Protein Alignment MESK4 and ALDH1A1

DIOPT Version :9

• Sequence 1: NP_001262650.1
• Gene: MESK4 / 64872
• FlyBaseID: FBgn0043069
• Length: 280
• Species: Drosophila melanogaster
• Sequence 2: NP_000680.2
• Gene: ALDH1A1 / 216
• HGNCID: 402
• Length: 501
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 42/240 - (17%)
• Similarity: 67/240 - (27%)
• Gaps: 96/240 - (40%)

  Fly    34 LESLNYEYNDVLLT---EDNVGKMITP--NPYSFSGNISISSCPSEDVSFSESILEDNGRISLAY 93
            |..|..:|..:.:.   .|:|.....|  ||.:......:.....|||..:........:|...:
Human    13 LTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77

  Fly    94 ENLKTIPR-----RLAD------------------KFAAQTKFLDLSHNDFRNLRFLSFFEDLDT 135
            ..:....|     :|||                  |..:.....||: ...:.||:.:.:.|
Human    78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLA-GCIKTLRYCAGWAD--- 138

  Fly   136 LILDRNVNLDINTFPY----------------LPSLRILWINNCDIANITDWIHRIERHCPALDQ 184
            .|..|.:.:|.|.|.|                .|.:.::|                 :..||
Human   139 KIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIW-----------------KIGPA--- 183

  Fly   185 LSCMGN---------------------------PGIRTVFGGQGP 202
            ||| ||                           ||:..:..|.||
Human   184 LSC-GNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGP 227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MESK4	NP_001262650.1	leucine-rich repeat	111..132	CDD:275378	4/20 (20%)
		leucine-rich repeat	133..154	CDD:275378	6/36 (17%)
		leucine-rich repeat	155..181	CDD:275378	1/25 (4%)
ALDH1A1	NP_000680.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	41/238 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900