Protein Alignment MESK4 and LRMDA

DIOPT Version :10

• Sequence 1: NP_525017.1
• Gene: MESK4 / 64872
• FlyBaseID: FBgn0043069
• Length: 280
• Species: Drosophila melanogaster
• Sequence 2: NP_001292510.1
• Gene: LRMDA / 83938
• HGNCID: 23405
• Length: 226
• Species: Homo sapiens
• Alignment Length: 228
• Identity: 61/228 - (26%)
• Similarity: 88/228 - (38%)
• Gaps: 54/228 - (23%)

  Fly    88 RISLAYENLKTIPRRLADKFAAQTKFLDLSHNDFRNLRFLSFFEDLDTLILDRNVNLDINTFPYL 152
            ::|...::.:.||..|........|.||||.|..|:|..||.|..|:.||||.|...|....|.|
Human    10 QVSYIGQDCREIPEHLGRDCGHFAKRLDLSFNLLRSLEGLSAFRSLEELILDNNQLGDDLVLPGL 74

  Fly   153 PSLRILWINNCDIANITDWIHRIERHCPALDQLSCMGNPGIRTVFGGQGPRE------------- 204
            |.|..|.:|...|.::.:.:..:....|||:.||.:||...        |.|
Human    75 PRLHTLTLNKNRITDLENLLDHLAEVTPALEYLSLLGNVAC--------PNELVSLEKDEEDYKR 131

  Fly   205 ---YILQVLPQLKYLDGLPTSR--------NAAYATLSSSQGQGPDSTSNSEK--PPLASAFTFK 256
               ::|..||.||:||....:|        ...:..:...:....|..|:.|:  .||.||
Human   132 YRCFVLYKLPNLKFLDAQKVTRQEREEALVRGVFMKVVKPKASSEDVASSPERHYTPLPSA---- 192

  Fly   257 DIIRPKYSRK--SHSGRM-------FGNGSSTN 280
                   ||:  ||.|.:       :|..|..|
Human   193 -------SRELTSHQGVLGKCRYVYYGKNSEGN 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MESK4	NP_525017.1	LRR	1..>190	CDD:443914	34/101 (34%)
		leucine-rich repeat	111..132	CDD:275378	11/20 (55%)
		LRR_9	<114..217	CDD:405295	38/118 (32%)
		leucine-rich repeat	133..154	CDD:275378	9/20 (45%)
		leucine-rich repeat	155..181	CDD:275378	4/25 (16%)
LRMDA	NP_001292510.1	leucine-rich repeat	34..54	CDD:275378	11/19 (58%)
		LRR_9	<36..159	CDD:405295	41/130 (32%)
		leucine-rich repeat	55..76	CDD:275378	9/20 (45%)
		leucine-rich repeat	77..103	CDD:275378	4/25 (16%)
		leucine-rich repeat	104..142	CDD:275378	9/45 (20%)