DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF2D and Eif2d

DIOPT Version :9

Sequence 1:	NP_477481.1	Gene:	eIF2D / 64874	FlyBaseID:	FBgn0041588	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	XP_006529228.1	Gene:	Eif2d / 16865	MGIID:	109342	Length:	587	Species:	Mus musculus

Alignment Length:	596	Identity:	193/596 - (32%)
Similarity:	287/596 - (48%)	Gaps:	90/596 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLKPYRPKSSAALKGSDSKKFRQRVEAAFPHVSVDQ---LVPAKAAVTQVKILTHGGVQSMVYC 62
            ||.|.:|.||:.|:||||.:|.|..|.||||.:..||   |:|.|..:..||:..|.|....||.
Mouse     1 MFAKAFRVKSNTAIKGSDRRKLRADVTAAFPALGTDQISELIPGKEELNVVKLYVHKGDSVTVYT 65

  Fly    63 VDKLPLFFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVGLSMYGH 127
            ....|:.|||: ..|.||:||||..|||||.|.|...||.||..||||||||||....||.   .
Mouse    66 SGGNPILFELE-KNLYPTVYTLWAYPDILPTFITWPLVLEKLVGGADLMLPGVVVPPTGLP---Q 126

  Fly   128 FKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLWSHEPSLVQQIPLVK 192
            .::|.|.|:.|..|::.|.:|..|.|:.::...|..|..:.:||.:.|.||.
Mouse   127 VQQGDLCAIALVGNRAPVAIGVAAMSTAQMLASGLKGKGVSVLHTYQDHLWR------------- 178

  Fly   193 TKALSGEDFPALGSETERRKTASPATPAPVTFATVAQTEE-----LETETAALTLESQE------ 246
                ||:             .:||...||:.  .....||     |:....:|||:.:|
Mouse   179 ----SGD-------------KSSPPAIAPLD--PTDSCEEKVHLGLQGNLKSLTLDGEEENGQVP 224

  Fly   247 -----------APESDE---EAVEEASPELILKNAFLSALKNHGKKLPLPLLTSNFY--RLYVVT 295
                       ||..|.   :.::|...:|:|: .||.|||:..||..||||||...  .::...
Mouse   225 LREASEDTSSRAPSQDSLDGKPLQEQMDDLLLR-CFLHALKSRVKKADLPLLTSTLLGSHMFSCC 288

  Fly   296 EATEQIDLKKTRYKKLSNFLAEMVDQGFIVVREESKGVDKITSVDLEHPEVVNFI---TDVKASE 357
            ...:|:|:||:.|||||.||..|..:..:.|:|.||||:.|.:||..||.:.:|:   ..:.:..
Mouse   289 PEGQQLDIKKSSYKKLSKFLQHMQQEQIVQVKELSKGVESIVAVDWRHPRITSFVIPEPSLTSQT 353

  Fly   358 ANGAASETPLFHSELKEMYIVTDVTAAFFTKLNYKRGEGIPAGQIKKIVREYVSKHGLLHPLTK- 421
            ....:.|.|....::|.:|.|.......|.:..:|:|..:...:::||:.:|..::.|:....:
Mouse   354 VQEVSREQPYLPPDIKSLYCVPANMTQLFLESGHKKGSTLEGSEVRKIITDYAKRNRLVDADNRN 418

  Fly   422 LVRPD----DTLIELYGNREVSLSEMCSLIT---SKMEHSYQMC-SGKD---TSGK--PLIQMSL 473
            ||:.|    |.::|......|:......|:|   ..|:.:||:. .|::   ..||  | |.::|
Mouse   419 LVKLDPILCDCILEKNEQHLVTKLPWDCLLTRCLKNMQPAYQVTFPGQEPILKKGKLCP-IDITL 482

  Fly   474 ATRSGNKKVTLVSNIEAYGIILAEFIKLCKQGAAASTSVVKLPHQKHE-QLQIQGNQVRFVHTLL 537
            |.::.|||||:|.|:|.||:.......:.:|...|||.|...|..|.. |:|:||||:..:..||
Mouse   483 ALKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKDSLQVQVQGNQIHHLGQLL 547

  Fly   538 ----TETYKVP 544
                |.|..:|
Mouse   548 LGENTGTLHLP 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	eIF2D_N	6..79	CDD:211423	31/75 (41%)
		Tma20	9..178	CDD:224927	73/171 (43%)
		PUA	61..175	CDD:294405	48/113 (42%)
		eIF2D_C	469..551	CDD:211321	31/81 (38%)
Eif2d	XP_006529228.1	Pre-PUA	2..90	CDD:375366	39/88 (44%)
		Tma20	7..178	CDD:224927	75/174 (43%)
		eIF2D_C	477..550	CDD:211321	29/73 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842669
Domainoid	1	1.000	143	1.000	Domainoid score	I4656
eggNOG	1	0.900	-	-		E1_COG2016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38244
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3046
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55541
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005549
OrthoInspector	1	1.000	-	-		oto92273
orthoMCL	1	0.900	-	-		OOG6_102936
Panther	1	1.100	-	-	LDO	PTHR12217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3687
SonicParanoid	1	1.000	-	-		X4504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790