DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MESK4 and aldh3b1

DIOPT Version :9

Sequence 1:	NP_001262650.1	Gene:	MESK4 / 64872	FlyBaseID:	FBgn0043069	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_775328.2	Gene:	aldh3b1 / 282559	ZFINID:	ZDB-GENE-021120-3	Length:	473	Species:	Danio rerio

Alignment Length:	193	Identity:	35/193 - (18%)
Similarity:	58/193 - (30%)	Gaps:	80/193 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SILEDNGRISLAYENLKTIPRRLADKFAAQTKFLDLSHNDFRNLRFLSFFEDLDTLILDRNVNLD 145
            |:.|||                       :|:.|:..|.|....:|.:...::|.::.|...|
Zfish    35 SLFEDN-----------------------ETQILEALHEDLAKPKFETVLSEIDIVVNDICYN-- 74

  Fly   146 INTFPYLPSLRILWINNCDIANITDWIHRIERHCPA---------LDQLSCMGNP-GIRTVFGGQ 200
                               |:|:..|:.      |:         ||.......| |:..:.|..
Zfish    75 -------------------ISNLQTWMQ------PSYVGTNLATKLDDCFVRREPLGVVLIIGAW 114

  Fly   201 GPREYILQVLPQLKYLDGLPTSRNAAYATLSSSQGQGPDSTSNSEKPPLASAFTFKDIIRPKY 263
               .|.:|::  |..|.|...:.|.|...        |...|.:.:..||.       :.|||
Zfish   115 ---NYPIQLI--LSPLIGAIAAGNCAILK--------PSEISKATEKLLAE-------LIPKY 157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MESK4	NP_001262650.1	leucine-rich repeat	111..132	CDD:275378	5/20 (25%)
		leucine-rich repeat	133..154	CDD:275378	3/20 (15%)
		leucine-rich repeat	155..181	CDD:275378	3/25 (12%)
aldh3b1	NP_775328.2	ALDH_F3AB	5..449	CDD:143450	35/193 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900