Protein Alignment ISL2 and Awh

DIOPT Version :10

• Sequence 1: NP_665804.1
• Gene: ISL2 / 64843
• HGNCID: 18524
• Length: 359
• Species: Homo sapiens
• Sequence 2: NP_001261379.1
• Gene: Awh / 38451
• FlyBaseID: FBgn0013751
• Length: 287
• Species: Drosophila melanogaster
• Alignment Length: 259
• Identity: 95/259 - (36%)
• Similarity: 128/259 - (49%)
• Gaps: 39/259 - (15%)

Human    27 CVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAK 91
            |..||..|.|:|.|.|. ...|||.||:|..|...||...:||:|:.:.|||.||.:.||.||:|
  Fly     8 CAACGEPISDRFFLEVG-GCSWHAHCLRCCMCMCPLDRQQSCFIRERQVYCKADYSKNFGAKCSK 71

Human    92 CQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPR 156
            |..|.|:||.|.|||:.|:|:.||.|..|.|||..|::|:|.:..:||:|.:   ||....|:..
  Fly    72 CCRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDDRVLCKAHY---LETVEGGTTS 133

Human   157 SPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMK 221
            |.....| .|.|                   ..||.||||...|:||..|:..:..:..||....
  Fly   134 SDEGCDG-DGYH-------------------KSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQDL 178

Human   222 EQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHEN 285
            |::..:||||.||.:|||||.|.:.||          ..|:.|..::...|:     |..||.|
  Fly   179 ERIASVTGLSKRVTQVWFQNSRARQKK----------HIHAGKNKIREPEGS-----SFARHIN 227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ISL2	NP_665804.1	LIM1_Isl	27..81	CDD:188752	23/53 (43%)
		LIM2_Isl2	89..143	CDD:188855	26/53 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..191		5/39 (13%)
		HOX	191..247	CDD:197696	24/55 (44%)
		LIM-binding domain (LID). /evidence=ECO:0000250	272..301		5/14 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	326..359
Awh	NP_001261379.1	LIM1_AWH	8..61	CDD:188759	23/53 (43%)
		LIM2_AWH	69..123	CDD:188765	26/53 (49%)
		Homeodomain	149..205	CDD:459649	23/55 (42%)