Protein Alignment ISL2 and Lim3

DIOPT Version :10

• Sequence 1: NP_665804.1
• Gene: ISL2 / 64843
• HGNCID: 18524
• Length: 359
• Species: Homo sapiens
• Sequence 2: NP_001260559.1
• Gene: Lim3 / 35184
• FlyBaseID: FBgn0002023
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 347
• Identity: 119/347 - (34%)
• Similarity: 169/347 - (48%)
• Gaps: 80/347 - (23%)

Human    27 CVGCGSQIHDQFILRVSPDLE--WHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKC 89
            |.||...|.|:|||:|   ||  |||.||:|:||...|::  .||.|:|:.:||.|:.:.:|.||
  Fly   122 CGGCHELILDRFILKV---LERTWHAKCLQCSECHGQLND--KCFARNGQLFCKEDFFKRYGTKC 181

Human    90 AKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLRE-HELLCRADHGLLLERAAAG 153
            :.|.:|...:.:|.||:|:|||::||.|::|||.|..||||.|.| .:|:|:.|:    |.|.
  Fly   182 SACDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDY----EEAK-- 240

Human   154 SPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDA 218
                      |:||:|..:..|.||..||            ||.:..|||.||:|.|..:|:|..
  Fly   241 ----------AKGLYLDGSLDGDQPNKRP------------RTTITAKQLETLKTAYNNSPKPAR 283

Human   219 LMKEQLVEMTGLSPRVIRVWFQNKRCKDK--KKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPI 281
            .::|||.:.|||..||::|||||:|.|:|  ||.....:..|...|.|.:....|.
  Fly   284 HVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKKDAGRTRWSQYFRSMKGNCSPRTD--------- 339

Human   282 RHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESG-SLGNSSGSDVTSL---- 341
                                |.|.:..|:.|.|..:...|.:.|.|. :||...|:...|:
  Fly   340 --------------------KFLDKDELKVDYDSFSHHDLSNDSYSTVNLGLDEGASPHSIRGSY 384

Human   342 ------SSQLPDTPNSMVPSPV 357
                  .||.|  |:|..|.||
  Fly   385 MHGSSSPSQYP--PSSRSPPPV 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ISL2	NP_665804.1	LIM1_Isl	27..81	CDD:188752	26/55 (47%)
		LIM2_Isl2	89..143	CDD:188855	25/54 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..191		9/39 (23%)
		HOX	191..247	CDD:197696	26/55 (47%)
		LIM-binding domain (LID). /evidence=ECO:0000250	272..301		0/28 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	326..359		13/43 (30%)
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	26/55 (47%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	25/54 (46%)
		Homeodomain	257..313	CDD:459649	28/67 (42%)