Protein Alignment BMI1 and mig-32

DIOPT Version :10

• Sequence 1: NP_005171.4
• Gene: BMI1 / 648
• HGNCID: 1066
• Length: 326
• Species: Homo sapiens
• Sequence 2: NP_001255620.1
• Gene: mig-32 / 178150
• WormBaseID: WBGene00008684
• Length: 549
• Species: Caenorhabditis elegans
• Alignment Length: 248
• Identity: 67/248 - (27%)
• Similarity: 117/248 - (47%)
• Gaps: 34/248 - (13%)

Human     4 TTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLET-SKYCPICDVQVHKTRPLL 67
            |.:..:..|||.:.|.:|.||.:||||||:|:|:|||:|::.|.|: :..||.|...:|.:.|..
 Worm   315 TVKYNMEVLNPFITCGICDGYIVDATTIIDCMHTFCKSCLLTYFESDNNTCPTCGTFIHGSHPTH 379

Human    68 NIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVAD-EDKRIITDDEII 131
            .:..|:.:.::|.:.||.:..||:..|:.|......|...:.:.|||..... |.:||...:...
 Worm   380 YVTYDRAVNELVNQFVPKMENNELDVRKTFLRDCREALGIDTAAEDRERKERLERERITGTNRCY 444

Human   132 SLSIEFFDQNRLDRKVNKDKEKSKEEVN-----------DKRYLRCPAAMTVMHLRKFLRSKM-- 183
            .|....|..:|.|.:|.         ||           .:.|:||....|:..|:|||..::
 Worm   445 PLERPRFSHHRDDCQVT---------VNLLPGTANLPLITRPYVRCSEMTTMNTLKKFLSLQIWD 500

Human   184 DIPNTFQIDVMYEEEPL-KDYYTLMDIAYIYTWRRNG-----PLPLKYRVRPT 230
            |......:|:..:.:.: ||:    .:.:::..:|.|     ||.::|.:..|
 Worm   501 DQSRYSDLDMFCDGQLMGKDF----SVRFVWMMKRRGQPKSEPLIIRYHMTRT 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMI1	NP_005171.4	RING-HC_PCGF4	5..101	CDD:438394	34/96 (35%)
		Nuclear localization signal. /evidence=ECO:0000255	81..95		4/13 (31%)
		RAWUL_PCGF4	130..226	CDD:340685	23/114 (20%)
		Interaction with PHC2. /evidence=ECO:0000269|PubMed:27827373	162..182		8/19 (42%)
		Interaction with E4F1. /evidence=ECO:0000269|PubMed:16882984	164..228		16/71 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	236..326
mig-32	NP_001255620.1	RING-HC_PCGF3	316..382	CDD:438393	26/65 (40%)
		RAWUL_PCGF_like	459..545	CDD:340519	19/98 (19%)