Protein Alignment EPS8L2 and eps-8

DIOPT Version :10

• Sequence 1: NP_073609.2
• Gene: EPS8L2 / 64787
• HGNCID: 21296
• Length: 715
• Species: Homo sapiens
• Sequence 2: NP_001360610.1
• Gene: eps-8 / 178411
• WormBaseID: WBGene00001330
• Length: 943
• Species: Caenorhabditis elegans
• Alignment Length: 912
• Identity: 241/912 - (26%)
• Similarity: 367/912 - (40%)
• Gaps: 286/912 - (31%)

Human    20 RSD---GVAKMSPK-DLFEQRKKYSNSNVIMHE----TSQYHVQHLATFIMDKSEAITSVDDAIR 76
            |||   |..:|:|: |.......|.|...:...    |..|:|:|||||.:.:...:|...|.||
 Worm    64 RSDYRTGSEQMTPRSDHRGPSMGYGNGGSVDQRVDDVTPSYYVEHLATFAVGRQFGLTFPADGIR 128

Human    77 KLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTV-QRSQTVLNQLR--YPSVLLL 138
            ||.|:.....||.|.::|:....::.:.| ::.|.:|.|||..: |.:..|.|..|  |.:|||.
 Worm   129 KLKQMEKNSAIWAQPLILRFRHNAVTVED-DNGELVEQFPLELIEQPTAHVSNDSRETYNNVLLF 192

Human   139 VCQDSEQ--SKP-DVHFFHCDEVEAELVHED----IESALADCRLGKKMRPQTLKGHQEKIRQRQ 196
            |.::..:  |.| ::|.|.|..|.|..|.||    ::......|.|::....|   |.:..:|:.
 Worm   193 VVREDRKRMSTPTEMHIFQCIRVSATDVAEDLKNYVQGQFRRVRNGRRTAAPT---HLQAQQQQM 254

Human   197 SILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNC 261
            ...||.....                                 |.|     .::..|::...||.
 Worm   255 PFYPPDDASI---------------------------------SSE-----TSEMFERDVNTLNR 281

Human   262 ALDDIEWFVARLQKAAEAFKQLNQR--------KKGKKKGKKAPAEGVLTLRARPPSEGEFIDCF 318
            ..||||.||||:|.||.|.:::.|:        ::.||..:.....|:|.:||:.|.|.||:|..
 Worm   282 CFDDIERFVARIQSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDIL 346

Human   319 QKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCS---GPDIARSVSCPLLSRDAVDFL 380
            :|.||:.||||||:.||..|:|.||:||||.||.:|:..|.   |.::|.:|:.||||.:|.:.:
 Worm   347 KKFKLSFNLLAKLKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPTVASPLLSLEARELM 411

Human   381 RGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEP--PVDVLQEAPWEVEGLASA 443
            :..|...|..:|.||||:|..|..:|.: |..|.|.|.|:.|:.|  ..|.....|.::....||
 Worm   412 QNCLTSHESDIWMSLGEAWRTPPEDWTK-PLPPPYRPIFNDGFAPYGVADRAMATPNQIHRGHSA 475

Human   444 PIE-------------EVSPVSRQSIRNSQKHSP------------------------------- 464
            |.|             :.:|.:.||::.:.|..|
 Worm   476 PPEHFRQPPPRERNMVDTAPNTPQSMQRTPKSRPPHRNMSVDNLEFDRLTLERERLEFEKAKIME 540

Human   465 -----------------------------TSEPTPPGDAL-----------PPVS-SPHTHRG-- 486
                                         |::|.||..|:           ||:| ||...|.
 Worm   541 RESRLRHEEKQIEDEKRRMHAEKDLITKETTQPVPPPAAVVTHQPITKRYDPPISISPPPQRNNY 605

Human   487 --------YQPTPAMAKYVK-----------ILYDFTARNANELSVLKDEVLEVLEDGRQWWKLR 532
                    ...:|....::.           :.||...:|..||:|.|.|.|||:.|.|.||:.:
 Worm   606 SHVKVTVDSDTSPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFDERNWWECK 670

Human   533 SRSGQAGYVPCNILGEARPEDAGAPFEQAGQKY--------------------WGPASPTHKLPP 577
            :...:.||||..||       :..||||  |:|                    .|||...::.||
 Worm   671 NMHQRVGYVPHTIL-------SMVPFEQ--QQYASPNHHNNSSSTGGYNNGHHQGPAQNVYRPPP 726

Human   578 ----SFPGNKDEL-MQHM-----------------DEVNDELIRKISNIRAQPQRHFRVERSQPV 620
                |..|.:.|: .:|:                 ....:||:| :...:.|.||...||  :||
 Worm   727 PPLVSDAGVQVEIRREHVAPPPPPVVIPPPPPPVRTPTMEELLR-MQQQQQQKQRKPPVE--EPV 788

Human   621 SQP----------------------------------------------LTYESGPDEVRAWLEA 639
            .||                                              :..:|.|::|..||:.
 Worm   789 YQPQPAQRAGLEIWRRNQNPQLIQEVTETVGQHSGDILRPAMQRATRVAINEKSSPEDVTRWLQE 853

Human   640 KAFSPRIVENLGILTGPQLFSLNKEELKKVCG-EEGVRVYSQLTMQK---AFLEKQQSGSELEEL 700
            |.||||:::.|....|..||||:|..|::.|| :||..:||||.:||   .|  :..:|.||:.:
 Worm   854 KGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGF--RTHTGDELKAI 916

Human   701 MN 702
            :|
 Worm   917 LN 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS8L2	NP_073609.2	PTB_EPS8	48..178	CDD:269921	45/143 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..243		6/59 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..487		16/120 (13%)
		SH3_Eps8	496..546	CDD:212698	19/60 (32%)
		SAM_EPS8-like	623..688	CDD:188939	29/114 (25%)
eps-8	NP_001360610.1	PTB_EPS8	100..231	CDD:269921	44/131 (34%)
		CAF-1_p150	<528..575	CDD:402959	2/46 (4%)
		SH3_Eps8	634..687	CDD:212698	21/59 (36%)
		SAM_3	836..897	CDD:436214	25/60 (42%)