Protein Alignment NMNAT1 and Nmnat

DIOPT Version :10

• Sequence 1: NP_073624.2
• Gene: NMNAT1 / 64802
• HGNCID: 17877
• Length: 279
• Species: Homo sapiens
• Sequence 2: NP_651315.2
• Gene: Nmnat / 42987
• FlyBaseID: FBgn0039254
• Length: 389
• Species: Drosophila melanogaster
• Alignment Length: 257
• Identity: 116/257 - (45%)
• Similarity: 160/257 - (62%)
• Gaps: 21/257 - (8%)

Human     9 VVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGLIPAYHRVIMAELA 73
            :..:|||.|:|.|.||||:||:|||:....|.:.||.|||||..|:|.||||..|..|..|.:||
  Fly    46 IAFIACGCFSPPTPMHLRMFEIAKDHFEMQGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLA 110

Human    74 TKNSKWVEVDTWESLQKEWKETLKVLRHHQEKLE------ASDCDHQQNSPTLERPGRKRKWTET 132
            |::|.|:.:..||..|.:|..|..||:|||..:.      ....|..:|:   ..||    |.
  Fly   111 TQSSNWIRLSDWEVHQNQWMRTQAVLQHHQNYINNHINSGGGGGDDGENT---HLPG----WL-- 166

Human   133 QDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQKFI 197
                 .:.|......| .:|||||||||||||||.||...||..||||:||:.:||||::..|||
  Fly   167 -----PRGLHDSRDPV-HLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFI 225

Human   198 YESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHNLYSSESE 259
            ::||:|.|::|||.::..|:.|::|||.|||.|.||||::||:.|||.|||::..|::.:|:
  Fly   226 FDSDILTKYQSNITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNFKSK 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NMNAT1	NP_073624.2	NMNAT_Eukarya	9..254	CDD:185681	114/250 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	107..144		6/42 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	123..129		2/5 (40%)
Nmnat	NP_651315.2	NMNAT_Eukarya	46..282	CDD:185681	114/250 (46%)