Protein Alignment EPS8L2 and CG8907

DIOPT Version :10

• Sequence 1: NP_073609.2
• Gene: EPS8L2 / 64787
• HGNCID: 21296
• Length: 715
• Species: Homo sapiens
• Sequence 2: NP_001247146.1
• Gene: CG8907 / 42050
• FlyBaseID: FBgn0038466
• Length: 732
• Species: Drosophila melanogaster
• Alignment Length: 786
• Identity: 208/786 - (26%)
• Similarity: 324/786 - (41%)
• Gaps: 185/786 - (23%)

Human     1 MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKS 65
            |.|:|..:..||. |.:.|..|.|                        ...|.::|||||.:...
  Fly    21 MPQNGYENGVPGG-NQANGHYDEV------------------------KPTYALEHLATFKLKNE 60

Human    66 EAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLN-- 128
            ..:....:.::.||:|.....||..:|.:..|.|.|.:|| ...:|:|:||...:......::
  Fly    61 AEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLD-SDMKEIENFPGSLITEPTAFISDH 124

Human   129 -QLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKI 192
             |..:.::|:...........::|.|...:|.:.|:.||:::.       .|..|.|:..::..|
  Fly   125 PQESFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL-------SKGTPVTVDRNKTPI 182

Human   193 RQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQ 257
                 :||.|:.|          .:.:||::.|  :..:..|.     ..|..|:..::.|::.|
  Fly   183 -----LLPKPERP----------QNQQAKDQYG--IAAAVAGI-----AAEKNAIDKEQTERDVQ 225

Human   258 ILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAP-AEGVLTLRARPPSEGEFIDCFQKI 321
            ::|...:|||.|:|||..||||..:|..||:     :..| .||:|.||:|||.|.||.|...|.
  Fly   226 VINHCFEDIERFMARLHYAAEALNELKLRKE-----QHNPHGEGLLVLRSRPPIESEFHDILAKA 285

Human   322 KLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCS----GPDIARSVSCPLLSRDAVDFLRG 382
            |||:....:||.....|  |:.||.:|..|..||..|:    ...:.::|..|||.|:.:.||.|
  Fly   286 KLALIYSVRLQNQFTKP--ADPVHNVFISLKSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNG 348

Human   383 HLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEE 447
            .|...||.||:|||.:|..|:.::  :.....|.|.|:..|.|        .|.|:       ||
  Fly   349 TLDSNEMQLWQSLGPNWTVPKDQF--KDHKSSYHPIFYDDWSP--------DWVVD-------EE 396

Human   448 VSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGY--QPTPAMAKYVKILYDFTARNANE 510
            | |....:::.|...||...|.||...|       .:|.:  :......|..::.::.:|.|..|
  Fly   397 V-PYLAPALKKSTTPSPVPVPMPPSPGL-------GNRTWLSRLESRNVKIAEVTFNKSATNDKE 453

Human   511 LSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNIL------------------GEARPEDAG-- 555
            |.|.|.|.||:::|.|.|||.|:..|..||||..:|                  ..|..|:.|
  Fly   454 LKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNFEPGVNGRDTESLASMALTENGGEE 518

Human   556 ---------------APFEQ------AGQKYWGPASPTHKLPPSFPGNK---------------- 583
                           ||.||      |.|:.:  :.|...:||..|...
  Fly   519 AIPPPLYRNTMAMYTAPVEQPAANGKAMQRTF--SMPNVPVPPPMPPPSDSQTPTPSGTLKRNMA 581

Human   584 -----------------DELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQP---LTYES 628
                             |:|.....:|:|||       |...|:..|.:..:.:..|   :|..|
  Fly   582 AAGALAAMRARNDCEADDQLYYMQGDVHDEL-------RLLQQQRERRKDLEILKTPEIFITQNS 639

Human   629 GPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCG-EEGVRVYSQLTMQKAFLE-KQ 691
            .|.||..||..|.||..|::.|..|:|.::|:|:...::...| .|..|:.||:.:||.|.| |.
  Fly   640 KPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFGRRESRRLISQIVLQKNFCEYKT 704

Human   692 QSGSEL 697
            ...|||
  Fly   705 IRSSEL 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS8L2	NP_073609.2	PTB_EPS8	48..178	CDD:269921	29/132 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..243		10/59 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..487		10/38 (26%)
		SH3_Eps8	496..546	CDD:212698	20/49 (41%)
		SAM_EPS8-like	623..688	CDD:188939	24/68 (35%)
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	32/163 (20%)
		SH3_Eps8	439..492	CDD:212698	21/52 (40%)
		SAM_3	630..693	CDD:436214	21/62 (34%)