Protein Alignment EPS8L2 and Eps8l2

DIOPT Version :10

• Sequence 1: NP_073609.2
• Gene: EPS8L2 / 64787
• HGNCID: 21296
• Length: 715
• Species: Homo sapiens
• Sequence 2: NP_001386596.1
• Gene: Eps8l2 / 361674
• RGDID: 1310912
• Length: 729
• Species: Rattus norvegicus
• Alignment Length: 718
• Identity: 608/718 - (84%)
• Similarity: 655/718 - (91%)
• Gaps: 8/718 - (1%)

Human     1 MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKS 65
            ||||..:||||||.||||||||||.:||.||||||||||||||||||||||||||||||||||||
  Rat     1 MSQSANMSCCPGAANGSLGRSDGVPRMSAKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKS 65

Human    66 EAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQL 130
            |||.:||||||||||||||||:|.||:||||||:||||||:|||||||:|||||||.||||||||
  Rat    66 EAIATVDDAIRKLVQLSSKEKVWAQEVLLQVNDKSLRLLDVESQEELENFPLPTVQHSQTVLNQL 130

Human   131 RYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQR 195
            |||||||||||||:|:|||:||||||||||:||.|||||||||.|||||||||||||||||||||
  Rat   131 RYPSVLLLVCQDSDQNKPDIHFFHCDEVEADLVQEDIESALADYRLGKKMRPQTLKGHQEKIRQR 195

Human   196 QSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVP--LSEPGFRRRESQ-EEPRAVLAQKIEKETQ 257
            ||||||||.|||||||.:.||||:||||||..:|  .||||:|||||| |||||||||:||||||
  Rat   196 QSILPPPQSPAPIPFQRQPGDSPQAKNRVGLPLPASFSEPGYRRRESQDEEPRAVLAQRIEKETQ 260

Human   258 ILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIK 322
            ||||.||||||||||||||||||||||||||||||.||.|||||||||||||:||||:|||||.|
  Rat   261 ILNCTLDDIEWFVARLQKAAEAFKQLNQRKKGKKKNKKGPAEGVLTLRARPPTEGEFVDCFQKTK 325

Human   323 LAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPK 387
            ||||||||||||||||||||||||||||||||:|||.|||:|||||.||||.|||.|||||||||
  Rat   326 LAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCGGPDLARSVSSPLLSTDAVSFLRGHLVPK 390

Human   388 EMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVS 452
            ||:|||||||:|||||||||||||||||||||.||||||:|||||||||:|||.|.|.::::|.|
  Rat   391 EMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEIEGLTSVPSDQLNPKS 455

Human   453 RQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDE 517
            |.|:|:|.|||.:|||..|.|..||.||||.:|||.|||||.|||||||||||||||||||||||
  Rat   456 RLSVRHSPKHSLSSEPQVPEDVAPPGSSPHANRGYHPTPAMTKYVKILYDFTARNANELSVLKDE 520

Human   518 VLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGN 582
            |||||||||||||||:|||||||||||||.|||.||.|||.||:||||||||||||||||.|.||
  Rat   521 VLEVLEDGRQWWKLRNRSGQAGYVPCNILAEARQEDVGAPLEQSGQKYWGPASPTHKLPPIFAGN 585

Human   583 KDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIV 647
            |:||:.|||||||||::|||:|:.||||:|||||||||..|||:||||:||||||||||||.|||
  Rat   586 KEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQPVHLPLTFESGPEEVRAWLEAKAFSGRIV 650

Human   648 ENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRG 712
            |||||||||||||||||||||||||||.|||||||:||:||||||||||||:||||.     ||.
  Rat   651 ENLGILTGPQLFSLNKEELKKVCGEEGSRVYSQLTVQKSFLEKQQSGSELEKLMNKI-----RRA 710

Human   713 EDS 715
            |||
  Rat   711 EDS 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS8L2	NP_073609.2	PTB_EPS8	48..178	CDD:269921	114/129 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..243		49/62 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..487		21/38 (55%)
		SH3_Eps8	496..546	CDD:212698	48/49 (98%)
		SAM_EPS8-like	623..688	CDD:188939	58/64 (91%)
Eps8l2	NP_001386596.1	PTB_EPS8	48..178	CDD:269921	114/129 (88%)
		SH3_Eps8	499..549	CDD:212698	48/49 (98%)
		SAM_EPS8-like	626..691	CDD:188939	58/64 (91%)