DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svep1 and Cubn

DIOPT Version :9

Sequence 1:	NP_073725.2	Gene:	Svep1 / 64817	MGIID:	1928849	Length:	3567	Species:	Mus musculus
Sequence 2:	NP_727348.2	Gene:	Cubn / 326235	FlyBaseID:	FBgn0052702	Length:	3750	Species:	Drosophila melanogaster

Alignment Length:	2344	Identity:	444/2344 - (18%)
Similarity:	668/2344 - (28%)	Gaps:	1003/2344 - (42%)

- Green bases have known domain annotations that are detailed below.

Mouse  1194 HECFLNPCHNSGTCQQLGRGYVCLCPPGYTGLKCETDIDEC-----SSLPCLNGGICRDQVGGFT 1253
            :.|...||.|.|||.....|:.|.|...:.|.|||.|::||     :.|.|.|||.|::..|.::
  Fly   156 NSCASGPCENGGTCYNTYTGFRCQCRSAFEGTKCEMDVNECALYEGTDLGCQNGGQCQNHFGTYS 220

Mouse  1254 CECSLGYSGQICEENINECISSPC---LNKGTCTDGL--ASYRCTCVKGYM-------------- 1299
            |.|..|:.|..|.:...:|..|..   ...|:|....  |.|||.|..|:.
  Fly   221 CLCQPGWHGMHCTQRKADCSQSSAWELCGHGSCVPSADDAGYRCICEPGWKTNGLTPICGEDVDE 285

Mouse  1300 ---------------------------------GVHCETDVNECQ-------------------- 1311
                                             ||.|. |::|||
  Fly   286 CSDSAAHKPCSTSCINLPGSFTCAPCPAGLTGNGVSCR-DLDECQTNNGGCSLSPKVDCINTYGS 349

Mouse  1312 --------------------------------------SSPCLNNAVCKDQVGGFSCKCPPGFLG 1338
                                                  ::||...|.|....|..||:||.|.:|
  Fly   350 YHCGECPVGWTGDGRKCERSPQDIDIPAGQTPRTCPAGNNPCYPTASCFLISGTTSCRCPMGMVG 414

Mouse  1339 TRCEKN------VDECLSQPCQNGATCK-DGANSFRCQCPAGFTGTHCELNINECQSNPCRNQAT 1396
            |....|      ...|...||.||..|. .|.:::.|.||.||....||...:.|..:||:|...
  Fly   415 TGYGPNGCVNGTTTNCKENPCLNGGICLFAGPSNYTCLCPIGFRPPICEPQPSPCDQHPCKNGGR 479

Mouse  1397 CVDELNS--YSCKCQPGFSGHRCET---------EQPSGFNLDFEVSGIYGYVLLDGVLPTLHAI 1450
            |....:.  :.|:|.||:.|..|||         ...|| .|.:...|. ||.         |..
  Fly   480 CRPTTSGDLFVCQCLPGYRGRLCETRFSSCNGMLSAQSG-RLRYPPEGT-GYE---------HNA 533

Mouse  1451 TCAFWMKSSD--VINYGTPISYALEDDKDNTFLLTDYNGWVLYVNGKEKITNCPSVNDGIWHHIA 1513
            .||:.:::::  |:|. |..|:.:||..:..|      .|:             .:|||
  Fly   534 QCAWVIRTNESLVVNV-TFNSFDVEDSTECRF------DWL-------------QINDG------ 572

Mouse  1514 ITWTSTGGAWRVYIDGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFNPAESFVGSISQLNL 1578
                 ...|.::          .|...|..:|.||                   :.|.|.:||.|
  Fly   573 -----RSAAAQI----------IGRYCGNHLPHGG-------------------NIVSSGNQLYL 603

Mouse  1579 WDYVLSPQQVKLLASSCPEELSRGNVLAWPDFLSGITGKVKVDSSSMFCSDCPSLEGSVPHLRPA 1643
            |            ..|.......|..|.|........|::..::.....|
  Fly   604 W------------FRSDNSTAKEGFDLTWNSMEPQCGGRLNFETHGTLAS--------------- 641

Mouse  1644 SGNRKPGSKVSLFCDPGFQMVGNPVQYCLNQG-QWTQPLPHCERIRCGLPPALENGFYSAE-DFH 1706
                 |||               |..|..|:. :|....|..:||:.        .|:|.: :.|
  Fly   642 -----PGS---------------PGNYPKNRDCRWQLVAPTTKRIKL--------TFFSLQLEQH 678

Mouse  1707 AGSTVTYQCTSGYYLLGDS------RMFCTDNGSWNGISPSCL---DVDECAVGSDC--SEHASC 1760
            |      .|...|.|:.||      ..:||.......:.|:.|   .....|.|||.  ..|.|.
  Fly   679 A------NCNFDYVLIKDSISGRELAKYCTTGAPAPLLLPTHLAEIHFHSDAEGSDTGFQLHYSV 737

Mouse  1761 LNTNGSYVCSCNPPYTGDGKNCAEPVKCKAPENPENGHSSGEIYTVGTAVTFSCDEGHELV---- 1821
                ...|..|...||......:|    .:..|.|.|..|.| |.:..||      |.::|
  Fly   738 ----EERVPGCGGVYTAKEGTISE----SSTANTEPGGVSCE-YEIHLAV------GEQVVIQFA 787

Mouse  1822 --GVSTITCLE-----------------------------TGEWDRLRPSCEA----------IS 1845
              .:..:.|||                             |.|::||:....|          ::
  Fly   788 RLELDPLDCLEVLDITDEGGSILQEKICGSDASRLNPPTFTSEFNRLKIKFYARAGSFQLNYRMA 852

Mouse  1846 CGVPPVPENGGVDGSAFTYGSKVVYRCDK--GYTLS----------------------GDEESAC 1886
            |......|.|.:...    |...:.|.|:  .||:|                      .|:...|
  Fly   853 CDYKLNNEQGTITSP----GYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDDDNDEC 913

Mouse  1887 LASGSWSHS-------SPVCELVKCSQPED--INNGKYILSGLTYLSIASYSCENGYSLQGPSLL 1942
            |.:....:.       .|.|..   :|||:  ::...|:   ..:||....|...|:..:..:|.
  Fly   914 LTTNLRINDGLNRKILGPYCGK---NQPEENFVSETNYL---QLHLSTDVDSMGRGFKFEYRALA 972

Mouse  1943 ----EC----TASGSWDRAP---------PSCQLVSCGEPPIVKDAVITGSNFTFGNTV--AYTC 1988
                :|    |.||...|.|         .:|..|...  |..|...:..::|:..|.|  .|..
  Fly   973 TGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMA--PANKAIRLHWNSFSLENAVDCIYDY 1035

Mouse  1989 KEGYTLAGPDTIVCQANGKWNSSNHQCLAVSCDEPPNVDHASPETAHRLFGDTAFYYCADGYSLA 2053
            .|.|     |::..|.|                     |..|...|.         ||
  Fly  1036 LEIY-----DSLGAQVN---------------------DERSKPLAK---------YC------- 1058

Mouse  2054 DNSQLICNAQGNWVPPAGQAVPRCIAHFCEKPPSVSYS---ILESVSKAKFAAGSVVSFKCMEGF 2115
                             |.:||..:         :|:|   :|:.||....:.|         ||
  Fly  1059 -----------------GNSVPEDL---------LSHSRQLVLKFVSDYSESDG---------GF 1088

Mouse  2116 VLNTSAKIECLRGGEWSPSPLSVQCIPVRCGEPPSIANGYPSGTNYSFGAVVAYSCHKGFYIKGE 2180
            .|..:.:.....||.          |....||..|  ..||:  |||.|.
  Fly  1089 DLTYTFEDRAKCGGH----------IHASSGELTS--PEYPA--NYSAGL--------------- 1124

Mouse  2181 KKSTCEATGQWSKPTPTCHPVSCNEPPKVENGFLEHTTGRTFESEARFQCNPGYKAAGSPVFVCQ 2245
               .|:    |.......|.:..    :|||          ||.|....|:..|         .:
  Fly  1125 ---DCD----WHLTGTIDHLLEI----QVEN----------FELEQSPNCSADY---------LE 1159

Mouse  2246 ANRHWHSDAPLSCTPLNCGKPPPIQNGFLKGESFEV------GSKVQFVCNEGYELVGDNSWTCQ 2304
            ......:|:||  ....||:..|.:   :.|.|.|:      .|.:.   ..|:.|
  Fly  1160 VRNGGGTDSPL--IGRFCGRDIPAR---IPGFSHEMRLILHTDSAIN---GRGFRL--------- 1207

Mouse  2305 KSGKWSKKPSPKCVPTKCAEPPLLENQLVLKELASEVGVMTISCKEGHALQGPSVLKCLPSGQWN 2369
               :|.                                :....|  |.:|:  |.:..:.|.::.
  Fly  1208 ---RWR--------------------------------IFAFGC--GGSLR--SNMGAISSPRYP 1233

Mouse  2370 GSFPICKMVLCPSPPLIPFGVPASSGALHFGSTVKYLCVDGFFLRGSPTILCQADSTWSSPLPEC 2434
            .|:|  .|..|      .:.:     :||.||.:..|..|
  Fly  1234 NSYP--NMAHC------EWRI-----SLHPGSGISLLIED------------------------- 1260

Mouse  2435 VPVECPQPEEILNGIIHVQGLA---YLSTTLYTCKPGFELVGNATTLCGENGQWLGGKPMCKPIE 2496
                           :.::||:   |.|..:||   |.:|...:.  |         |.:||..:
  Fly  1261 ---------------LELEGLSNCYYDSVKIYT---GIKLPNQSP--C---------KVLCKDDD 1296

Mouse  2497 CPEPKEILNGQFSSVSFQYGQTITYFCDRGFRLEGPKSLTCLETGDWDMDPPSCDAIHCSDPQPI 2561
            ...|...|.....::.|....:.|:   ||||:                   |..| :|......
  Fly  1297 LHNPLIQLENNKGTIVFDSDASNTF---RGFRI-------------------SYKA-NCIRNLTA 1338

Mouse  2562 ENGFVEGADYRYGAMIIYSCFPGFQVLGHAMQTCEESGWSSSSPTCVPIDCGLPPHIDFGDCTKV 2626
            ..|.:|..:|.                        |..|.:     :||:|.          ..:
  Fly  1339 TTGTIESLNYM------------------------EPFWET-----IPINCS----------WTI 1364

Mouse  2627 RDGQGHFDQEDDMMEVPYLA-HPQHLE-------------------ATAKALENTKE--SPASHA 2669
            |..:|:    ..::||.:|| |.||:.                   .|.:|:..:.|  :...:|
  Fly  1365 RAPKGN----RVLVEVSHLARHEQHVPTATMPGGLYIVDGRNVQEIVTPQAMNISGEVLTVVHNA 1425

Mouse  2670 SHF--------------LYGTMVSYSCEPGYELLGIPVLIC------QEDGTWNGT--------A 2706
            |:.              |.||. .:...|.|..:....|.|      ::|.....|        :
  Fly  1426 SNVNFQLDYRIDGCMEELRGTF-GFFQSPNYPKMYPNNLECYWLITVEQDSAIELTINNIDLEDS 1489

Mouse  2707 PSCISIECDLPVAPENGFLHFTQTTMGSAAQ-YSCKPGHILEGSHLRLCLQNKQ----WSGTVPR 2766
            |:|  .:..|.|:.....:...:...||..: .....||.|   |:|....|..    :..|...
  Fly  1490 PNC--TKDALTVSNHKNSVEVHERHCGSTTKLVITSSGHRL---HVRFISDNSHNGLGFEATYRT 1549

Mouse  2767 CEAISCSKPNPLWNGSIKGDDYSYLGVLYYEC---------------------DSGYILNGSKKR 2810
            .:| :|.......||.|:..:|......:..|                     :|||..|
  Fly  1550 VKA-TCGGKLTARNGVIESPNYPLNYPAHSRCEWQVEVSQHHQIVFEMADLNLESGYDCN----- 1608

Mouse  2811 TCQENRDWDGHEPMCIPVDCGSPPVPTNG----RVKGEEYTFQKEITYS--------------CR 2857
                   ||..|...:..|      .|.|    :|.|:|....|.::.|              .:
  Fly  1609 -------WDYLEAYDLTED------DTEGERLFKVCGDETEDDKLLSSSSNMAVVRFISDDSVSK 1660

Mouse  2858 EGFIL------------------------EGARSRICLTNGSWSGA----------TPSCMPVRC 2888
            :||.|                        :.||:..||    |...          ||:.:.:|.
  Fly  1661 KGFRLHFHESCGQTIIVDETMFDYIQMSRQAARNESCL----WVFQAVEPNKRIIFTPTHVKLRE 1721

Mouse  2889 PAPPQVPNGVADGLDYGFKKEVAFHCLEGYVLQGAPRLT-CQ-------SNGTWDAEVPVCKPAT 2945
            .|..|.|. ..|.|:.|.|      ..||...||.|||. |:       |||         :..|
  Fly  1722 DANQQYPT-EGDCLNVGVK------IYEGTEPQGTPRLKFCRSHPPALISNG---------QALT 1770

Mouse  2946 CGPPADLPQGFPNGFSFYHGGHIQ---------YQCFTG------YKLHGNPSRRCLPNGSW--- 2992
            ...|..|.:.|.        ||..         |...:|      |.....|:..||    |
  Fly  1771 VSVPLQLVEEFQ--------GHYMTMDTSCGSIYNALSGKFTSPYYPASYPPNIECL----WLLE 1823

Mouse  2993 --SGSSPSCLPCRCSTPIIQQGTINATDL----GCGK---TVQIECFKGFKLLGLSEITCDANGQ 3048
              .|:|.|.             |:.:.||    .|.:   .|:.|...| :|:|:
  Fly  1824 ASMGNSLSL-------------TLESMDLEKSESCNRDYLEVREESESG-QLIGV---------- 1864

Mouse  3049 WSDVPLCEHAQCGPLPTIPNAIVLEGSL-----SEDNVVTYSCRPGYTMQGSSDLICTEKAIWSQ 3108
                      .||  ..:|..|...|::     |:|:.|.......|..:..::|..||..|.|.
  Fly  1865 ----------YCG--NEVPGVIHSRGAIWMKFKSDDDNVGEGFMASYNYEHHNELNGTEGTIESP 1917

Mouse  3109 PYPT 3112
            .:|:
  Fly  1918 HFPS 1921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svep1	NP_073725.2	VWA	85..259	CDD:278519
		GCC2_GCC3	311..361	CDD:285001
		CCP	379..435	CDD:153056
		CCP	439..495	CDD:153056
		CCP	<514..556	CDD:153056
		HYR	560..642	CDD:280629
		DUF5011	643..722	CDD:295940
		GCC2_GCC3	1004..1051	CDD:285001
		GCC2_GCC3	1058..1105	CDD:285001
		GCC2_GCC3	1112..1159	CDD:285001
		EGF_CA	1195..1228	CDD:238011	12/32 (38%)
		EGF_CA	1230..1266	CDD:238011	14/40 (35%)
		EGF_CA	1268..1304	CDD:238011	12/87 (14%)
		EGF_CA	1306..1342	CDD:238011	16/93 (17%)
		EGF_CA	1344..1380	CDD:238011	13/42 (31%)
		EGF_CA	1382..1418	CDD:238011	10/37 (27%)
		PTX	1423..1621	CDD:238086	37/199 (19%)
		Sushi	1627..1684	CDD:278512	9/57 (16%)
		CCP	1689..1742	CDD:214478	12/59 (20%)
		EGF_CA	1744..1782	CDD:214542	10/39 (26%)
		CCP	1788..1842	CDD:153056	17/88 (19%)
		CCP	1846..1900	CDD:153056	13/84 (15%)
		CCP	1904..1958	CDD:153056	15/72 (21%)
		PHA02927	1957..2198	CDD:222943	44/245 (18%)
		CCP	1962..2015	CDD:153056	11/54 (20%)
		Sushi	2020..2077	CDD:278512	8/56 (14%)
		CCP	2082..2135	CDD:153056	11/55 (20%)
		CCP	2145..2198	CDD:153056	11/52 (21%)
		CCP	2203..2258	CDD:153056	11/54 (20%)
		CCP	2263..2318	CDD:153056	10/60 (17%)
		CCP	2322..2376	CDD:153056	7/53 (13%)
		CCP	2380..2435	CDD:153056	7/54 (13%)
		Sushi	2439..2492	CDD:278512	10/55 (18%)
		CCP	2497..2550	CDD:153056	8/52 (15%)
		CCP	2555..2607	CDD:214478	6/51 (12%)
		CCP	<2670..2710	CDD:153056	11/67 (16%)
		PHA02927	2709..2941	CDD:222943	63/317 (20%)
		CCP	2714..2768	CDD:153056	11/58 (19%)
		CCP	2772..2826	CDD:153056	13/74 (18%)
		CCP	2830..2883	CDD:153056	17/104 (16%)
		CCP	2888..2942	CDD:153056	18/61 (30%)
		CCP	2946..2999	CDD:153056	14/72 (19%)
		CCP	<3022..3056	CDD:153056	5/36 (14%)
		CCP	3060..3114	CDD:153056	15/58 (26%)
		CCP	3118..3172	CDD:153056
		Sushi	3177..3227	CDD:278512
		PHA02927	3232..3464	CDD:222943
		CCP	3237..3291	CDD:153056
		CCP	3295..3348	CDD:214478
		Sushi	3353..3407	CDD:278512
		CCP	3412..3464	CDD:214478
Cubn	NP_727348.2	EGF_CA	156..190	CDD:238011	12/33 (36%)
		EGF_CA	192..233	CDD:238011	14/40 (35%)
		EGF_CA	282..322	CDD:214542	2/39 (5%)
		EGF_3	328..366	CDD:289699	2/37 (5%)
		EGF	430..457	CDD:278437	10/26 (38%)
		EGF_CA	469..503	CDD:238011	10/33 (30%)
		CUB	509..622	CDD:238001	36/195 (18%)
		CUB	627..737	CDD:238001	30/158 (19%)
		CUB	744..849	CDD:294042	22/115 (19%)
		CUB	853..970	CDD:238001	22/126 (17%)
		CUB	978..1094	CDD:238001	36/194 (19%)
		CUB	1100..1211	CDD:238001	36/221 (16%)
		CUB	1216..1330	CDD:238001	36/206 (17%)
		CUB	1446..1549	CDD:238001	20/108 (19%)
		CUB	1554..1667	CDD:238001	24/130 (18%)
		CUB	1792..1899	CDD:238001	27/146 (18%)
		CUB	1910..1998	CDD:294042	5/12 (42%)
		CUB	2019..2133	CDD:238001
		CUB	2140..2242	CDD:238001
		CUB	2263..2379	CDD:238001
		CUB	2385..2511	CDD:238001
		CUB	2516..2630	CDD:238001
		CUB	<2833..2892	CDD:294042
		CUB	2898..3008	CDD:238001
		CUB	3011..3127	CDD:238001
		CUB	3130..3241	CDD:238001
		CUB	3254..3363	CDD:238001
		CUB	3379..3508	CDD:238001
		CUB	3531..3601	CDD:294042
		CUB	3623..3733	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000