Protein Alignment CRTC3 and Crtc

DIOPT Version :10

• Sequence 1: NP_073606.3
• Gene: CRTC3 / 64784
• HGNCID: 26148
• Length: 619
• Species: Homo sapiens
• Sequence 2: NP_001261997.1
• Gene: Crtc / 39970
• FlyBaseID: FBgn0036746
• Length: 889
• Species: Drosophila melanogaster
• Alignment Length: 894
• Identity: 184/894 - (20%)
• Similarity: 266/894 - (29%)
• Gaps: 386/894 - (43%)

Human    10 ANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQL----- 69
            ||||||||||||..|:|||.|..||::|.::..::.......|..|....||.  .|||.
  Fly     2 ANPRKFSEKIALQKQKQAEGTAEFERIMKEVYATKRDEPPANQKILDGLVGGQ--EVSQSSPGAG 64

Human    70 -------RSSASEFQPSFHQADNVRGTRHHGLVERPSRNR---FHPLHRRSGDKPGRQFDGSAFG 124
                   ..|.|.........|.:.|........|.||.|   ..|:.|.|    .|:.|.|.:|
  Fly    65 NGTGGGGSGSGSGASGGGASPDGLGGGGGSPTAYRESRGRSVGVGPMRRPS----ERKQDRSPYG 125

Human   125 ANYSSQPLDESW--------PRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSAL---------- 171
            ::.:.|.||...        |..:..|:              |::||||||.|||
  Fly   126 SSSTQQTLDNGQLNPHLLGPPTAESLWR--------------RSSSDSALHQSALVAGFNSDVNS 176

Human   172 ---------STKPQDPYGGGGQSAWPAPYMGF--------------------------------C 195
                     ..:.|.|    ||....:|:.|.                                .
  Fly   177 MGANYQQQQHQQQQQP----GQPRSHSPHHGINRTMSPQAQRRKSPLLQPHQLQLQQLQQQQQQM 237

Human   196 DGENNGHGEV-------------------------ASFPGPL-----KEENLLNV---------- 220
            ..::..|.::                         |.|..|:     .:.|..|.
  Fly   238 QHQHQLHQQLQMQQLQQHQQQHQQQQQQQNTPYNNAKFTNPVFRPLQDQVNFANTGSLPDLTALQ 302

Human   221 --------------PKPLPKQLWET----------KEIQSLSGRPRSCDVGGGNAFP-------- 253
                          |....:||.:|          :..:..|..|.|...|||.|.|
  Fly   303 NYGPQQQQQQSQQQPSQQQQQLQQTLSPVMSPHNHRRERDQSPSPFSPAGGGGGAGPGSPYQQQQ 367

Human   254 -----------HNGQNLGLSPFLGTLN---------TGGSLPDL--------------------- 277
                       ...|....||.|...|         |...||.|
  Fly   368 HSPTGNTQQQQQQHQQPSNSPHLSFTNLATTQAAVTTFNPLPTLGPHNATDYRQPPNPPSPRSSP 432

Human   278 --------TNLHYSTPLPA-----------------------------SLDTTDHH-FGSMSVGN 304
                    |:||.|.|...                             ||:|:.|: |...|:|:
  Fly   433 GLLSSVSATDLHSSAPASPIRQQQQAHQQQQQQQQAQQQQQQFDNSYNSLNTSFHNQFEIFSLGD 497

Human   305 S---------VNNIPA------------AMTHLGIRSSSGLQSSRSNPSIQ--ATLNKTVLSSSL 346
            |         .||..|            ..:..|..:..||.:..:.|.:.  :.|:.:..:|..
  Fly   498 SNSSPEQQGFANNFVALDFDDLSGGGGGGPSGGGGSNGGGLTNGYNKPEMLDFSELSGSPEASGN 562

Human   347 NNHPQTSVPNASALHPSLRLFSLSNPSLS----------TTNLSGPSRRR--------QPPVSPL 393
            |||.:..|.|            |:|..||          :|||:|.....        |.|:. :
  Fly   563 NNHMRRGVSN------------LNNNGLSNGVVGSTHNGSTNLNGAGNNNSSSGGGTAQDPLG-I 614

Human   394 TLSPGPEAHQGFSRQLSSTSPL----APYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQEL 454
            |.||.|             |||    :|.|              :|....||.||...:...|:.
  Fly   615 TTSPVP-------------SPLGCPSSPLP--------------IPIPMSAQSSPQQQHHHHQQQ 652

Human   455 TQPLLQQPRAPEAPAQQPQAASSL---PQSDFQLLPAQGSS-LTNFFP---------DVGFDQQS 506
            .|...||..     .||.|.:.||   |.......|..|:| |::..|         :|..:.|
  Fly   653 QQQHHQQQH-----HQQQQLSLSLHHSPHHSPMHSPHHGNSPLSSSSPVSHNACSNSNVVMNHQ- 711

Human   507 MRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSNCGSLPNTILPEDSSTSLFKDLNSALAGLPEV 571
                          ||..:......|.:.|..|:..:..|  :|    :.:|.|.:|
  Fly   712 --------------QQQQQHHHQQHHHQGSSQSHTPTTAN--IP----SIIFSDYSS-------- 748

Human   572 SLNVDTPFPLEEELQIEPLSLD--GLNMLSDSS-MGLLDPSVEETFRAD 617
              |.|....:.:.|.::...:|  ||.||||.: :.:.||::|::||.|
  Fly   749 --NADYTREIFDSLDLDLGQMDVAGLQMLSDQNPIMIADPNIEDSFRRD 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRTC3	NP_073606.3	Required for interaction with HTLV-1 TAX	1..103		35/107 (33%)
		TORC_N	11..64	CDD:463738	23/52 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..150		12/54 (22%)
		TORC_M	159..319	CDD:463739	60/382 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..185		9/38 (24%)
		PHA03378	<346..537	CDD:223065	49/225 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..431		16/77 (21%)
		Required for interaction with PPP2CA and PPP2R1A. /evidence=ECO:0000250|UniProtKB:Q91X84	380..401		7/28 (25%)
		TORC_C	545..619	CDD:463740	21/76 (28%)
Crtc	NP_001261997.1	TORC_N	3..61	CDD:463738	26/59 (44%)
		TORC_C	<761..795	CDD:463740	12/33 (36%)