|.:|...||:.||:...:..||:....||...|::...:  ::|:|||.:||.:.|
 Worm   231 QEVIQEEPMENLLTRCFLAGLKHRFTRNQLPMDVGQFYTQCVLSCVPDGRRLDMKKTHFKKFATF 295

  Fly   315 LAEM--VDQGFIV---VREESKGVDKITSVDLEHPEVVNF-ITD---VKASEANGAASETPLFHS 370
            |.|:  ::..:|:   ..:|.||.|.:..|:..:....:| :||   |..:.|..|..:.|:
 Worm   296 LQEINELESEWIIKITPSKEKKGADIVADVNFSNKLFRDFEVTDERIVDEAPAEKAKFDAPV--- 357

  Fly   371 ELKEMYIVTDVTAAFFTKLNYKRGEGIPAGQIKKIVREYVSKHGL-------LHPL----TKLVR 424
             :.|.:.:|:.|...|.  ...:|:.:...|||:.|.:||:::.|       |.|:    || ::
 Worm   358 -IAEYFAITEPTLKLFP--GCSKGDLLTVKQIKEFVTKYVNENKLAAGGSVRLDPIIFSVTK-IQ 418

  Fly   425 PDDTLIELYGNREVSLSEMCSLITSKMEHSYQM--CSGKDTSGK---PLIQMSLATRSGNKKVTL 484
            .|.|          ..:.:...|.|:|..::.:  ..|::...|   |.::..:..|:|||||||
 Worm   419 TDTT----------PWANLMKEIHSRMTATWHIRWPDGREIVRKVSPPRVEFKIENRAGNKKVTL 473

  Fly   485 VSNIEAYGIILAEFIKLCKQGAAAS-TSVVKLPHQKHEQLQIQGNQVRFVHTLLTETYKVPPKCI 548
            ::.:..:||.:.......:.|.|.| ||..::|..:..|:.:||||:.|:..||.::|.:..|.:
 Worm   474 LNGLAMFGIDIRTICHQIQTGVATSVTSQWEVPGVEGPQVLVQGNQIHFIADLLIKSYGIDKKFM 538

  Fly   549 LGLELAKDGKK 559
            .|.|||...||
 Worm   539 KGTELAVKKKK 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	23/73 (32%)
		Tma20	9..178	CDD:224927	60/176 (34%)
		PUA	61..175	CDD:294405	43/121 (36%)
		eIF2D_C	469..551	CDD:211321	26/82 (32%)
eif-2D	NP_495114.3	eIF2D_N	6..77	CDD:211423	23/73 (32%)
		Tma20	15..181	CDD:224927	61/172 (35%)
		PUA	58..176	CDD:294405	43/121 (36%)
		eIF2D_C	457..540	CDD:211321	26/82 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162551
Domainoid	1	1.000	108	1.000	Domainoid score	I4042
eggNOG	1	0.900	-	-		E1_COG2016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38244
Inparanoid	1	1.050	204	1.000	Inparanoid score	I2448
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55541
OrthoDB	1	1.010	-	-		D247905at33208
OrthoFinder	1	1.000	-	-		FOG0005549
OrthoInspector	1	1.000	-	-		oto18270
orthoMCL	1	0.900	-	-		OOG6_102936
Panther	1	1.100	-	-	LDO	PTHR12217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3687
SonicParanoid	1	1.000	-	-		X4504
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840