Protein Alignment eIF2D and eIF2D

DIOPT Version :10

• Sequence 1: NP_477481.1
• Gene: eIF2D / 64874
• FlyBaseID: FBgn0041588
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: XP_061515733.1
• Gene: eIF2D / 1280844
• VectorBaseID: AGAMI1_000426
• Length: 593
• Species: Anopheles gambiae
• Alignment Length: 611
• Identity: 265/611 - (43%)
• Similarity: 377/611 - (61%)
• Gaps: 66/611 - (10%)

  Fly     1 MFLKPYRPKSSAALKGSDSKKFRQRVEAAFPHVSVD---------QLVPAKAAVTQVKILTHGGV 56
            ||:||::.||:..:.||:.|:.||||.|.|.....:         :|...:|.|..||::|:...
Mosquito     1 MFIKPFKIKSNILVTGSEKKRLRQRVMAQFNRPDEETGTAPSPLAELFGNRAKVCTVKLITYHEE 65

  Fly    57 QSMVYCVDKLPLFFELDGGQLVPTLYTLWIVPDILPYFTTHEGVLPKLTNGADLMLPGVVPLGVG 121
            ...||..||.|:||||: |:|:||:||||..||::|.||||..|||||.||||||:||||..|..
Mosquito    66 PVTVYTSDKRPIFFELN-GKLLPTVYTLWSCPDLVPAFTTHATVLPKLANGADLMIPGVVKKGTN 129

  Fly   122 LSMYGHFKKGQLMAVNLTNNKSAVGVGQLARSSDELYMCGGHGVAIKMLHLFGDKLWSHEPSLVQ 186
            |:.:|..:|..::|||||:|::|||||.||.||.:|||||||||.::|:|:||||||..|||:.|
Mosquito   130 LASWGRHQKDDVVAVNLTSNRAAVGVGLLAHSSSDLYMCGGHGVCVRMMHVFGDKLWGMEPSVCQ 194

  Fly   187 QIPL------VKTKALSGEDFPALGSETERRKTASPATPAPVTFATVAQTEELETETAALTLESQ 245
            |:||      |.|::    |||.||||          .|.||..|....|:.|  |.||||.:.:
Mosquito   195 QVPLHGSVVSVPTES----DFPPLGSE----------KPKPVEEAVKQVTKSL--ENAALTAQEE 243

  Fly   246 EA----------PESDEEAVEEASPELILKNAFLSALKNHGKKLPLPLLTSNFYRLYVVTEATEQ 300
            |:          |:..|||.:..:|:.::|.|.|:|||.||||:.||||||.||..||..|..:.
Mosquito   244 ESTSDGDASDDEPQEPEEAEKPPNPDELIKGALLNALKLHGKKIALPLLTSTFYPQYVQPEIPDG 308

  Fly   301 IDLKKTRYKKLSNFLAEMVDQGFIVVREESKGVDKITSVDLEHPEVVNFITDVKASEAN------ 359
            |::||:.|||:..|...|.::|.:.::||.||::|:|:::||||.|::|. ..||.:|:
Mosquito   309 IEMKKSSYKKVGTFFKRMAEEGLLEIKEEKKGIEKVTALNLEHPAVLSFY-PYKAQKASADGQDA 372

  Fly   360 --GAAS---ETPLFHSELKEMYIVTDVTAAFFTKLNYKRGEGIPAGQIKKIVREYVSKHGLLHPL 419
              |.||   ..||..:::..||.|::.||..|...|...|:.:...|::..:|:||.::.|::|.
Mosquito   373 PGGPASSGASNPLLLTQMTAMYAVSERTAKLFGCFNVALGKTLDQTQVRNYMRDYVGRNKLINPS 437

  Fly   420 TKLVRPDDTLIELYG--------NREVSLSEMCSLITSKMEHSYQMCS--GKDTSG--KPLIQMS 472
            ||||..||||.::.|        ...|.|:::...:.:.|..:::|.|  |..|.|  :.:|.::
Mosquito   438 TKLVTLDDTLRDICGCPPAPEEPEVLVGLADLTETVLNCMTSTFEMRSQKGAVTKGGKRAIIHLT 502

  Fly   473 LATRSGNKKVTLVSNIEAYGIILAEFIKLCKQGAAASTSVVKLPHQKHEQLQIQGNQVRFVHTLL 537
            .|||||||||||:||:..|||.:.:|.|..|.||||||::.::|..|.|||.:|||.::||..||
Mosquito   503 TATRSGNKKVTLISNLADYGINVNDFAKAVKLGAAASTTMTEVPGSKGEQLMVQGNHIKFVFELL 567

  Fly   538 TETYKVPPKCILGLELAKDGKKNKKK 563
            |.||:||..||.|||.||:.||.|||
Mosquito   568 TTTYQVPKACITGLEFAKEQKKKKKK 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2D	NP_477481.1	Pre-PUA	2..88	CDD:436077	37/94 (39%)
		PUA_eIF2d-like	90..174	CDD:409298	50/83 (60%)
		eIF2D_C	469..551	CDD:211321	45/81 (56%)
eIF2D	XP_061515733.1	None