Protein Alignment EPS8L2 and Eps8l2

DIOPT Version :10

• Sequence 1: NP_073609.2
• Gene: EPS8L2 / 64787
• HGNCID: 21296
• Length: 715
• Species: Homo sapiens
• Sequence 2: NP_573454.2
• Gene: Eps8l2 / 98845
• MGIID: 2138828
• Length: 729
• Species: Mus musculus
• Alignment Length: 718
• Identity: 615/718 - (85%)
• Similarity: 657/718 - (91%)
• Gaps: 8/718 - (1%)

Human     1 MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKS 65
            ||||.::||||||.||||||||||.:||.||||||||||||||||||||||||||||||||||||
Mouse     1 MSQSASMSCCPGAANGSLGRSDGVPRMSAKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKS 65

Human    66 EAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQL 130
            |||.|||||||||||||||||:|.||:||||||:||||||:|||||||:|||||||.||||||||
Mouse    66 EAIASVDDAIRKLVQLSSKEKVWAQEVLLQVNDKSLRLLDVESQEELENFPLPTVQHSQTVLNQL 130

Human   131 RYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQR 195
            |||||||||||||:|:|||:|||||||||||||.|||||||||.|||||||||||||||||||||
Mouse   131 RYPSVLLLVCQDSDQNKPDIHFFHCDEVEAELVQEDIESALADYRLGKKMRPQTLKGHQEKIRQR 195

Human   196 QSILPPPQGPAPIPFQHRGGDSPEAKNRVG-P-QVPLSEPGFRRRESQ-EEPRAVLAQKIEKETQ 257
            ||||||||.|||||||.:.||||:|||||| | .||.||||:|||||| |||||||||:||||||
Mouse   196 QSILPPPQSPAPIPFQRQPGDSPQAKNRVGLPLPVPFSEPGYRRRESQDEEPRAVLAQRIEKETQ 260

Human   258 ILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIK 322
            ||||.||||||||||||||||||||||||||||||.||.||||||||||||||||||:|||||.|
Mouse   261 ILNCTLDDIEWFVARLQKAAEAFKQLNQRKKGKKKNKKGPAEGVLTLRARPPSEGEFVDCFQKTK 325

Human   323 LAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPK 387
            ||||||||||||||||||||||||||||||||:|||..||||||||.||||.|||.|||||||||
Mouse   326 LAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCGSPDIARSVSSPLLSTDAVSFLRGHLVPK 390

Human   388 EMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVS 452
            ||:|||||||:|||||||||||||||||||||.||||||:|||||||||||||||.|.::::|.:
Mouse   391 EMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEVEGLASVPSDQLTPKN 455

Human   453 RQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDE 517
            |.|:|:|.|||.:||...|.|..||.||||.:|||||||||.|||||||||||||||||||||||
Mouse   456 RLSVRHSPKHSLSSESQAPEDIAPPGSSPHANRGYQPTPAMTKYVKILYDFTARNANELSVLKDE 520

Human   518 VLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGN 582
            |||||||||||||||:|||||||||||||.|||.||.|||.||:||||||||||||||||.|.||
Mouse   521 VLEVLEDGRQWWKLRNRSGQAGYVPCNILAEARQEDVGAPLEQSGQKYWGPASPTHKLPPIFAGN 585

Human   583 KDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIV 647
            |:||:.|||||||||::|||:|:.||||:|||||||||..|||:|||||||||||||||||.|||
Mouse   586 KEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQPVHLPLTFESGPDEVRAWLEAKAFSARIV 650

Human   648 ENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRG 712
            |||||||||||||||||||||||||||.|||||||:|||||||||||||||:||:|.     ||.
Mouse   651 ENLGILTGPQLFSLNKEELKKVCGEEGSRVYSQLTVQKAFLEKQQSGSELEKLMSKI-----RRA 710

Human   713 EDS 715
            |||
Mouse   711 EDS 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS8L2	NP_073609.2	PTB_EPS8	48..178	CDD:269921	116/129 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..243		51/62 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..487		19/38 (50%)
		SH3_Eps8	496..546	CDD:212698	48/49 (98%)
		SAM_EPS8-like	623..688	CDD:188939	60/64 (94%)
Eps8l2	NP_573454.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		19/23 (83%)
		PTB_EPS8	48..178	CDD:269921	116/129 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..247		53/64 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..492		21/42 (50%)
		SH3_Eps8	499..549	CDD:212698	48/49 (98%)
		SAM_EPS8-like	626..691	CDD:188939	60/64 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	695..729		15/24 (63%)